Hi, I wanted to respond as I also take amlodipine daily. 5 mg like you. While I’m not encouraging you to do anything you do not feel comfortable with I will say that I have been vaping dmt and have had no hypertensive scares. My situation could be different than yours. I have had slightly elevated BP my whole life. Around 130/85. I’m slightly overweight but am physically fit and active. Ive been dealing with some medical issues that are moot so I won’t get in to them but my BP was higher 3 dr visits in a row (150/90), so I’m on amlodipine now. My resting BP is now around 116/70.
I check my BP before I partake in psychedelics now. If it’s normal I go through with it. I have taken my BP while at the peak of 15 mg and it was only 140/70. I look at it like this: I regularly subject my cardiovascular system to way more stress for longer periods of time through workout so I’m not really worried about the stress from dmt in that aspect.
I have also spoken to some people on another forum that take a calcium channel blocker (amlodipine is a calcium channel blocker) prior to taking psychedelics as a safeguard due to being older and having high Bp. Anyway what I’m trying to get at is if your bp is under control while taking amlodipine and you are generally healthy then I would say you are probably fine. But only you can make that decision for yourself.
DO NOT take an MAOI while on amlodipine. This could cause dangerously low bp.
Also a little side note. I have noticed that amlodipine seems to suppress some of the physical fear responses I used to get while taking psychedelics. I need to do more investigation into this as I can’t seem to find any literature to back this up. But this article is an interesting read. Not dmt but still.
Ca2+ channel blockade prevents lysergic acid diethylamide-induced changes in dopamine and serotonin metabolism - PubMed