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Syrian rue: antidepressant, no nausea, & a question about DMT

ErosIsOne

Rising Star
Hey all, OneIsEros here returning as ErosIsOne. One Love. Had trouble recovering my old account.

So, I’ve been taking syrian rue every day as an antidepressant, grinding 3.5 grams into a powder, putting it in toilet paper, and swallowing it. I have learned something not widely known in this community, because of how we all generally do syrian rue with DMT….

Syrian rue, taken as a powder orally, does not cause nausea until you take DMT with it. I have given this dose of dry syrian rue powder to several others and they have all agreed: it does not cause nausea…. Until you eat DMT. Then, it is nauseating.

Also: syrian rue is a powerful antidepressant. And also: there is a kind of tolerance buildup to it. Not overly strong, but contrary to what people say, it is not entirely without tolerance: I have noticed qualitative change in the course of taking it, where at first it was almost euphoric for the first several days, and then it settled into a still very active but less dramatic antidepressant where mood levelled out to normal. There isn’t much tolerance though, it seems to remain basically fully effective with daily use.

Just wanted to share all that. Now, a question for you all: what, in your experience, is the least nauseating form of DMT in pharmahuasca? In vinegar? Orange juice? Lemon juice? Cola? Taken as a raw dry freebase? As a fumarate? And how would you rank them?
 
Yeah i've been dosing Rue/Harmalas on the regular (daily/near daily, mostly daily) for 12 years and counting, it works really well as an anti-depressant and medicine.

With the nausea/vomiting, i've noticed this too for sure, however, ime i've also noticed that Rue/Harmalas on their own seem fine on their own for the most part, but when DMT is added the DMT seems to bring out the effects of the Harmalas more, including the Harmalas' purgative properties. So it's not so much that the DMT itself is causing the nausea/vomiting, but that it's bringing out the effects of the Harmalas and triggering the Harmala purge. If you consume the Harmalas/Rue in good dosages for a few weeks or so, over time the Harmala-related side-effects including it's purgative effects will go away completely, which cleans up the side-effect profile and bodyload of the Harmalas/Rue while maintaining the beneficial properties/effects.

Harmalas/Rue/Caapi definitely causes nausea/vomiting on their own, if taken in a high enough dosage, or if a good dosage is taken nightly and you build up the Harmala reverse tolerance which makes the Harmalas' effects stronger and stronger each night, then the higher dosage Harmala-related side-effects will start to come out more, even without DMT in the mix. But like i said, over time with regular Harmala consumption, even though the reverse tolerance builds up and the Harmala content/effects get stronger and stronger and you can enter into heavy Harmala territory and thus get the Harmala-related side-effects, over time the side-effects will go away as the related properties of the Harmalas get desensitized, and thus the Harmala-related nausea/vomiting (and bodyload) will go away while maintaining the beneficial effects of the Harmalas.

As far as DMT itself goes, you might refer to my post i just made here - DMT + Nausea? - But basically DMT has Adrenergic properties which is why it's so intense, and from what i've read Adrenergic stimulation or if someone goes into fight or flight mode, some people reportedly experience nausea/vomiting from Adrenaline/Adrenergic receptor stimulation (primarily Adrenergic Alpha 1 (likely 1A) stimulation), especially on top of MAO-A inhibition or whatever else the Harmalas may be doing. And so once you take care of and knock out the Harmala-related nausea/vomiting, DMT shouldn't be an issue as far as nausea/vomiting goes, but if it does still cause nausea/vomiting, ime if you consume the DMT regularly as well, you also become accustomed to the DMT and so once the body gets used to it's Adrenergic properties and maybe something gets desensitized, then that nausea/vomiting aspect of the DMT will go away as well, and thus both the Harmalas and the DMT will be cleaner, more functional, and with little to no side-effects, ime, especially compared to how things are at the very beginning (especially on the Harmala side lol).

