Yopo. snuff. Insufflation.

[Explorer2023]

This is a discussion about snuff method of psychadelic use. Namely mapacho tobacco (nicotine), Yopo (anadenanthera) dmt containing plant seeds, peganum harmala (surian rue), and similar.

First of all just want to say the snuff method I find little information online. It is my current inspiration after a longtime break from dmt induced consciousness altered states.

I have tried and mingled in varied extraction techniques in the past, with little success but alot of experimentation and learning.

I just want to say how easy the snuff technique is, I think it has a place in the psychadelic space.

Smoking DMT is very fast acting, drinking ayahausca is slow acting and long time. Snuffing/ insufflation is somewhere in the middle. Very pleasant.

Yopo is made from a dmt containing seed, with very simple preparation method.
Simple cook the seeds until pop, de-hull the seed, cook a little more until dry and crispy and then grind to fine powder. Add some calcium hydroxide and distilled water and knead into a paste, flatten out and let dry out. Preparation time about 1 hour but then let it sit for upto 24 hours before snuffing.

It has strong effects.

Also I've snuffed 600 mg of ground syrian rue seeds 1 hour before yopo and potenciates the effects of dmt. When using syrian rue half the dosage of dmt you would usually take.

I'm new to this forum and hard to type ect on my phone buy will be discussing more on the subject of insufflation of alkaloids in the future.

 

[Explorer2023]

I searched the internet and couldn't find any information on snorting syrian rue, so I experimented myself.
I ground the seeds, heated a bit to make dry and crispy, ground it some more. I snuffed 600 mg in total. Using kuripe pipe. 150 mg in each nostril, twice, about one hour apart.
I never had any MAOI so was new experience and could definitely feel a shift from baseline, almost like having 4 beers.
I then snuffed 50 mg of yopo seeds powder I prepared earlier and relaxed into my hammock to ride the experience.
I've only just started building a relationship with this seed and method, entering the depths on consciouness again after years so taking my time.
The day prior I had 100mg of yopo with no rue, this time I had 50 mg yopo and 600 mg of rue and it was just as strong if not a little more intense.
100 mg is very small light dose, just dipping my toes into the water at the moment.
I will be going deeper in time.

The take away of this message is snuff is reliable and an easy dmt technique.
Also snuffing syrian rue is viable administration method. It potenciates effects.
Yopo is easy to prepare.

The photo is yopo seed powder.

 

[Explorer2023]

I started snuffing tobacco first which got me used to the method of ingestion/administration through insufflation. I have got mapacho plus ash mix and use kuripe pipe. It has a bit of a kick/sting to the nostril which I like.
I then got interested in psychadelic snuff.
Yopo seeds are smooth and easy to prepare, yet powerful.
I read online that you must use calcium hydroxide to convert the bufotoxin into 5meo-dmt otherwise will get sick. I ordered the Calcium hydroxide from a home brew shop.


If you have any thought or experience with insufflation please share it here.
Have you tried yopo?
Have you snorted syrian rue?
Do you sniff rappee?

 

[downwardsfromzero]

Hello, thanks for sharing, and welcome to the Nexus<

Have you encountered J. Ott's essay, "Pharmañopo - Entheogenic Errhines", which covers this topic? You should be able to dig out details on the forum here.

I've snorted extracted harmala citrates and it's an effective and IME comfortable ROA. It's more convenient than snuffing whole seed material as well, but probably not wholly comparable to the full-spectrum effects that you'd get from the seeds. I have occasionally sniffed small amounts of rue seed powder after grinding them up for quick-brewing purposes but not in any significant amount. Nor have I followed up the harmalas wiih any tryptaminic material (or mescaline, for that matter) but the idea seems possibly to be worth a try.

DMT freebase was horrifically painful to administer intranasally, so I'd be more inclined to use something like the fumarate or the benzoate. It's a shame the citrate tends to be gooey, otherwise that would be a good candidate material for experimentation. Nor would I be particularly inclined to try, say, mimosa powder in lieu of yopo seeds as it's probably a bad idea to snort sawdust. (Not saying that you do, just exploring the idea myself!) I haven't snorted rapé either.

I don't think calcium hydroxide will convert bufotenine into 5-MeO-DMT. There would need to be a source of methyl groups in the seed material, which sounds a bit frightening! It seems rather more likely that the lime destroys a nauseating impurity or alters the bioavailability of bufotenine in such a way that the nausea is reduced.

