Science paper Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence , Cambridge University 2025[word candy]

Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence [[Cambridge Univ.]]
If you take the time to read this study you will be treated to paragraphs such as these:
Upon activation of the 5-HT2A receptors, psychedelics trigger a cascade of intracellular signalling pathways, particularly involving the phospholipase C (PLC) pathway. This pathway subsequently increases the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), leading to the release of calcium ions from intracellular stores (Raote and Bhattacharya, Reference Raote and Bhattacharya2020).
The activation of 5-HT2A receptors by psychedelics modulates the excitability of cortical neurons and influences synaptic plasticity. These mechanisms underpin the profound changes in consciousness and perception these substances induce (Preller and Vollenweider, Reference Preller and Vollenweider2019).

 

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I really hope that these studies end up with the legalization or decriminalization of these fungi that clearly help so many people. I just wish people would agree that the Nixon administration sucked and the laws they passed were to destroy the opposition.

 

[JungleGhost]

Thanks for posting!

 

[Varallo]

Thank you for posting this study.

What I mainly read here is moderately competent science based on interpretations, with rather strong statements made to promote the popular narrative that psychedelics are a solution for depression. It makes me sad, because studies like this don’t do the field much good and mostly show that it’s still in its infancy. The problem is that there’s so much to remark on that it’s hard to take it very seriously. Perhaps it’s best seen as a study of narrative rather than of the claims made.

Maybe it’s time to take some action and write the editor a serious letter.