With that said, one thing i did a few good times a few years ago was to use 10 drops of pure Limonene in a capsule taken at the same time as the Harmalas/Rue, to block out the Harmala-related nausea/vomiting, and so i'd take the Limonene with the Harmalas/Rue for a good few weeks and let the Harmala reverse tolerance build up, and the Limonene blocked out the Harmala-related nausea/vomiting while the Harmala reverse tolerance built up and the properties causing the side-effects got desensitized, at which point i stopped taking Limonene and from then on the Harmalas/Rue was side-effect free and no nausea/vomiting. It also seems to clean up DMT's bodyload as well, and so technically once could have DMT in the mix from the get go and Limonene should help either way, ime. Limonene as far as i know does not antagonize the Serotonin 3 receptor, like Zofran, Ginger and Menthol/Peppermint do, instead it acts as a Serotonin 1A agonist which can in turn inhibit the NK1 receptor which can then cause anti-emetic properties, but Limonene also is an Adenosine A2A agonist which i'm not sure if it contributes to the anti-emetic properties or other benefits or not, but Adenosine A2A agonism can reduce Dopamine 2 activity, and has some properties which seems to increase gastrointestinal peristalsis, but i'm willing to bet it's moreso the Serotonin 1A agonism and NK1 inhibition that blocks out the nausea/vomiting from Harmalas/DMT because apparently NK1 is iirc the central receptor that other neurotransmitter systems like Serotonin, Dopamine, Acetylcholine, Opioid, etc all activate in the CTZ (chemoreceptor trigger zone), and so inhibiting NK1 apparently prevents all neurotransmitter systems from sending their signals to activate NK1 which would then trigger nausea/vomiting, so by inhibiting NK1, you block out the nausea/vomiting.

But yeah as far as tolerance goes, there really is no actual tolerance to Harmalas as far as it's main properties go, there is some tolerance to other properties though which get desensitized which is why the Harmalas clean up, but in general there's no tolerance to it's main properties so it really has no tolerance, just some properties do. DMT is the same way, no tolerance, but you can get the body more used to it and it'll clean up a bit and make it more functionable/usable. But as far as the active effects of this stuff goes, i haven't had any actual tolerance, and if anything you do tend to get a bit more sensitive to things in the long run. This is imo why Aya is the king Psychedelic, because it has no tolerance, it's the more versatile Psychedelic compound and could be dosed nightly for years and years if one wanted to, i mean i took it daily/near daily for 4 years straight, i wouldn't have wanted it any other way lol.

As for the least nauseating form of DMT, i've only ever used the DMT-containing plants/plant teas, haven't yet used pure DMT orally, but as far as plant teas and reducing nausea/vomiting goes, i like to brew up a bulk batch of Mimosa or Acacia using like 100 grams of shredded root bark, i do multiple large boils like about 8 big boils and then combine then and reduce them down to like a liter or so, then i'll freeze/thaw/filter the teas a good few times to get a lot of the plant gunk and tannins out, and then on the last freeze/thaw i'll just suck up the clean tea away from any tea at the bottom that has any remaining tannins or what not, and then once i have the clean tea separated i'll reduce it down on the stove to final concentration of usually about 400 to 500mls total, it's a nice clean tea, free of tannins and plant gunk, very palatable/drinkable. I also like/prefer to sip on my DMT-containing teas for 10 to 15 minutes for a smoother come up, which may also reduce chances of nausea/vomiting btw since the DMT doesn't hit all at once and is a little more stretched out. But as far as pure DMT goes, i can't really speak on the differences, if any, between the different salt forms of DMT, but i would say probably DMT Fumarate in a capsule would likely be less nauseating compared to freebased DMT in a capsule, i've always read freebased DMT may cause some stomach upset and so DMT in a salt form is preferred, but DMT Fumarate is probably your best bet, but i'm not sure how it'd compare to say DMT Citrate, or DMT Phosphate, etc. But i just recommend sticking to plant teas if you can clean up well enough, but other than that i'd say DMT Fumarate maybe, perhaps dissolved into some water, perhaps with some sort of flavoring added to make it taste good, idk, but i like DMT in tea form because i can sip it, if i had to deal with it in pure capsule form it'd kick in all at once and be hella intense, i prefer to sip it for 10 to 15 minutes for a smoother come up, so i recommend tea lol.
 
