TiHKAL entry #48: a-MT
"…thirteen AMT analogs were investigated for their potential to inhibit MAO. An in vitro assay analyzed using hydrophilic interaction liquid chromatography-high resolution-tandem mass spectrometry was developed and validated. The AMT analogs were incubated with recombinant human MAO-A or B and kynuramine, a non-selective MAO substrate to determine the IC50 values. The known MAO-A inhibitors 5-(2-aminopropyl)indole (5-IT), harmine, harmaline, yohimbine, and the MAO-B inhibitor selegiline were tested for comparison. AMT and all analogs showed MAO-A inhibition properties with IC50 values between 0.049 and 166μM, whereas four analogs inhibited also MAO-B with IC50 values between 82 and 376μM. 7-Me-AMT provided the lowest IC50 value against MAO-A comparable to harmine and harmaline and was identified as a competitive MAO-A inhibitor."
In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks. Wagmann, L., Brandt, S. D., Kavanagh, P. V., Maurer, H. H., & Meyer, M. R. 2017. Toxicology letters, 272, 84–93. doi: 10.1016/j.toxlet.2017.03.007
"As for antidrpressant psychedelics, AMT is really your best bet, it was actually approved for use as an antidepressant and was in use as such for a time until too many people reported that it made them feel weird, and they discontinued it. It's a very nice recreational drug, it feels at least as much like a rolling drug as it does a tripping drug. It is different from any other psychedelic because it is a triple monoamine releaser, as well as a serotonin agonist. However, if used infrequently, even in high doses, it doesn't have a comedown or crash or a depleted feeling for me... rather it gives me a long-lasting antidepressant glow. And if used in low doses (5-15mg) it can be used daily or near-daily without depletion. I believe it was prescribed at 5 or 10mg for daily use. As a recreational drug, I like it most around 60mg (of the succinate or fumarate salts, which is all that's made now, as far as I know, as it is much more stable that way)." (Xorkoth, bluelight.org, 2022-08-31, private message)
"…thirteen AMT analogs were investigated for their potential to inhibit MAO. An in vitro assay analyzed using hydrophilic interaction liquid chromatography-high resolution-tandem mass spectrometry was developed and validated. The AMT analogs were incubated with recombinant human MAO-A or B and kynuramine, a non-selective MAO substrate to determine the IC50 values. The known MAO-A inhibitors 5-(2-aminopropyl)indole (5-IT), harmine, harmaline, yohimbine, and the MAO-B inhibitor selegiline were tested for comparison. AMT and all analogs showed MAO-A inhibition properties with IC50 values between 0.049 and 166μM, whereas four analogs inhibited also MAO-B with IC50 values between 82 and 376μM. 7-Me-AMT provided the lowest IC50 value against MAO-A comparable to harmine and harmaline and was identified as a competitive MAO-A inhibitor."
In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks. Wagmann, L., Brandt, S. D., Kavanagh, P. V., Maurer, H. H., & Meyer, M. R. 2017. Toxicology letters, 272, 84–93. doi: 10.1016/j.toxlet.2017.03.007
"As for antidrpressant psychedelics, AMT is really your best bet, it was actually approved for use as an antidepressant and was in use as such for a time until too many people reported that it made them feel weird, and they discontinued it. It's a very nice recreational drug, it feels at least as much like a rolling drug as it does a tripping drug. It is different from any other psychedelic because it is a triple monoamine releaser, as well as a serotonin agonist. However, if used infrequently, even in high doses, it doesn't have a comedown or crash or a depleted feeling for me... rather it gives me a long-lasting antidepressant glow. And if used in low doses (5-15mg) it can be used daily or near-daily without depletion. I believe it was prescribed at 5 or 10mg for daily use. As a recreational drug, I like it most around 60mg (of the succinate or fumarate salts, which is all that's made now, as far as I know, as it is much more stable that way)." (Xorkoth, bluelight.org, 2022-08-31, private message)
