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When was DPT first synthesized and by whom?
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..clouds..was it in Italy by Vitali & Mossini in 1959?..i don't have the paper [ Vitali T. & Mossim, F. (1959). Preparation of some N-substituted tryptamines. Boll. sci. Fac. chim. Ind. Bologna ], but it is referred to along with DPT in this very interesting chemistry paper on tryptamine derivatives from the UK military in 1964 which i have attached for members..
This has sent me on a binge of reading errowid DPT reports. Oh boy, do people love to make the same mistakes over and over. "I eyeballed the stuff", "I am an experienced psuychonaut so I was sure I can handle anything", etc etc, full of people snorting then calling ambulance.
Then I jumped over to 5meo reports and damn, people are VERY misinformed on "do"s and "don't"s, dosage, blasting off alone with it. One "recent" report is from guy who thought he got N'N and vaped 50mg of 5meo...
Though every "bad" trip seem to have instilled deep respect in all participants
))
Then I jumped over to 5meo reports and damn, people are VERY misinformed on "do"s and "don't"s, dosage, blasting off alone with it. One "recent" report is from guy who thought he got N'N and vaped 50mg of 5meo...
Though every "bad" trip seem to have instilled deep respect in all participants
))
clouds
Human
nen888,
Stephen Szara in his paper "DMT (N,N-DIMETHYLTRYPTAMINE) AND HOMOLOGUES: CLINICAL AND PHARMACOLOGICAL CONSIDERATIONS" wrote this:
"Speeter and Anthony (1954) reported that N,N-dipropyltryptamine (DPT), another tryptamine derivative, produced observable effects in dogs."
Stephen Szara in his paper "DMT (N,N-DIMETHYLTRYPTAMINE) AND HOMOLOGUES: CLINICAL AND PHARMACOLOGICAL CONSIDERATIONS" wrote this:
"Speeter and Anthony (1954) reported that N,N-dipropyltryptamine (DPT), another tryptamine derivative, produced observable effects in dogs."
clouds, i stand corrected..the mystery continues..maybe it was Manske 1929?
clouds
Human
nen88,
I spent a whole day searching for this. Half of the sources say 1950 and the other half say the 1950's. It was defintely before 1954, since Merrill Speeter could have easily synthesized it, he was a very skilled chemist.
I also believe it could have been synthesized around 1930's as DMT was, but who knows.
The mystery remains.
I spent a whole day searching for this. Half of the sources say 1950 and the other half say the 1950's. It was defintely before 1954, since Merrill Speeter could have easily synthesized it, he was a very skilled chemist.
I also believe it could have been synthesized around 1930's as DMT was, but who knows.
The mystery remains.
..it's good you sparked the search for the unknown, clouds, and i admit i just jumped to what was at hand...i noticed there is a Speeter 1955 chemical abstracts paper i can't presently access that may have clues..
Speeter, M. E. (1955). U.S.P. 2,708,197, ChemicalAbstracts, 1956, 5035.
..it seems it's the patent for the synthesis of tryptamines and production of a range of various novel tryptamines, which i haven't had time to look at in detail... US2870162A - Production of certain tryptamines and compounds produced in the process - Google Patents
(apologies time in my writing only allows me a quick stab at this issue...the theory on military wartime invention is a good one..i also would have imagined Manske coming up with it..hope you find the answer clouds!)
..it seems it's the patent for the synthesis of tryptamines and production of a range of various novel tryptamines, which i haven't had time to look at in detail... US2870162A - Production of certain tryptamines and compounds produced in the process - Google Patents
(apologies time in my writing only allows me a quick stab at this issue...the theory on military wartime invention is a good one..i also would have imagined Manske coming up with it..hope you find the answer clouds!)