I can also confirm from regular rue dosing that I've only had nausea on adding DMT (apart from early, high rue doses many moons ago without tolerance where the rue alone was mildly nauseating).

@Sabnock1990 - how are the plant brews after freezing the tannin out? Are they still astringent? A highly effective tannin removal method appears to be by cooking the bark in vodka at 60°C for 20 minutes, filtering, then adding the minimum necessary quantity of lime (Ca(OH)₂) slurry to precipitate calcium tannate. Filtering this makes a golden coloured, de-tanninised tincture which can be concentrated by freezing and separating the ice crystals. It may be necessary to lower the pH with a suitable acid afterwards, depending on one's goals and degree of care in having added the lime.
 
@Transform - For me, the Mimosa/Acacia brews after freezing is pretty clean, the freezing definitely seems to precipitate out most if not all of the tannins and plant gunk. The plant gunk can be easily filtered out, but those darn tannins are so minuscule that merge back into the water when filtering and slip right through the filters. If only tannins were big enough particles to actually filter out easily, that would be great lol.

But yeah i do a few full freezes, let em' completely thaw, all the plant gunk and tannins precipitate out and fall to the bottom, perhaps if left in the fridge for a bit all that gunk would settle and like clump together and one can just pour the tea off easily without disturbing the sediment, but i'm a bit impatient lol so i just freeze/thaw/filter em' a few times, each freezing seems to precipitate out more gunk, at some point i've noticed especially with Mimosa that a reddish oil will precipitate out and like stick to the bottom of the container, idk what the oil is, it's probably just some sort of plant oil/fats or something, but yeah freezing/thawing/filtering a couple or so more times past that point, leaves a very clean tea, but with some tannins at the bottom, hence why i use a syringe to suck up the clean up as much as possible away from the little bit of tea at the bottom with the residual tannins. The clean tea, once reduced/concentrated to final volume, is very drinkable/palatable, no tannins, no astringency, tastes pretty much like water, which i imagine perhaps one could add some flavoring to it or mix it with an herbal tea, i personally mix it with Lemon Balm tea and drink it while warm with some sweetness added, just tastes like an herbal tea, tastes clean, by far the way to go as far as water-based teas go imo.

Haven't found much else to get around the tannin issue, though i have read about using a higher pH to possibly precipitate out the tannins, perhaps then they might be a bit more filterable idk, the issue with that though is then re-acidifying it (and would there be any residual base in the tea after neutralization by the acid? i mean does it just go away or change into some inert chemical or does it linger in some form? plus, what about the acid itself, could it perhaps be neutralized after dissolving the DMT, and then just like with the base, what happens to the acid?), and personally i don't care for acidity if i can help it, ime it makes teas taste horrible and the smell worse, especially vinegar which smells like boiling vomit lol, i've also tried citric acid but the taste was just as horrendous and the smell also was a bit more increased while boiling, so i just don't use any acidity and just use straight water and shredded root, in a big pot, multiple boils, combine and reduce a bit, freeze/thaw/filter a good few times, and then use the syringe for the clean tea portion and reduce that down to final volume and it's good to go.

If it weren't for the taste and perhaps smell, i wouldn't mind trying out acidic brews a bit more to see if there's a difference, it would be interesting if there are differences depending on the salt form, but alas i just stick to regular ol' tea, and sometimes (and when i started out) some root powder capsules when i wanna go that route, but tea is best ime, and much preferred, but capsules are nice too, especially of like evaporated tea residues or some sort of alcoholic extract i imagine, which the method you describe sounds pretty much like what i described a moment ago, and i think that route could be interesting and doable imo, both using alcohol as well as just straight water perhaps, but the alcohol seems like a good way to go i think, which i assume pretty much any kind of alcohol should work though, right? I've wanted to make a nice concentrated tincture for awhile now, i just want something that'll taste fine and be palatable, like whether some drops in the mouth or dissolving it into like a tea. I'm also rather curious about an Aya nose spray lol, which i think it's probably doable and without a burn, just gotta make it so it doesn't irritate the nose, and then make sure it's concentrated enough and pure/clean enough to spray, i bet it'd be awesome lol.

