yes most certainly there are compounds that are more likely to cause a bad trip...i think the interesting part about dmt is that even at extremely high doses(oral) you seem to be stripped of who you are..so its hard to freak out when there is no 'you' to freak out about...and SWIM also finds dmt a bit more sedated with maoi's compared to LSD..

also here is another idea..how easy is it to drink ayahuasca? and how easy is it to smoke dmt? its not. when you smoke dmt..its like you have to force yourself to do it..you have to stay conscious and determined long enough to get enough in you...and aya is gross tasting...and you have to brew it up..and it takes time and effort to do..

on the other hand..there is LSD..all you have to do is put a hit in your mouth..and its in you..just like that..no taste...no work making or preparing the chemical..there seems to be no ritual behind taking it...