I have never smoked bufotenin, so i can't tell about that compound. I have some vilca, but haven't found the time yet, to extract the bufotenin. The calmness of ayahuasca makes it mentally very 'safe', i think.

Oral cannabis can give you trips as heavy as with LSD. Some people cannot stand it and become totally paranoïd, but it makes me feel so comfortable that i don't think bad trips are likely to occur. And when they do, the tranquility induced by it would make it easy to get out of the negativity.