But yeah as far as Aya nausea/vomiting goes, ime Harmalas/Rue (not so much Caapi because Harmine isn't really that much of a purgative, which i think is what brings in some confusion) has caused me hella nausea/vomiting, without DMT lol, just Harmalas/Rue on it's own, as the dosage increases, it's quite nauseating, though i don't think most people venture that deeply especially with Rue, not so much with the Rue dosage, 3 to 4 grams of Rue is plenty, 4 grams is STRONG lol and is plenty, don't need more than 4 grams.

But if taken nightly for a bit, the Harmala content gets stronger and stronger and stronger and it can become "a bit" too much lol, to say the least. Dizziness, motion sickness, tracers/trailing, a like light stuttering effect when moving around and moving the eyes, severe nausea/vomiting, i'm talkin' like purging the demons from the pits of your soul type vomiting, no DMT involved lol. I think the Harmala-related nausea/vomiting has more to do with the Acetylcholinesterase inhibition, but at the same time like different Acetylcholinesterase inhibitors ime affect me differently so some will feel lighter, some will feel heavier, some will feel more cerebral, some will feel much more physical, but ime there's some definite Cholinergic action going on with Harmalas, and with DMT (as well as Serotonin in general), and even Cannabis, and of course Tobacco, and all of that together you definitely notice the Cholinergic potentiation of things ime.

But if not the Acetylcholinesterase inhibition, Harmaline iirc does do something with Dopamine 2, and Dopamine 2 agonsim may cause nausea/vomiting, there's also some Opioid receptor activity that i think Harmaline is capable of as well and that of course can cause nausea/vomiting as well (and constipation, which ime i've gotten a lot of when dosing Rue over the years, though that could also perhaps be more reflective of my diet, or that i use ground up Rue seed encapsulated and that may potentially be a source of fiber idk, plus i have like microbiome issues, but i do notice more constipation when i dose Rue regularly vs when i don't).

But ime with Harmalas/Rue/Caapi/Harmine, i notice that when you take them on their own without DMT, the effect is rather cleaner, lighter, you don't notice certain aspects, and certain side-effects aren't there, unless you take higher dosages. But, when the DMT is then added, the effects of the Harmalas come out more than they do without the DMT in the mix, so the DMT (as well as other Psychedelics, like mushrooms, and 4-ACO-DMT) like illuminates and brings out the effects of the Harmalas, and that ime includes the Harmala purge.

Again though, DMT is very very Adrenergic, it's ime one of DMT's absolute main properties that i can feel/notice even from taking just one to 2 grams of Mimosa root powder encapsulated, it's the very first thing i feel/notice even when the DMT dosage isn't at the level where the Psychedelic effects start coming out, so like 1 to 2 grams of Mimosa powder to me feels a bit like a stimulant kinda, and i notice the same effect/feeling/property when smoking DMT too, it's what i associate with the intensity during the come up, if it weren't for the Adrenergic properties of DMT and if it felt more like Psilocin does when combined with Harmalas (a distinct lack of Adrenergic effects, very clean feeling, no nausea at all at least with 4-ACO-DMT, still can no doubt purge though) then the come up wouldn't be nearly as intense and would be less of an issue imo, hence why i prefer/recommend to sip on the DMT-containing tea for 10 to 15 minutes for a smoother/less intense come up, or to similarly sip on Changa by letting the initial come up feeling pass which only lasts a couple or so minutes and then once it stabilizes from there one can smoke on the Changa with ease and comfort and it's so much more inviting then and not jarring at all. So it just depends on how you prefer to work with/consume it, if you want it intense af (which has it's benefits) or if you want a smoother ride (which also has it's benefits).

