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2-Br-LSD :: Non-hallucinogenic LSD analog with therapeutic potential

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CosmicLion

CosmicLion

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"New study suggests that a non-hallucinogenic LSD analog may hold therapeutic potential for mood disorders."

"Move over, Lucy in the sky with diamonds, there's a new non-hallucinogenic LSD in town. 2-Br-LSD is not your typical trip-inducing drug. Instead, it has a specific target in the brain, activating the 5-HT2A receptor but not the 5-HT2B receptor, unlike other psychedelic substances. Not only does it skip the intense hallucinogenic effects, but it also prevents tolerance from building up over time and it appears safer than it's hallucinogenic cousin"

"It boosts neuroplasticity, potentially providing hope for those suffering from depression. This non-hallucinogenic version appears to also help animals handle stress like a pro, reversing the negative effects of chronic stress"

psychedelicspotlight.com

Non-Hallucinogenic LSD Shows Promise for Treating Mood Disorders

A non-hallucinogenic LSD analogue may be able to treat mood disorders and chronic stress without the hallucinations.
psychedelicspotlight.com psychedelicspotlight.com
 
In my humble opinion, the development of this non-hallucinogenic LSD analogue may not really be desirable. To me, it feels like the pharmaceutical industry is trying to develop another medicine like the countless anti-depressants, sedatives... for mood disorders such as depression or anxiety.

A non-hallucinogenic LSD analogue as medicine feels more like a band-aid on the wound instead of actually healing the wound. I strongly think the trip is necessary to heal instead of a 'non-hallucinogenic band-aid' to keep us functioning in the rat race of society.

However, I must admit I support the research of these novel compounds as some people will surely benefit from it likewise the countless lives that are saved with antidepressants and others.
 
I think there are 2 other big reasons why pharma is going for non-hallucinogen psychedelics for neuroplasticity agents:

1. These will not end up as new research chemicals on the drug market, which already made David Nichols stop his research due to followed up fatalities just as an example :cry: :cry:

2. The bigger audience will more likely "accept" these drugs as a normal person is not into psychedelics and will probably even think they are just for weirdos and wasted junkies, expressed a little too harsh but my grandma would never take anything she knows is what people do to get high haha 😁 😁
 
Voidmatrix said:
I love how they assume that the visions don't add toward therapeutic value. Another example of these types of perspectives being overly reductive.

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Exactly. This has always puzzled me. I recently watched a documentary about Shulgin and they interviewed some researcher on non-hallucinogenic LSD-like molecules. He not only admitted, but prided himself on never having tried a psychedelic. That would explain it, then...
 
CosmicLion said:
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"New study suggests that a non-hallucinogenic LSD analog may hold therapeutic potential for mood disorders."

"Move over, Lucy in the sky with diamonds, there's a new non-hallucinogenic LSD in town. 2-Br-LSD is not your typical trip-inducing drug. Instead, it has a specific target in the brain, activating the 5-HT2A receptor but not the 5-HT2B receptor, unlike other psychedelic substances. Not only does it skip the intense hallucinogenic effects, but it also prevents tolerance from building up over time and it appears safer than it's hallucinogenic cousin"

"It boosts neuroplasticity, potentially providing hope for those suffering from depression. This non-hallucinogenic version appears to also help animals handle stress like a pro, reversing the negative effects of chronic stress"

psychedelicspotlight.com

Non-Hallucinogenic LSD Shows Promise for Treating Mood Disorders

A non-hallucinogenic LSD analogue may be able to treat mood disorders and chronic stress without the hallucinations.
psychedelicspotlight.com psychedelicspotlight.com
Click to expand...

Interesting! It could be advantageous as an 'afterglow aid supplement' to those who use LSD for its therapeutic psychedelic effects, especially if someone has an overwhelming and stressful trip and is looking to smooth out their on-going trauma therapy sessions.
 
Voidmatrix said:
I love how they assume that the visions don't add toward therapeutic value. Another example of these types of perspectives being overly reductive.