What do you think of snorting extracted material?

Looking forward to hearing more of your experiences - subjective, qualitative and quantitative.

 

[Explorer2023]

I don't think calcium hydroxide will convert bufotenine into 5-MeO-DMT. There would need to be a source of methyl groups in the seed material, which sounds a bit frightening! It seems rather more likely that the lime destroys a nauseating impurity or alters the bioavailability of bufotenine in such a way that the nausea is reduced.

Ah yes this is from the source material. Anadenanthera_peregrina

calcium hydroxide will react with bufotenine and replace the hydrogen bond at the five position of bufotenine (5-HO-DMT) with calcium, forming Ca + 5-O-DMT, also known as calcium bufotenate (or calcium bufotenoxide). This is a common chemical reaction that occurs with all phenolic compounds when reacted with calcium hydroxide for expended periods of time (see phenol for more information). Several hours are needed for the reaction to take place. Ca + 5-O-DMT is less toxic, and produces effects more like DMT and Psilocin than the classic toxic effects of bufotenine. Its effects last normally 2-3 hours. After kneading, it is then left to sit for several hours to several days, depending on the local customs. During this period most of the excess calcium hydroxide reacts with the carbon dioxide in the air to form less caustic calcium carbonate (carbonatation). The more modern non-traditional use of baking soda or ammonia as a substitute for calcium hydroxide has been used with limited success

Bufotenin and Ca + 5-O-DMT

Bufotenine is the main active constituent of unprocessed yopo. Modern tests, prepared by the DEA and others, have shown that only bufotenin is present in active amounts in the beans. It must be noted that because bufotenine is a phenolic compound, the lengthy snuff processing with calcium hydroxide converts bufotenine into Ca + 5-O-DMT (calcium bufotenate/bufotenoxide). Ca + 5-O-DMT is a hallucinogen like DMT and psilocin and very unlike bufotenine. Snuff prepared without calcium hydroxide will contain large amount of bufotenine and no Ca + 5-O-DMT, and will produce nausea, tension, and a completely different hallucinogenic effect very unlike DMT and psilocin. Snuffs made with ammonia and other weak bases instead of calcium hydroxide, will create free base bufotenine and not Ca + 5-O-DMT. While free base bufotenine is psychoactive, it is very unlike DMT and somewhat toxic. Shamans typically prefer the effects of Ca + 5-O-DMT over bufotenine. This is why most shamans prepare yopo snuff using up to 33% calcium hydroxide and allow it to react overnight, kneading it over and over to ensure that all the bufotenine reacts with the calcium hydroxide.

The beans have been found to contain up to 7.4% bufotenin.[30] At up to 7.4 % (74 mg per gram) bufotenin, an effective 40 mg dose of insufflated bufotenin[30] requires little more than 0.5 grams of beans.

 

[downwardsfromzero]

Yes, the phenolic deprotonation by is fine and dandy and discussed on the forum, but that bufotenide is gonna have a hard time crossing the BBB without active transport. [Edit: dehydrobufotenine is something which receives too little attention in this context - not to mention nordehydrobufotenine, where there are hints at substantial potency tucked away in the literature.] I'd say we're still dealing with unknowns here, cos 5-MeO-DMT it ain't, even if we're imagining endogenous methylation or other transformation at the phenolic O atom.

It's an exciting mystery that I'd love to see investigated more deeply - just what is going in with all this? Is this another task for... Brennendes Wasser? :lol:

That hypothetical complex looks as though it could fit the bill for… something. But what?
[Edit: here's some further discussion of "calcium bufotenate".]


PS 69ron is, sadly, a notorous fraudster so you'll have to regard his assertions with a healthy dose of skepticism.

 

[Explorer2023]

Ah thanks for the links to other discussions of the forum. It's interesting to learn more about it. I didn't realize there was a controversy surrounding calcium bufotenate lol. You seem knowledgable about the field of chemistry.

Still, the Yopo snuff is a very easy to prepare and administrate method for achieving substance induced altered states of consciousness. I look forward to working more with it in the future. I love a little spice in the nostril.

At low dose 100 mg. The yopo powder physiological effects are clammy palms, increased heart rate and light feathery body sensation a couple of minutes after insufflation into the nostrils using kuripe pipe.

As for the surian rue /reversable MAOI, it is strong stuff and taking a break from it for a couple of days atleast. I fell it is powerful chemical and dont want to cause brain damage for overuse lol.