But as far as it's Adrenergic properties and the nausea/vomiting goes though, i'm pretty sure that's where DMT's purgative effect comes from, it's also absent from Psilohuasca in that Psilocin lacks Adrenergic properties and at least i definitely notice the similarities and the differences due to receptor binding and such between Ayahuasca and Psilohuasca, for me Psilohuasca feels like and is Ayahuasca, just using Psilocin instead of DMT, and Psilocin isn't as complex in it's receptor binding profile from what i've seen and is rather more simple i think and that's definitely reflected back during the effects/experience. But DMT's Adrenergic properties i do believe is what causes the DMT purge, but like i said with regular consumption you do get used to that as well, and perhaps sipping on the DMT can also help with that by not having your system flood with Adrenaline but have more of a "slow drip" of Adrenergic effects.

Another thing is that Harmine is rather clean/clear in it's effects, compared to Harmaline. I've noticed that when i take Harmine itself, or when i take Caapi, it's not at all like Harmaline, Harmaline has a lot more going on than Harmine, but yet it is also capable of inducing the Harmala purge when dosed high enough or when allowing it to get stronger through the reverse tolerance. So when people take Caapi or Harmine, they're not going to really notice much in the way of purgative effects unless they dose high enough, but if you take a reasonable dose where there's not really any side-effects noticeable, and you add in the DMT, the DMT will bring out the effects of the Harmalas and can trigger the Harmala purge, but DMT's Adrenergic properties may contribute to that. With Rue/Harmaline though, it's a lot rougher at first until you get the body used to it, and so it's much more noticeable than Caapi or pure Harmine, and since Harmaline is the dominant and stronger Harmala in Rue, it's very easy to get into heavier territory with Rue/Harmaline than with Caapi/Harmine, and i think that helped me notice a lot more about what was going on with the Harmala side of things because Harmaline is much more active than Harmine, Harmine seems a bit more like Moclobemide in comparison, rather clean mentally and physically but with a definite Harmala feel/effect to it, Harmaline though is more active and thus more noticeable and so i've noticed things from it that also applies to Harmine but Harmaline brings things out more than Harmine does.

And so this effect of DMT bringing out the Harmala-related effects/side-effects that aren't particularly noticeable without the DMT in the mix, ime causes the DMT to trigger the Harmala purge, mainly, but secondarily, DMT's Adrenergic properties can also contribute i do believe, but once you get used to the Harmalas and the DMT, and let the side-effects go away, you can take it nightly and after awhile have purge-free experiences no matter the dosage, and much more functional and user-friendly and able to be better worked with then instead of just laying there and taking it lol, you can actually like get up and do things, but it's still best to spend the come up in a good space and focus inward and go through the process and then when things stabilize you can get up and move around, but no real side-effects at that point and the nausea/vomiting is a thing of the past, so long as you keep up with the tolerance/reverse tolerance.
 
Seriously though, i wouldn't mind some feedback from people who try Limonene with this stuff to see if it helps them with nausea/vomiting, it works like a charm for me, though Limonene can cause some diarrhea the first couple or so days if you're like backed up or what not i think, but that goes away, and the anti-emetic effect seems to be there from day one regardless. But ime it completely blocks out the nausea/vomiting from the Harmalas (no matter the dosage) and it blocks out whatever the DMT may do to trigger nausea/vomiting. Zofran, Ginger, Peppermint and some other things didn't really work for me, but Limonene did at 8 to 10 drops in a capsule. It also cleans up the bodyload, so like, if you take it with the Rue, the Rue will feel cleaner, i mean there'll still be some bodyload with the Rue, but Limonene definitely does something to clean it up.