One love
Click to expand...
Let’s not fall into the trap of believing everyone should be like we are; not everyone would be able to handle a full-blown psychedelic experience, or the thought might just be too scary for some people to want to pursue.

People don’t need to be like us to want to heal, and neuroplasticity is incredibly important to healing old and tired ways of thinking.

I’m pro, this could be a more powerful game-changer than ketamine is.
 
risingupfromtheash said:
Let’s not fall into the trap of believing everyone should be like we are; not everyone would be able to handle a full-blown psychedelic experience, or the thought might just be too scary for some people to want to pursue.

People don’t need to be like us to want to heal, and neuroplasticity is incredibly important to healing old and tired ways of thinking.

I’m pro, this could be a more powerful game-changer than ketamine is.
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Hmm, interesting interpretation of what I said. Not a trap I'm falling into. Ive made similar considerations.
I'm very specific in what I'm referring to, which is the idea that the molecules themselves work all the healing magic and the experience is just secondary flotsam.

I don't need anyone to be like me or like us.

One love
 
Voidmatrix said:
Hmm, interesting interpretation of what I said. Not a trap I'm falling into. Ive made similar considerations.
I'm very specific in what I'm referring to, which is the idea that the molecules themselves work all the healing magic and the experience is just secondary flotsam.

I don't need anyone to be like me or like us.

One love
Click to expand...
ah well forgive me for my misinterpretation! it’s such a huge part of what fuels the culture war these days, i feel like i see it everywhere 🥴

but yeah, people wanna do what works best for them, and sometimes it’s not what’s best for us, obviously. the neuro-plasticity is what counts here and i applaud anyone that wants to get better or make changes in their life, regardless of how they wanna do it.

plus, having visions might be terrifying for some people, right? if this can help, sans that, then cheers 🤙
 
I understand. I'm very contextual and try hard not to over ascribe utility of things.

Definitely add more tools to the toolbox of improvement, but we shouldn't necessarily remove some out of a particular bias.

And yeah, I say all the time how psychedelics aren't for everyone. And it can certainly be hard dealing with visions, im sure some would just rather not.

One love
 
A drug like this administered chronically will cripple identity itself. We will become senseless, and dumb, unable to be touched by and act on that within. The goal is not to become cronically immune to stress. Stress provides so much focus, energy mobilization, and movement. The goal is not as much no-stress, as it is what type of stress. Also, our fears and ptsd’s are part of what make us human and help us craft a path forward. The agitational side of the HPA-Axis is something we should all treasure. There are things worth our fear, things worth our effort. A drug like this takes an axe to the divine creative way-finding spirit which resides in all of us. Only simple thinking drives such simple innovation. I hope this drug does not cause long term neuronal numbing the way protracted administration of antipsychotics and some SSRI’s has. We rely on sensitivity for everything, please don’t take it away.
 
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Transform said:
I'm just wondering what your chain of logic behind that assertion may have been. How might a psychoplastogen risk "crippl[ing] identity itself"?
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First things first, it’s probably going to be given as a CHRONIC CONSUMABLE. The chronic exposure will make the brain numb to elevated consciousness. It will make the brain numb to developing towards wholism and integration. Natural Genius which lives in the fine details of your mind & soul will be stifled, muted blunted. This is how people will have their ‘psychoses’ alleviated. The very purpose of this invention is to fraction identity. People will not get feeling from distant places as easily. They will literally exist in a smaller psychic universe. Perhaps there are some ways to engage with this drug in a wholesome way, but the dose makes the poison here, and chronic administration will handicap (for a time) the souls of our youth who get fed this. The philosophy behind it’s design is short sighted and not wholistic in the slightest, and the neurobiology of how it acts with our minds ~ under chronic exposure ~ is not healthy.

There is much more to say as always.

Your mood is disorderly, and that’s beautiful. Wake up to your true NATURE people, you are not a cube. Your feelings are literally, wild 🌌
 
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