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4-AcO-MET

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Psilociraptor

Rising Star
I'm surprised to not see this one mentioned much. This is hands down the best of the typical classic/research chemical psychedelics I've tried (ie excluding DMT/ayahuasca/5-meo-xxx). Recently had the pleasure of taking 50mg of this one. It was extraordinarily gentle yet not at the expense of it's depth. The visuals were very pronounced. Like watching golden spinning fractal clocks all over the place. The trip was extremely optimistic and upbeat. I was laughing hysterically in ways I've not experienced since my honeymoon with psychedelics. I felt like i was basking in rays of golden sunshine. The entheogenic qualities of this substance were also striking. Many have called it recreational and spiritually dull. Now granted 50mg is quite a higher dose than most recommend, but i was getting my butt kicked (gently) all over the place. It was every bit as humbling as an entheogen should be and took me back to a very primal place. I spent much of my night on the floor with my animals sharing my carrots off the same "plate" imagining myself in a world where we shared the same status. No master, no follower. Just two beings who's niches intersected at the desire for companionship and group security.

To top it off, no real body load to speak of. Very pleasant, even physically euphoric and possibly entactogenic at times. I should also state that as any proper entheogen this one did have the potential to go sour and I did experience some moments of confusion and dark vibes. But overall the trip felt relatively lucid, easy going, and less manic than the other tryptamines I've experienced.
 
Not sure why I never looked into this further, but I'll definitely be looking into this in the short-term future after some casual research online.
 
I have no experiance with 4-aco-MET, but I do have experiance with 4-ho-MET.

I'm guessing that the acetoxy grouping at position 4 is metabolized into a hydroxy group in vivo, making 4-aco-MET a pro-drug for 4-ho-met...Though 4-aco-met may be active before it's metabolized...

4-ho-MET is amazing, the experiance is very similar to psilocin, it's what you would expect from a four hydroxy N alkylated tryptamine, all of which remind me of psilocin experientially in one way or another, specially in the way of visual experiance and transcendental, philosophical, and Entheogenic psychological experiance...


-eg
 
So no more information here?

Just like 4-aco-DMT is a prodrug of 4-ho-DMT, I'm willing to bet the 4-aco-met is a prodrug for 4-ho-met...

anytime you want a prodrug of a tryptamine with an hydroxy group at position 4, you can just substitute the hydroxy grouping with an acetoxy grouping, the acetoxy grouping will become a hydroxy grouping in vivo...at least this seems to be the case.

Even with 1-acetyl-LSD this seems to be the case, minus the oxygen because you want an NH grouping at position 1, so the acetyl grouping connected to the nitrogen of the pyrrole ring Returns to a hydrogen atom, restoring the NH grouping of the pyrrole ring, giving LSD in vivo.

With 1-propionyl-LSD, just as above, only using a propionyl grouping at position one of LSD, the propionyl grouping becomes the needed hydrogen atom in vivo to form the NH grouping of the pyrrole ring, giving LSD...


I wonder if 4-propionyloxy-DMT would become 4-ho-DMT in vivo...

These kinds of chemical tinkering fascinate me...

-eg
 
I really don't doubt it's a prodrug. On the contrary I don't find the acetylation/propionylation very exciting. I grabbed the acetoxy because it was available and considered more shelf stable. Any in vivo differences would be the result of slightly altered kinetics and it doesn't seem to provide much difference. Mainly just useful for skirting drug laws. No further information on my end as I have not taken it since, but my gf has and I've given it to several friends who absolutely loved it and said it was exceptionally clean feeling. I certainly look forward to the next trial and encourage anyone who's considering it to give it a go. Still my favorite substance to date.
 
A pro-drug is a compound which is without activity, but is then metabolized into an active product in vivo.

So, what is the term if the compound starts out as being active, and is also metabolized into an active compound?

Is it still considered a pro-drug?


I still wonder if 4-propionyloxy-DMT would become 4-ho-DMT in vivo...


-eg
 
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