cannabis
I have a love/hate relationship with this plant. Under the influence of cannabis I loose all logic reasoning, and it makes me totally introverted. This can be good and bad I guess. For enjoying music it's nice, or playing the guitar, or painting.... Social interaction become a pain and feel like a waste of time when I'm high. I can't imagine vaping in the morning and going to work, OMG that would get my ass fired asap. To be honest I prefer groing the plant over smoking it. Oh yeah, it's very destructive for my sex drive....music seems so much more interesting then sex when I'm high. 
cocaine
Not my cup of tea. It feels like drinking 10+ cups of coffe at once (I don't like coffee). It makes me feel anxious and gives an uncomfortable body load. I dunno maybe the stuff you get here is only 5% cocaine and 95% garbage.
MDMA
I used to take a lot of XTC when I was younger, and go out raving. It was great, the music took on a whole other dimension, and I felt very good and socially outgoing. MDMA opens me up and I feel very balanced and warm. I love deep conversations on MDMA, normally I am rather quiet and introverted. Feel a bit heavy on the body and mind the days after though.
I rarely take it nowadays because I've got acid in my fridge! 
amphetamines
Once when I was younger I had a terrible panic attack on speed. Basically my mother had to bring me to the ER, and they gave me some valium, and they kept me for 3 days. That was pretty embarrassing. I cannot handle stimulants....
alcohol
Can be nice when used in moderation. If I drink too much I get out of control. Nowadays I rarely drink, maybe once every 2 weeks. I have an alcoholic mother so I'm very aware of the damage it does.