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alruin (Mandragora officinarum), datura extraction

Migrated topic.

panoramix

Rising Star
hola nexus

i whas wondering if it whas possble to extarct alks from alruin or datura.

if some knows how or has a mindstorm howto please post some info.

greets pano
 
hola

first thenkx for the reply.
i whandet to extract he alks becous they are so degares.
and what is the effects from 3 seeds i i might ask/


greets pano
 
you really should not concentrate alkaloids you are not familiar with

These types of plants are not psychedelic they are dementia inducing

Meaning you will not know your ass from your mother


THEY CAN BE FATAL

Best not to take up this project

your inexperience and pardon me if i say your ignorance is very frightening

and makes me hope to god that you have only humble intentions

Take care and remember knowledge is power
 
okay, once again an innocent, maybe slightly inexperienced person's thread on tropane alkaloids has been bashed with short non-informational posts that disgrace the ideas of this forum.

Mandrake, Datura (all varieties), Benedryl and Gravol all contain tropane alkaloids that are psychoactive.

Mandrake is particularly dangerous because it is very hard to tell the potency of the herb.

While the big "Hallucinations, elaborate interactions with hallucinations" can temp lots of people (SWIM too)

When taking a look at the whole picture, the benefits are FAR FAR outweighed by the risks

The effects are:
hallucinations, elaborate interaction with hallucinations
loss of appetite, thirst
loss of sense of the passage of time
dizziness, headache
dry mouth, dry eyes
inability to focus eyes (can persist for multiple days)
feeling of weakness
sedation, stupor
uncoordinated movement
fear, anxiety, panic
confusion, delirium, impaired cognitive function (sometimes leading to extremely dangerous behavior)
amnesia
blockade of sweat glands, impairing heat dispersal
difficulty breathing
cardiac failure possible at large doses

Now even reading this SWIM was still interested, he had never had interactions with hallucinations and only ever had 1 hallucination ever (on mimosa + rue brew)

When SWIM started his regular working up slowly from a very small dose to be safe he was noticing a few things:
1: He has a large tolerance to them
2: The effects are far from "fun"
3: The more he took the worse he felt.

While SWIM has worked with datura for months taking over a dozen test doses he has NEVER had a hallucination and he has NEVER gotten anywhere near euphoria from it.

SWIM quit taking it last month because the effects were so lame and made him feel terrible for not only the next day but up to 36 hours after.


That being said datura has several uses in non-psychedelic (at least alone) doses.

5-10 datura seeds can be combined with Morning glory/HBWR, Mescaline/Cactus, Passionflower, Bufotenine and Ayahuasca/Pharmahuasca to reduce nausea and increase the effects felt from either alone.

Datura stramonium and inoxia are the most common, being slightly stimulating and slightly sedating respectively.


If you are REALLY interested in pursuing this still then I recommend you read this thread fully.
 
Most of these alkaloids are active with much less than 1mg. This is why extractions are often not necessary. Concentrating tropane alkaloids would be risky. It be like playing with other low-dose drugs like lsd, fentanyl, bromo-dragonfly, etc. Not a very good metaphor, but I hope you get what I'm saying. Now, it's not necessarily fatal to extract these tropane alkaloids, but please realize the gravity of what you are doing. You could really hurt others and not just yourself when consuming and/or extracting these alkaloids.

For example, hyoscyamine is often given in doses of 0.125mg, thus extracting and concentrating the hyoscyamine content of any plant is risky.
Adults and children 12 years and older should not take more than 1.5 milligrams in 24 hours. Children aged 2 to 12 years should not take more than 0.75 milligrams in 24 hours.
Levsin (Hyoscyamine): Side Effects, Uses, Dosage, Interactions, Warnings

If one were looking to make a poison, one might look into this type of extraction. The death from consuming datura/mandrake would indeed be horrifying.:shock: This is what most people are trying to warn you about.
 
SWIM reckons that the recipe for pure Scopolamine should be out there, despite the risks.

Without access to pure Scopolamine, ignorant, wreckless people will still ingest Solanaceous plants.
The problem with that is that one never knows how much miligrams of Scopolamine/Atropine one is ingesting.

SWIM reckons that for harm reduction surrounding the use of Scopolamine/Solanaceous plants it's best if detailed effective/lethal dosage and extraction information was more available. Wreckless, ignorant people would at least have the option to dose very carefully and precicely.

That seems better to SWIM that just fearfully hushing the subject up, advising against it and waiting untill the next unlucky fool seriously harms him/herself by drinking Brugmansia tea.
 
LawnBoy said:
Most of these alkaloids are active with much less than 1mg. This is why extractions are often not necessary. Concentrating tropane alkaloids would be risky. It be like playing with other low-dose drugs like lsd, fentanyl, bromo-dragonfly, etc. Not a very good metaphor, but I hope you get what I'm saying. Now, it's not necessarily fatal to extract these tropane alkaloids, but please realize the gravity of what you are doing. You could really hurt others and not just yourself when consuming and/or extracting these alkaloids.

For example, hyoscyamine is often given in doses of 0.125mg, thus extracting and concentrating the hyoscyamine content of any plant is risky.
Adults and children 12 years and older should not take more than 1.5 milligrams in 24 hours. Children aged 2 to 12 years should not take more than 0.75 milligrams in 24 hours.
Levsin (Hyoscyamine): Side Effects, Uses, Dosage, Interactions, Warnings

If one were looking to make a poison, one might look into this type of extraction. The death from consuming datura/mandrake would indeed be horrifying.:shock: This is what most people are trying to warn you about.

I’d have to say, as someone who knows how to perform scopolamine and hyoscyamine extraction, and isolation, that it is EXTREMELY RISKY. You should not do it. It’s more risky than extracting strychnine. With strychnine, a lethal dose is many times higher than a lethal dose of scopolamine or hyoscyamine, and it doesn’t soak into your skin that well. Scopolamine soaks into your skin very easily. Just by handling it you could get a very serious dose of it. With something like a strychnine overdose, you have the chance of calling for help before you die. With a scopolamine overdose, you’ll be so far gone mentally that calling for help will be almost impossible. I’ve read that as little at 10 mg of scopolamine can be lethal. The dose quoted for strychnine is usually about 50 mg, some say 30 mg, some say 120 mg. Scopolamine is clearly more toxic.

Strychnine, LSD, scopolamine, hyoscyamine, and other drugs that are active in microgram ranges are extremely dangerous to work with.

The best way to deal with scopolamine is to make a large concentrated mother tincture of Datura inoxia seeds, say 10 gallons or so, using a large batch of plant material. Then have 1 ml of that tested for scopolamine content. The 10 gallons of tincture will be uniform in potency, so if you know how potent 1 ml is, then you know how potent every 1 ml of that 10 gallons will be. This is how standardize tinctures are made. A small batch of the concentrated mother tincture is tested, and then diluted to assure a specific dosage of the target alkaloid is present per milliliter in the end product.

It’s not illegal to test for scopolamine, at least not in the USA.

Having a standardized tincture of Datura inoxia where 1 ml contains 100 mcg of scopolamine would be pretty cool I think. That woiuld be very useful as a sleep aid. It takes over 1000 mcg to cause mental effects and about 10,000 mcg to be lethal, so a 1 ml dropper full would be very far from a dangerous dose. At that potency you'd need 10 droppers full for mental effects, and about 100 droppers full to approach a lethal dose.
 
Sorry I accidentally put the doses in mg instead of mcg in my above post. It was a typo. I have since fixed it.
 
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