I have,  melatonin had no effect.  The only time I break through is when using Diphenhydramine Hydrochloride (Benadryl)  as a sleep agent. I tried the doxy succinate (unison)  to see if that would work.  Still no luck.  For some reason Benadryl seems the only thing that overrides my brain chemistry enough to break through. I'm hoping someone has encountered the same or similar and has come up with a solution. Seems to be a bit deeper than just taking a break from it.