UgraKarma
Esteemed member
DPT has always been charged negatively for me (and by that, I mean, it lends itself towards a dread similar to a salvia divinorum overdose.) Having worked through various dosages and ROAs, I'd decided it might be the most unsettling tryptamine I've worked with. YMMV.
love/light
love/light
clouds
Human
Update:
Seems like Merrill Speeter could very well have been the first or (one of the firsts to synthesize it)
-> Wikipedia says that DPT was firstly reported in 1973.
but the first report is from this paper:
Speeter, M. E., & Anthony, W. C. (1954). THE ACTION OF OXALYL CHLORIDE ON INDOLES: A NEW APPROACH TO TRYPTAMINES. Journal of the American Chemical Society, 76(23), 6208–6210. doi:10.1021/ja01652a113
if you read the second page (or page 6209) you can find the following text:
Footnote No. 5:
"Studies by Dr. Nolen Connor of our Laboratories indicate the hydroxyl group is not essential for activity on the central nervous system as 3-(2-dimethylaminoethyl) indole has grossly the same action in the dog as bufotenine. In contrast, 3-(2-methylaminoethyl)-indole has slight activity while 3-(2-N-propylaminoethyl)-indole produced no apparent symptoms.
According to pubchem, 3-(2-(Dipropylamino)ethyl)indole is DPT itself.
Also, the following:
THE COMPARISON OF THE PSYCHOTIC EFFECT OF TRYPTAMINE DERIVATIVES WITH THE EFFECTS OF MESCALINE AND LSD-25 IN SELF-EXPERIMENTS
Szara writes: "The N,N-dimethyltryptamine (DMT) and the N,N-diethyltryptamine (T-9) were obtained synthetically by the method of SPEETER AND ANTHONY."
Note that N,N-diethyltryptamine is DET itself.
So, Szara admits he used the Speeter method.
And Speeter says something about studies of a "Dr. Nolen Connor".
Did Connor just supervised the study or was he the chemist? In any way, DPT has been used since 1954 and seems like Speeter was perfectly capable of synthesizing it.
extra edit: both Merrill E. Speeter and Dr. Nolen Connor were prominent figures in The UpJohn Pharmaceutical Company.
Seems like Merrill Speeter could very well have been the first or (one of the firsts to synthesize it)
-> Wikipedia says that DPT was firstly reported in 1973.
but the first report is from this paper:
Speeter, M. E., & Anthony, W. C. (1954). THE ACTION OF OXALYL CHLORIDE ON INDOLES: A NEW APPROACH TO TRYPTAMINES. Journal of the American Chemical Society, 76(23), 6208–6210. doi:10.1021/ja01652a113
if you read the second page (or page 6209) you can find the following text:
Footnote No. 5:
"Studies by Dr. Nolen Connor of our Laboratories indicate the hydroxyl group is not essential for activity on the central nervous system as 3-(2-dimethylaminoethyl) indole has grossly the same action in the dog as bufotenine. In contrast, 3-(2-methylaminoethyl)-indole has slight activity while 3-(2-N-propylaminoethyl)-indole produced no apparent symptoms.
According to pubchem, 3-(2-(Dipropylamino)ethyl)indole is DPT itself.
Also, the following:
THE COMPARISON OF THE PSYCHOTIC EFFECT OF TRYPTAMINE DERIVATIVES WITH THE EFFECTS OF MESCALINE AND LSD-25 IN SELF-EXPERIMENTS
Szara writes: "The N,N-dimethyltryptamine (DMT) and the N,N-diethyltryptamine (T-9) were obtained synthetically by the method of SPEETER AND ANTHONY."
Note that N,N-diethyltryptamine is DET itself.
So, Szara admits he used the Speeter method.
And Speeter says something about studies of a "Dr. Nolen Connor".
Did Connor just supervised the study or was he the chemist? In any way, DPT has been used since 1954 and seems like Speeter was perfectly capable of synthesizing it.
extra edit: both Merrill E. Speeter and Dr. Nolen Connor were prominent figures in The UpJohn Pharmaceutical Company.
Dead thread, but I found something interesting.
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DPT
N,N-Dipropyltryptamine (also known as Dipropyltryptamine, DPT, and "The Light") is a lesser-known psychedelic substance of the tryptamine class. It is closely related to DMT and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and...
psychonautwiki.org
One love