Harold the Hoot
Rising Star
Hello folks, I had a couple of chemistry questions, and I noticed several of you folks have a really advanced knowledge (particularly in synthetic chemistry). My background is in p-chem, mostly spectroscopy. So, I had a solid (academic) understanding of organic, but limited real world experience.
I was reading up on some interesting papers on preparing DMT and 5 Meo-DMT using the Fisher Indole synthesis. I found the mechanism, and I think I understand it. The issue is, I found a batch synthesis for the 5Meo, but a continuous flow prep for DMT.
Here is the continuous flow paper: (for DMT) Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential
And here is the batch prep: (for 5-Meo) Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use - PMC
The chemistry appears to be very similar. However, the 5Meo batch reaction was carried out at 40C (3hr), while the continuous flow reaction proceeded at 140C, with a 10 min "residence time" (in H2O solvent).
To do the batch process for DMT rather than 5Meo-DMT, it seems like one could just use the DMT precursors ( phenylhydrazine hydrochloride and 4-(dimethylamino)butyraldehyde diethyl acetal) rather than the 5Meo (4-methoxyphenylhydrazine and 4,4-diethoxy-N,N-dimethylbutan-1-amine), and bring them to 140C for 10 minutes. It would require some sort of pressurizable reactor (as water boils at 100C), but otherwise, it should be as simple as that, shouldn't it?
I'm asking as an academic question. I'm an old man, and haven't been in the lab for a lot of years.
Thanks for any thoughts on the matter.
I was reading up on some interesting papers on preparing DMT and 5 Meo-DMT using the Fisher Indole synthesis. I found the mechanism, and I think I understand it. The issue is, I found a batch synthesis for the 5Meo, but a continuous flow prep for DMT.
Here is the continuous flow paper: (for DMT) Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential
And here is the batch prep: (for 5-Meo) Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use - PMC
The chemistry appears to be very similar. However, the 5Meo batch reaction was carried out at 40C (3hr), while the continuous flow reaction proceeded at 140C, with a 10 min "residence time" (in H2O solvent).
To do the batch process for DMT rather than 5Meo-DMT, it seems like one could just use the DMT precursors ( phenylhydrazine hydrochloride and 4-(dimethylamino)butyraldehyde diethyl acetal) rather than the 5Meo (4-methoxyphenylhydrazine and 4,4-diethoxy-N,N-dimethylbutan-1-amine), and bring them to 140C for 10 minutes. It would require some sort of pressurizable reactor (as water boils at 100C), but otherwise, it should be as simple as that, shouldn't it?
I'm asking as an academic question. I'm an old man, and haven't been in the lab for a lot of years.
Thanks for any thoughts on the matter.