Also Limonene has been shown to increase the expression/activity of Glutamate Decarboxylase (which requires adequate B6/P5P levels btw) to convert Glutamate into GABA, which then GABA can give some GABAergic effects like anti-anxiety and such but also does very similarly to what all the other GABAergics i've tried with Rue/Harmalas does, in that it cleans up the bodyload by counteracting Harmaline's GABA-A inverse agonism, and so that can clean up Rue's bodyload significantly, which is one reason i recommend Lemon Balm for cleaning up Rue's bodyload. It also can increase expression/activity of Tyrosine Hydoxylase as well btw, which can synthesize more L-Dopa from Tyrosine, which btw needs adequate levels of Folate (Methylfolate) and B12 for Tetrahydrobiopterin production which is needed in order for Tyrosine Hydroxylase (and other Hydoxylases) to synthesize the L-Dopa from the Tyrosine, and so definitely wanna make sure you're getting your B vitamins regardless of Limonene lol, but having the B vitamins with the Limonene (though ime Limonene and vitamins are best taken separately, i think) can really help produce more GABA and Dopamine at least ime.
 
Sabnock, what a wonderful and detailed response, I cannot thank you enough! I will absolutely look into limonene, thank-you so much!
 
Vodka happens to be the optimal strength of ethanol for effective tannin capture so, at first glance one could say it actually goes against our interests. However, some tannins do precipitate on cooling and standing after filtering the bark out, so a freeze pre-treatment would likely help economise on lime usage. (Thanks, @Sabnock1990, for helping with that tip.) The (MHRB) tannins seem to congeal with enough bulk that one can decant away from them fairly easily, and after the lime treatment the calcium tannate filters off cleanly (albeit slowly) through a cotton plug.

Calcium hydroxide has low (but nonzero) solubility in vodka, so it's worth doing a preliminary test to titrate the amount of lime needed. The tincture will probably be alkaline on account of DMT freebase but it seems possible to titrate against the tannins fairly exactly and thereby keep the pH lower. This may also result in yuremamine and possibly other pH-sensitive alkaloids surviving the process, which gives me the hunch that one ought to exercise a level of pharmacolgical caution if exploring this relatively unknown variant of extraction methods. (And I ought to put all this info in its own thread.) Maybe a pinch or two of lime would help coagulate the tannins even in an aqueous extraction and make filtering just a bit easier and more effective?


Nowadays I always put half a drop of lemon oil and half a teaspoon of good honey in my rue tea, admixtures or not. There's only so much wet dog taste one can tolerate! Seems I'd need a bit more than that for antinausea effects, but nausea hasn't been a problem for me and I can't entirely be bothered to fiddle around encapsulating stuff. There's also a part of me which would welcome a proper purge…
 
Rue always makes me feel like I have the flu the next day, along with next day diarrhea. It never bothers me physically during the experience without adding DMT. Does this change with prolonged exposure @Sabnock1990? It's always kept me away from going deeper with it. I hate peeing out of my butt and feeling like I got hit by a truck the next day.
 
Just wanted to update…. Two weeks in, yes, syrian rue is still in effect in many ways….. but the antidepressant effect is basically gone. In my personal experience of this plant, the antidepressant effect was very strong, at first, but it dwindled slowly, and now is gone.
 
Rue always makes me feel like I have the flu the next day, along with next day diarrhea. It never bothers me physically during the experience without adding DMT. Does this change with prolonged exposure @Sabnock1990? It's always kept me away from going deeper with it. I hate peeing out of my butt and feeling like I got hit by a truck the next day.
Yes, there can be some diarrhea at first, but ime the digestive disturbances go away once you get used to things, in fact it's more likely to cause me constipation than diarrhea but i do get the diarrhea at first and then with regular consumption you can literally eat right on top of Rue seed capsules and there's absolutely no stomach stuff ime, no nausea or vomiting or diarrhea, heck i just ate some chicken wangs an hour into my 2 gram Rue dose, currently in the second hour and no issues at all although i do have a few other things in the mix but you get the gist, with regular consumption Rue/Harmalas cleans up nicely, ime.
 
