69rons Mescaline Extraction TEK - Problems with Purification with MEK

[curious1]

"Purification of Mescaline Acetate

To clean mescaline acetate, dissolve 200 mg of impure sticky amber mescaline acetate in 2 ml of cold MEK. Smash the pure mescaline finely in the MEK. You want the mescaline acetate to form a fine powder at the bottom. Wait for a while until the mescaline acetate powder sinks to the bottom and simply decant the MEK slowly, being careful not to disturb the mescaline acetate. After one cleaning, the mescaline acetate will still be somewhat amber or tan in color. Repeat with 2 ml more cold MEK. After a second wash and decant, dry the mescaline acetate with a fan. After all the smell of the MEK is gone, you're left with off-white nearly pure mescaline acetate.


Pure mescaline acetate is a white free flowing powder with a slightly waxy texture very similar to freebase DMT. You'll find that it's much easier to manage after purifying it, being not nearly as waxy, and no longer sticky."


I found 69rons dry mescaline acetate extraction TEK about a month ago. I got hold of some d-Limonene, vinegar and slaked lime. I then found some live San Pedro cut off the peel and dried it.

I followed 69rons TEK with exactly the right quantitys of ingredients as well as I could with the equipment I had. Although it was messy everything went as I thought it should. Finally I had a light brown crude sticky gum that was evaporated without heat [fan only] from the vinegar.

This gum was then put into MEK that had been in the freezer and 'smashed'...Strangely I found that the brown sticky gum did not elicit mescaline acetate as expected. The MEK I poured off was quite dark..what was left behind remained a slightly less brown gum of a slightly more viscous nature..

Any help on what the problem might potentially have been would be appreciated.....

 

[modern]

This is misleadingly inaccurate. Primary amines like mescaline do not form N-oxides (but they can get oxidised, which is not the same thing). N-oxide formation is restricted to tertiary amines like trichocerine or DMT, and compounds with three nominal bonds from carbon to nitrogen, such as pyridines, isoqinolines and nitriles. Any of these may also oxidise in ways which do not involve N-oxide formation!

Just in case anyone was wondering…

If I were to place mescaline hcl into a 30-50% h2o2 solution would that form mescaline oxide or would it need to be freebase? Or nothing happens?

 

[Transform]

If I were to place mescaline hcl into a 30-50% h2o2 solution would that form mescaline oxide or would it need to be freebase? Or nothing happens?

Good question. Here's a text which explains the likely outcome, and more:

23.11: Oxidation of Amines

Nitrogen has a wide range of oxidation states in organic compounds.

chem.libretexts.org

Remember, mescaline is a primary amine.

 

[modern]

Good question. Here's a text which explains the likely outcome, and more:

23.11: Oxidation of Amines

Nitrogen has a wide range of oxidation states in organic compounds.

chem.libretexts.org

Remember, mescaline is a primary amine.

Most went over my head but I'll try reading again.

 

[Transform]

Most went over my head but I'll try reading again.

Non-aromatic* primary amines oxidise in the sequence: (alkyl)hydroxylamine (R-NHOH) - nitroso compound (R-NO) - nitro compound (R-NO₂), where R is one of many organic groups, and in this instance with a fully saturated carbon attached to the nitrogen.
[*Mescaline has an aromatic - substituted benzene - ring in its structure, but it is not attached directly to the nitrogen.]

Because of the reactivity of some of the intermediate stages of the oxidation, particularly the nitroso group, along with the aromatic portion of the molecule, depending on the reaction conditions, there will likely be a number of side reactions such as cyclisation to an indole derivative, oxidation at the benzene ring to form a quinone and/or crosslinking to form a horrible tarry mess. And that's all without mentioning the possibility of diazotisation and its consequences.

It's quite normal for this to go over most people's heads