4-AcO-MET + oral harmalas ?

[The Sofa Traveler]

Hi Nexians ! Has anyone tried this combo yet? If so, what's your opinion, tips & tricks ?

 

[Varallo]

[NEW SUBFORA] 'Nootropics' and 'Novel Psychoactive Substances (RC)' - Announcements and Suggestions - Welcome to the DMT-Nexus

Just so you know, on the combo I have not tried it yet, but it’s something that in my head would be very promising, the AcO met and HO version, are to me, rather boring compounds but adding some harmalas might make them more interesting.

 

[The Sofa Traveler]

I'm still looking for any first hand experience feedback with this specific combo. I know most of tryptamines are safe with harmalas but there are also some exceptions and I'd prefer to check combo safety above all. So, if you have experienced 4-AcO-MET with harmalas, let me know.
Peace.

 

[Transform]

I'm still looking for any first hand experience feedback with this specific combo. I know most of tryptamines are safe with harmalas but there are also some exceptions and I'd prefer to check combo safety above all. So, if you have experienced 4-AcO-MET with harmalas, let me know.
Peace.

So let's get this straight - you're wanting someone else to be the guinea pig

You could always try following the Shulgin protocol - take a tenth of the tiniest dose and work your way up from there. Your prior experience with harmalas should be able to guide you on that side of the equation, but it would take a good scour of the literature to find receptor and metabolic data for 4-AcO-MET, if any even exists.

Where else have you looked for relevant info?

 

[The Sofa Traveler]

So let's get this straight - you're wanting someone else to be the guinea pig

No, I don't want someone else to be the guinea pig, I ask if someone already tried. Anyway, from what I've found so far on this combo, that is to say : nothing, I'm probably going to be the guinea pig My main concern is about pharmacology of the 4-Aco-MET, I wonder if it could be a SSRI, like 5-MeO-DMT.

 

[Varallo]

Ask Grok.

Recommendation

Without more user reports or research, it’s challenging to confirm the safety of this combination beyond general tryptamine-MAOI compatibility. If you proceed, prioritize harm reduction, start with low doses, and consider joining forums like DMT-Nexus or Shroomery to share your experience and gather more feedback from the community. If you have access to a lab or testing service, verifying the purity of both substances is crucial.



If you’d like, I can search for additional user reports or provide more details on related compounds (e.g., 4-AcO-DMT or 4-HO-MET with harmalas). Let me know! Peace.

Hahaha, I did and it literally recommended to join the Nexus and ask here silly robot.

 

[Transform]

If you proceed, prioritize harm reduction, start with low doses, and consider joining forums like DMT-Nexus

Makes one feel almost vindicated

 

[The Sofa Traveler]

Ask Grok.

Thanks but I wouldn't rely on a chatbot for harm reduction purpose. I'm asking if someone has actually tried the combo or if someone has a paper or study to share about the 4-AcO-MET pharmacology. Anyway, given how things are going, it seems I'll probably be a pioneer the guinea pig. Because yeah, I'm gonna try it, unless I find some solid contraindications. Until then I will continue my research.

 

[Transform]

The chatbots might be able to summarise pharmacological data and references (if any exists, of course) but it would be imperative to check those references oneself.

There's a link to "Psychedelics and the Human Receptorome" in the resources section, iirc. Maybe you'll be able to make some inferences from the data available there.

 

[ShadedSelf]

Ive taken harmalas with 4-HO-MET, Im still here, no idea about AcO.

 

[The Sofa Traveler]

Ive taken harmalas with 4-HO-MET, Im still here, no idea about AcO.

Nice ! If we assume the 4-AcO is metabolized to 4-HO, I'm interested in your testimony. Did you also try the 4-HO-MET without harmalas ? If yes, how would you compare the experience with and without harmalas ? Should I expect same potentiation as with psiloc(yb)in (psilohuasca) ? Do you remember the amount of both 4-HO-MET and harmalas you took ?

