[VIDEO]Hamilton Morris and Elias discuss tellurated psychedelics - and their SUCCESSFUL(?) synthesis

[Transform]

Unexpected crossover? Or chemists being chemists?

(check it at 26:45 as well…)

 

[Varallo]

Truly one of the more enjoyable videos I’ve seen recently. Very inspiring to also see that alternative elements are being used and that there’s this kind of search going on by a few people in this field. Even though I’m not a chemist myself, it still makes me feel enthusiastic. Especially the part that’s mentioned at the end about substances that influence lucid dreaming and tryptamines and the unexplored chemistry surrounding that. Super inspiring to dive a bit deeper into, and maybe even try out a few experiments. Especially because it’s still all in a legal area. And that, of course, makes it twice as interesting.

Thank you for sharing this video. I think I probably would’ve missed it otherwise. But it was a real pleasure.

 

[Transform]

Truly one of the more enjoyable videos I’ve seen recently. Very inspiring to also see that alternative elements are being used and that there’s this kind of search going on by a few people in this field. Even though I’m not a chemist myself, it still makes me feel enthusiastic. Especially the part that’s mentioned at the end about substances that influence lucid dreaming and tryptamines and the unexplored chemistry surrounding that. Super inspiring to dive a bit deeper into, and maybe even try out a few experiments. Especially because it’s still all in a legal area. And that, of course, makes it twice as interesting.

Thank you for sharing this video. I think I probably would’ve missed it otherwise. But it was a real pleasure.

Yes - once I'd got settled in and screened out the background noise from the inverview being recorded in a real working lab it got more and more fascinating and inspiring. I went so far as sketching an outline synthesis for the main difficult step of getting the intermediate benzo[1,2:4,3-b:b']difuran (or however you'd systematically name it) for the "G-FLY" hybrid analog that Hamilton mentions later in the video. I'll have to post that here in a bit and hope that Hamilton gets to see it. There are some very interesting directions that intermediate can be taken in. I'd argue it might be more interesting than the doom-like horror of working with tellurium
Then again, it would be rather amusing (in the warped mind of a chemist, at least) if the key to successful (ridiculously challenging) production of a tellurated psychedelic lay in combining it with the similarly taxing G-FLY substitution pattern. I already have a structure in mind

One small point of nomenclatural pedantry for Hamilton (I know, poor chap was very tired) but the various times where the term "tellenyl" was used - presumably in analogy with "selenyl" - it would be more accurate to use "telluryl" unless, perhaps, speaking analogously about tellurium versions of selinyl (seleninyl?) derivatives. On the other hand, organoselenium nomenclature's already horrible, so there's no reason for organotellurium to be less worse, especially if we follow the analogy with the amount known about structure-activity relationships through the series of chalcogenated phenethylamines.
[Edit: see next post]

Yeah, I tend not to talk about chemistry in polite circles.

 

[Transform]

On second thoughts, maybe the analogy with sulfuryl - which is the dioxygenated, hexavalent sulfur moiety as in sulfuryl chloride - does imply that tellinyl is in fact a better term for a divalent organotellurium substituent. Sorry to have doubted your thoroughness, Hamilton!