downwardsfromzero
Boundary condition
Noticed this, found it interesting:
Study Finds Aeruginascin Metabolite 4-HO-TMT is Active at the Serotonin 5-HT2A Receptor
Surprisingly, 4-HO-TMT has binding affinity similar to psilocin at 5-HT2A.
psychedelicreview.com
Compound 5-HT1A 5-HT2A 5-HT2B 5-HT3
4-HO-TMT 4,400 670.0 120.0 >10,000
4-AcO-TMT >10,000 >10,000 >10,000 >10,000
Psilocin 567.4 107.2 4.6 >10,000
Psilocybin >10,000 >10,000 98.7 >10,000
4-AcO-TMT showed no binding activity at any of the receptors tested. However, 4-HO-TMT had activity at 5-HT1A, 5-HT2A, and 5-HT2B. Agonist activity at 5-HT2A is regarded by experts as the hallmark of psychedelic activity.16
Although 4-HO-TMT showed less binding affinity at 5-HT2A than psilocin, the authors concluded that the Ki values were comparable (670.0 nM and 107.2 nM, respectively). Also, the data showed that 4-HO-TMT has a similar affinity for 5-HT2B compared to psilocybin.
Recall that one of the hypotheses Chadeayne et al. was testing was that aeruginascin’s active metabolite 4-HO-TMT would have an affinity for 5-HT3 like bufotenine. The data showed this was not the case. The Ki for 4-HO-TMT at 5-HT3 was >10,000 nM.
[...]
Despite the value gained from these tests, it is unclear why Chadeayne et al. did not test the two compounds at nicotinic acetylcholine receptors. The results may have shed some light on the possible role of aeruginascin (or its metabolite) in the phenomenon known as wood lover paralysis.