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Research Miprocin and Metocin in PG solubility, stability and vaping observations

Research done by (or for) the DMT-Nexus community

Varallo

Chiaroscuro
Senior Member
Warning
This report is for informational purposes only. Both 4-ho-mipt (miprocin) and 4-ho-met (metocin) are relatively unknown psychedelic tryptamines. Vaping is an untested and potentially unsafe route of administration. There is no toxicological data on pyrolysis products, long term health effects, or safe thresholds for vaporized 4-ho compounds. Proceed only if you are fully aware of the risks.


1. Background

A few months ago I was wondering whether miprocin and metocin could be dissolved in propylene glycol for use in a vape. 4-AcO-DMT/4-HO-MET Fumarate water solubility I had been thinking about it but hadn’t seen any real data, so I decided to test it myself. Over the past few months I’ve been experimenting with solubility, visual stability, and subjective effects using small stick-style vape device.

2. Materials
  • Compounds:
    • miprocin (4-ho-mipt), fumarate salt
    • metocin (4-ho-met), fumarate salt
  • Solvent: standard propylene glycol for vaping
  • Concentrations tested: 75 mg per mL, though based on subjective intensity I would now recommend increasing to 120–150 mg per mL for practical dosing, note: 100 mg was easily dissolved in one ml of pg.
  • Vape device: small portable vape (non-sub-ohm)
  • Storage: glass bottles, room temperature, dark place
  • Test duration: approximately 2 months

3. Observations

Solubility and appearance
Both compounds dissolved easily in propylene glycol with a little heat. The solutions stayed clear and stable at room temperature pH is neutral is slight acidic.
  • Miprocin: minimal color change over 2 to 3 months, slower than degradation seen with dmt citrate in pg slight tan hue.
  • Metocin: slight yellowing, possibly faster than miprocin, but no clouding or rapid degradation like in water.

Vape effects

Both where tested in a small vape with new coil, in low doses.
  • Miprocin: very smooth to inhale, no throat irritation. Comes on rapidly, first effects noticeable within 30 seconds. Warm, soft body feel, calm introspective onset. Takes several pulls to build up. Did not yet go higher in dosage yet, hopefully in the near future.
  • Metocin: lighter and brighter. Effects are more pronounced visual sharpening and a slightly euphoric tone. Also fast in onset. Metocin is nice but is lacking in some areas for me so it was more tested to check if it would work.

4. Dosage advice

At 75mg per mL, multiple pulls were needed to reach a threshold effects. For more practical use, especially in small travel-sized vapes, I would recommend going up to 130 or even 150 mg per mL. Of course, start low and work up slowly, effects tend to build a bit slower as compared to DMT, plus vaporized dosing is much harder to dose accurately than oral.

5. Final thoughts

This method works. Both compounds are active and seem relatively stable in pg. The onset is rapid and the effects are very noticeable. If you are going to explore this, be careful, be conservative, and don’t treat the lack of negative reports as proof of safety. This is still very much experimental territory. For now I’m going to finish my experimental vapejuice and maybe try an higher dose when the time is there. One datapoint that is missing is the duration, sorry, I got enthusiastic after vaping and after some time continued vaping DMT ontop, so when effects where gone and out of my system is still unknown.

Note: I also successfully dissolved both in VG, and in an 50/50 mix, though they where not vaporized.
 
I wanted to try this myself for a while, but was thinking about freebasing 4-HO-MET fumarate beforehand. Did the fumarate salt have a weird taste when vaped? Have you considered the formation of maleic anhydride when vaping fumarate salts? I'm thinking it would only be a very small amount, but vaping maleic anhydride still doesn't sound good.
 
I wanted to try this myself for a while, but was thinking about freebasing 4-HO-MET fumarate beforehand. Did the fumarate salt have a weird taste when vaped? Have you considered the formation of maleic anhydride when vaping fumarate salts? I'm thinking it would only be a very small amount, but vaping maleic anhydride still doesn't sound good.
I don't know if anyone is 100% certain, but the going theory is that the operational temperature for vape cart devices is below the combustion threshold of fumaric acid. I may be incorrect on the specifics as I'm a dunce in chemistry, but I think that's the gist of it.

 
I wanted to try this myself for a while, but was thinking about freebasing 4-HO-MET fumarate beforehand. Did the fumarate salt have a weird taste when vaped? Have you considered the formation of maleic anhydride when vaping fumarate salts? I'm thinking it would only be a very small amount, but vaping maleic anhydride still doesn't sound good.
I have freebased both, but you end up getting an oily mess that is rather unpleasant to work with. As to malieic anhydride, I feel that this is something that is not going to form when vaping PG at normal temperatures. It’s not like you’re smoking it, the idea of vaping with PG is that you’re creating an fine mist of PG with the active ingredient dissolved into the mist.

As to the taste it has a slight tryptamine taste reminiscent of DMT but much weaker than DMT. Absolutely no discomfort whatsoever was noted during or after the experiments. For reference I can’t smoke an single cigarette without feeling like I need an rescue inhaler to breathe.
 
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