At the moment I enjoy listening to icaros of the shipibo shamans of peru.

For those interested in Yopo I recommend starting on mapacho to get used to the snuff sensation.

 

[dragonrider]

You can also take it sublingually. I realy like it that way, because it is absolutely painless. Bufotenin is the main constituent of yopo, but it contains small quantities of 5-MeO-DMT as well, and that does seem to affect the whole yopo experience.

I've never taken it with mapacho, but i can imagine the two synergizing quite well.
From my own experience i can add that it also synergizes very well with shrooms, LSD and ayahuasca.

 

[Explorer2023]

I've never taken it with mapacho, but i can imagine the two synergizing quite well. From my own experience i can add that it also synergizes very well with shrooms, LSD and ayahuasca.

Well Mapacho being nicotine is so common place it synergizes well with most things.

Those MAOI's are strong and wouldn't want to have them everyday, not even regularly.

I dont think the surian rue/beta carbolines is necessary unless drinking tryptamines orally, although they do seem to potenciate the effects.

I can see the appeal for pure dmt molecule extractions, one whiff of pure substance and your off, without all the nausea and other draw back ect.

Personally I'm not into LSD and Shrooms or Ayahuasca for that matter, the long duration doesn't appeal to me. I like to be in and out.

 

[downwardsfromzero]

You can also take it sublingually. I realy like it that way, because it is absolutely painless. Bufotenin is the main constituent of yopo, but it contains small quantities of 5-MeO-DMT as well, and that does seem to affect the whole yopo experience.

I've never taken it with mapacho, but i can imagine the two synergizing quite well.
From my own experience i can add that it also synergizes very well with shrooms, LSD and ayahuasca.

Hey, got any good links for sublingual yopo preparations? Toast, grind, lime... yes? Have I missed anything?

 

[dragonrider]

You can also take it sublingually. I realy like it that way, because it is absolutely painless. Bufotenin is the main constituent of yopo, but it contains small quantities of 5-MeO-DMT as well, and that does seem to affect the whole yopo experience.

I've never taken it with mapacho, but i can imagine the two synergizing quite well.
From my own experience i can add that it also synergizes very well with shrooms, LSD and ayahuasca.

Hey, got any good links for sublingual yopo preparations? Toast, grind, lime... yes? Have I missed anything?

The preparation is the same as with the snuff. A 50/50% mixture of powdered seeds and lime, mixed with a little water. Then crushing when it's dried.

I have no links or sources. I just tried it and it worked.

Sublingually it is probably a little weaker by weight than when it's snorted, because why would people choose to hurt themselves, but a teaspoon is still quite effective.
But as i've said before, i usually do this in combination with some other psychedelics and then the effects are pretty spectacular. Very visual, but also with clearly noticable effects of 5-MeO-DMT. I realy like it.

The yopo i have was already powdered when i got it. So normally you would also need to toast, peal and grind the seeds first btw.

 

[Explorer2023]

Roast them very carefully on low to medium heat, dont want to burn them into charcole. Keep an eye on them, heat just enough to pop, then a little more after de-hulling to make them dry and crispy to grind in mortise and pestle.

I was wondering instead of 50/50 with seed and calcium hydroxide. Would it make sense to saturate demineralised water with calcium hydroxide and then just add a few drops of the liquid to the seed powder?

 

[Explorer2023]

Photo of Anadenanthera Peregrina plant sprouting after germination. I had little success with only 1 out of 6 germinating.

 

[Freebase69]

The preparation is the same as with the snuff. A 50/50% mixture of powdered seeds and lime, mixed with a little water. Then crushing when it's dried.

I have no links or sources. I just tried it and it worked.

I had an idea wondering if anyone has tried it.
My thoughts are adding the calcium hydroxide may unnecessarily bulks out the powder.

Would making a seperate solution of Calcium hydroxide and water, then adding the alkalized water only to the powder to make a paste work?
After all is not the purpose to just freebase the alkaloids.

So that after the excess water is evaporated, no extra non-active mass is added (usually 30 -50% more).
(Unless ofcourse you like snuffing calcium hydroxide/calcium carbonate).

I have some seeds and could try it.

And another thing, if only 5% by weight of seed is active alkaloids, why add 50% weight of base to freebase it. Would it not make more sense that only 5% of weight is needed?