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Voacangine conversion to ibogaine

Migrated topic.
TA I'd assume. Limtek extraction salted to fumerate for one batch and hcl for another. Half of the fumerates were converted to freebase, drytek with sodium carb and annhydrous acetone. If anyone knows how I can purify I'll be happy to give that a go I got hcl and I can run down and grab some KOH.
 
How to they isolate Ibogaine from TA/root? One would assume the same procedure would work to isolate Voacangine from voa TA/root. Apologies for not just doing the research for myself, I will when I get the chance, but if someone knows off the top of their head that would be awesome!
 
ibogaine is often isolated with a little bit of residual ibogamine by dissolving PTA freebase in acetone and adding conc. hcl to precip ibogaine hcl. Ibogaline and the other most abundant alkaloids are more soluble in hcl form in acetone.

According to Chris Jenks, voacanga rootbark has about 10 percent alkaloid content, of which only 3 percent is actually voacangine.

Best to source some iboga root bark imo.
 
Thanks!

Rather unfortunate this is not a workable method :/ I've been trying to find a useful purpose for this voacanga for ages. Guess I'll just have to make some arrow poison or something with it :p
 
Dagger said:
Found this on the net:
This patent goes on to explain how to turn voacangine into ibogaine by
treating it with potassium hydroxide in boiling alcohol, followed by
warming it with dilute acid.
Click to expand...

Voacangine comes from the african tree Voacanga africana.

Since ibogaine and tabernanthe iboga is quite expensive, perhaps it would be an idea to convert voacangine into ibogaine?

Ibogaine is a pretty rough experience, but I have read that it is great in low doses as a therapeutic aid. Supposedly can give insightful dreams. And this is with doses 10 times lower than a hallucinogenic dose.

Hopefully someone on this forum could try it out. Not quite sure how to separate it from the rest of the alkaloids etc. in voacanga africana though.
Click to expand...


SOo,....Voacanga Africana > voacangine > base > acid > IBOGAIN (and other alkaloids)

SoO, .....How can you extract the voacangine from plant material ?? (anyone tried this)
 
This is from Dr Chris Jenks, after asking about using limonene and then acetic acid to extract the alkaloids from iboga root bark.

"In my own studies, acetic acid doesn't remove alkaloids from root bark as fast as dilute HCl does, but I don't know if that matters in extracting alkaloids from solvent. Actually, based on my recent work with Voacanga, I would expect acetic acid to be most likely to leave behind voacangine in the limonene extract because that is the least basic alkaloid. That's not a bad thing since voacangine seems to only cause stomach aches."

So it seems like the voascangine is, or can be, a source of the stomach cramps. But for Voacanga extraction for ibogaine conversion, it is interesting to note that voascangine is the least basic alkaloid, in iboga at least. So this may be worth knowing with regard to choice of solvents used in extraction, not sure how one would go about purifying it though.
 
Yes yes, off topic, but funny as hell:
[quote='Coatl]Ibogine is mentioned in "Fear & Loathing in Los Vegas"?

[/quote]
Ed%20Muskie%20Ibogaine%2072.jpg
 
Rigth on Bancopuma, thanks.
What the ratio in weight of voacangine to ibogaine ? 1:1 ?
 
If one was to extract a bunch of voacanga rootbark into limo and salt it out with vinegar, the voacangine would remain in the limo?

Would this also be the case with xylene or toulene as well and the freebase voacangine could be retrieved via evaporation for conversion into ibogaine?

Would one be able to salt the limonine with a stronger acid like hcl after the vinegar salting and retrieve the voacangine hcl for conversion?

This sounds quite promising
 
That would be the first steps to check out, if one had voacanga to give to these investigation.
Check this with maybe TLC control, to see where the voacangine goes/stay.
 
I put your questions to Chris Jenks, and this was his reply...


"All your questions were addressed last year at the ibogaine conference in Vancouver:



In short, your understanding is correct. You can extract powdered Voacanga bark with a non-polar solvent and remove most of the more basic alkaloids with weak acid like dilute acetic acid, then remove the weak bases like voacangine with a strong acid like HCl. Bob Sisko uses toluene for the initial extraction of root bark, showing that this is feasible. However, on the scale needed to make a difference in the market it would be much more economical to extract the bark with strong dilute acid and recover them by precipitation with base - or make the extract less acidic and extract out voacangine directly. The only other thing I would like to emphasize, although it is covered in the above presentation, is that these extractions need to be repeated to be efficient, just as the extraction of iboga bark with dilute acid is best repeated at least six times."
 
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