 

[ShadedSelf]

I dont think Ive ever taken it without, I cant really compare, for me its more about the gentleness that harmalas usually bring anyways.
Ive taken doses of ~5mg with around 100mg of harmalas. Im quite sensitive but its still a light dose.

 

[Transform]

Makes me wonder if such an experiment would help highlight any differences between the two compounds. The 4-AcO may have intrinsic activity of its own (as suggested by some wrt 4-AcO-DMT), and/or there may be a difference in bioavailability, for example.

 

[The Sofa Traveler]

Hi there, scoop : I tried the combo Here is a quick trip report, I post it here so people looking for information about the combo can also read the previous insights from this thread.

Saturday evening. After a period seeking information about this uncommon combo we finally tried it. It happened at home with 2 friends of mine, both had previous experiences with psilohuasca, harmalas and DMT, and other psychedelics.
Everybody was in a good mindset, impatient to try this 4-AcO-MET (metacetin)+harmalas combo. I already had a few previous experiences with the metacetin alone (without harmalas).
We settled outdoor, it was a warm night. Deckchairs under the chestnut tree, some lights directed towards the surrounding trees. An amplified speaker on stand was playing various chill music. Comfortable cocoon.

10 PM : we decide to take 280mg refined freebase harmalas extracts (extracted following HarmallamaTek) dissolved in lemon juice, we drank it adding a few water then we took 20mg 4-AcO-MET about 1 hour later. We had all three been fasting for at least 3 hours.
Harmalas slowly started onset 30 minutes after absorption but we decided to wait a little bit more before taking the 4-AcO-MET. The metacetin effects were quite slow to set up , longer than with mushrooms, and peak was probably reached like 1 hour later. The overall onset of both metacetin and harmalas was incredibily smooth, zero nausea, almost no bodyload, very clean and clear, no mind confusion. Same feeling for all of us.
Trip lasted about 5/6 hours, most of the time we were screwed on the deckchair, as if gravity had doubled, alternating times of interaction and communication, intense laughs and individual introspection. Definitely very sedative, not something you would take on a festival or party.
Sound perception was incredible, music was fully immersive. I had the most beautiful CEV ever seen on psychedelics, DMT excepted. Continuous 3D self transforming kinetics with very colored details, reminiscent of those we can have with DMT.

4.30 AM : the effects of the 4-AcO-DMT appear to have mostly dissipated. The sky on the eastern side begins to clear up, the day was about to break. We put a large blanket on the grass and decided to rest and sleep, smoalking joints under the clear sky, enjoying the remaining harmalas vibe.

Conclusion : harmalas potentiation was quite effective. Compared to the previous times I had 20mg metacetin without harmalas, the feeling was ways more intense and stuff lasted like 1 or 2h longer. Definitely brought some warmth and depth to this molecule reputed to be 'cold' if not somewhat boring. 20mg 4-AcO-MET seems the perfect dose with harmalas. Strong enough but still manageable. Metahuasca, lets call it like that, is IMO definitely worth it.
Peace.

 

[pantostao]

I've also tried 4-HO-MET with syrian rue tea, but no 4-ACO-MET, or with freebase harmalas, just the crude tea.

My doses were quite small on the tryptamine side. It's been a while, but I'd say it was around 10mg of 4-HO-MET, + tea from ~ 4g of syrian rue seeds.

The experience was really really calming, as if everybody in the whole world relaxed at the same time. My friend and I were able to take a walk to a nearby river, and felt awesome, incredibly relaxed, everybody we saw felt just as relaxed as we were. The tryptamine dose was light but definitely noticeable, and probably was potenciated somewhat by the syrian rue tea. But the most noticeable effect from the combination was the incredibly relaxed feeling we both got, and, as you put it, "as if gravity had doubled". We didn't get a full blown psychedelic experience, it was more of a museum dose.