Just wanted to update…. Two weeks in, yes, syrian rue is still in effect in many ways….. but the antidepressant effect is basically gone. In my personal experience of this plant, the antidepressant effect was very strong, at first, but it dwindled slowly, and now is gone.
Try getting some Methylfolate, 15mgs, and some B12 (like 5mgs or so) because Methylfolate relies on B12 to convert it back to Tetrahydrofolate via Methionine Synthase, and Tetrahydrofolate then goes into production/synthesis of many things, including Tetrahydrobiopterin which is the necessary co-factor for synthesis of neurotransmitters via the Hydroxylase enzymes that convert Tryptophan to 5-HTP and Tyrosine to L-Dopa, and then B6 is needed by the AADC (Aromatic Amino Acid Decarboxylase) enzyme to convert the 5-HTP and L-Dopa into Serotonin and Dopamine.

With the Methylfolate, you will notice the increase in neurotransmitters, it's used standalone but is also mixed with anti-depressants especially for people who don't respond much to anti-depressants or what not. Together with the Rue, Methylfolate brings the power back. What's happening, most likely, is that because you're inhibiting MAO-A, you probably need more Tryptophan and/or Tyrosine or what not, and so adding the Methylfolate to the Rue will ime/imo give you the anti-depressant effect you're probably looking for.

Granted, there are some effects of Rue that do indeed go away, but what i've come to associate as the anti-depressant feeling of the MAO-A inhibition in general, is still no doubt there, even years down the line of daily use, MAO-A inhibition seems to always work, but we need to give our bodies the nutrients and neurotransmitter precursors they need to produce more neurotransmitters. As for the other effects of Rue, there's probably some benefits there, but ime Rue stays beneficial and teaching and really pretty cool even with those effects going away.

Another thing you can try is finding some nice herbal teas or supplements (which technically Methylfolate and B12 and the other B vitamins fall into that category) and mixing them with the Rue to flavor things in various ways and to add different benefits or aspects to it.

But yeah the magick of Rue sticks around, it just goes more into the background with regular consumption and it's up to you to bring it out, ime. Earlier when i was eating some chicken wangs an hour into my 2 gram Rue dose, i had some pretty surreal moments while eating where it was like intimate, i was really goin' at the chicken lol, and the Rue was like acting shamanic in a way, hard to describe but it was cool lol, granted i do have some other things in the mix at the moment so that probably contributed but none the less Rue works pretty well, you just gotta play around with it.

Also it's good to keep in mind that as you consume the Harmalas/Rue regularly, you get deeper and deeper into the Harmala effects, and as you get deeper into the Harmala effects things can get a bit sedating and dreamy and that can kinda bring you down a bit ime, so you may try adjusting the dosage a tad to keep it within a certain range, so as the Harmala content gets stronger and you reach a point where it doesn't particularly feel "good", lower the dosage just a tad and see how that goes. There is a certain range with Rue/Harmalas where it's more beneficial and anti-depressant-like, but beyond that it can get pretty heavy. But again with regular consumption it does clean up in it's effects and it's not as heavy but it can still be a wee bit intoxicating for sure, especially with Cannabinoids in the mix lol. Which, idk if you partake, but Cannabinoids with Rue/Harmalas go hand in hand, it really brings out the Rue's effects.
 
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In my experience with taking harmalas daily, I’ve also noticed an apparent decrease in the antidepressant effects, but less so the sedating ones. Offsetting the harmala sedation with guayusa seems to have its own synergistic antidepressant effect, however, particularly in combination with cannabis. It seems like the harmalas increase my tolerance for caffeine by at least a factor of two, if not more, while also negating it’s negative side-effect. The overall effect is of being able to drink approximately twice as much gauyusa as I typically would, thereby offsetting the harmala sedation without feeling overstimulated from too much caffeine. Conversely, harmalas seem to potentiate cannabis while making its effects last considerably longer, which I also appreciate and enjoy.
 
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