All in all, it was a nice experience, and we thought we should try again sometime. It lasted for around 8 hours, which was a bit longer than I expected 4-HO-MET alone

____


I also tried to vaporize 15mg of 4-HO-MET with ¿15? mg of freebase harmalas a few years ago, and it was a very nice experience as well. At that point, I didn't feel like the vaporized harmalas had a big impact on the tryptamine experience. I first vaporized the harmalas in a e-mesh rig, and the 4-HO-MET inmediatly afterwards.

The 4-HO-MET hit like a truck just a few seconds after inhaling. 2-5 minutes later I was having a pretty deep experience that felt pretty chaotic and intense. I don't think I got enough harmalas in my system to modulate the 4-HO-MET experience, or maybe I should have waited longer after dosing those. The visuals got pretty intense as well.

I ended that experience by vaporizing some DMT too, so I'm not sure about the total duration. But it was short, I was coming down from the 4-HO-MET around 1 to 1.5 hours after smoking it.

 

[Transform]

Thanks for the reports, both of you. Very interesting!

One point of contention, @The Sofa Traveler - use of the term "azo" here, as in "azomet" and "azohuasca", could be seen as misleading from a chemical point of view. The prefix "azo" is already in use to denote compounds containing a R-N=N-R' group, e.g. R = R' = Ph is azobenzene, and there's a whole enormous group of azo dyes based on this (having played an overarching role in the birth of the modern dyestuffs industry).

There's also the term "aza" meaning "nitrogen where there would have been a carbon". Both of these terms are derived from the French "azote" (nitrogen).

While fully understanding the desire for a mellifluous name here, I'd discourage wider propagation of those particular acronyms for the aforementioned reasons

 

[The Sofa Traveler]

I'd discourage wider propagation of your personal acronyms for the aforementioned reasons

Right, sorry for that, just to mention I didn't invent the 'azomet' term, it's not a personnal acronym, it's one often seen for the 4-AcO-MET, alongside the alternative term 'metacetin'. It's like other RC's terms, from the like of 'miprocin" for 4-HO-MiPT or 'psilacetin' for the 4-AcO-DMT, etc. Maybe i should replace it with 'metacetin' in my TR, which could be less ambiguous. Initially, I just used the term to avoid using repeatedly '4-AcO-MET', for a smoother reading.

 

[Transform]

Right, sorry for that, just to mention I didn't invent the 'azomet' term, it's not a personnal acronym, it's one often seen for the 4-AcO-MET, alongside the alternative term 'metacetin'. It's like other RC's terms, from the like of 'miprocin" for 4-HO-MiPT or 'psilacetin' for the 4-AcO-DMT, etc. Maybe i should replace it with 'metacetin' in my TR, which could be less ambiguous. Initially, I just used the term to avoid using repeatedly '4-AcO-MET', for a smoother reading.

Understood, I should have guessed that popular culture would already have come up with such semantic mangling, as my objection is wholly arcane outside the field of chemistry. Edited my posted in acknowledgement of this.

It's beyond me why anyone would dare to take an interest in drugs without understanding at least some chemistry but there we go

Moving on from that, the way you described the sensation of "the whole world having relaxed" came across as very appealing to me.

 

[The Sofa Traveler]

Understood, I should have guessed that popular culture would already have come up with such semantic mangling, as my objection is wholly arcane outside the field of chemistry. Edited my posted in acknowledgement of this.

Yes, and I understand your point too, that's why I removed the 'azomet' term, replaced with 'metacetin'. As a French, I can understand the ambiguity with 'azote'.

 

[The Sofa Traveler]

Moving on from that, the way you described the sensation of "the whole world having relaxed" came across as very appealing to me.

@pantostao was the one using the "whole world having relaxed " metaphor, I was rather talking of "doubled gravity" feeling but one in the other we were describing the same reality of the experience : something very sedative and relaxing. This sedative/relaxing feeling was definitely stronger with the harmalas, which brought their own part of sedation to the combo. Without harmalass, the 4-AcO-MET is only lightly sedating, like shrooms or even less.