I just had to jump in on this. I've been wanting to start a whole new thread, inviting all the colonic crusaders to start dropping their knowledge, but this seems a good a place as any. Often people get weirded out, as if no-one poops, but I'm good to answer any question as far as I know it. And by any, I do mean any. I wish there was more up-front discussion of this because of how useful it is. I've done rectal MOAI + vaped spice maybe 20 times? Enough to know my way around behind the scenes, if you know what I mean.
And you do.
the reason why rectal administration is stronger is that most of the dose goes directly to the bloodstream without passing through the liver, does it get effectively redistributed again to the whole body including the stomach? i don't think so, rectal harmalas + vaped DMT would work quite well i think.
This is my favorite method, plugged inhibitor and vaped DMT. I don't think plugged MAOIs and oral DMT would work, based on solid reasoning of the gut not being inhibited, and maybe the DMT never making it into the blood stream, but I have not heard of one person actually try it.
CALLOUT: If you've ever seen a trip report of an anal MOAI + oral spice, oral MOAI + anal spice, I'd love to see it.
Anyway, as for the MOAI being stronger, I'm not sure I would call it that per se. It's more forceful, but in a slow way, than sublingual. It crescendos, blossoms. Oral MOAI is waiting game then a gut punch, followed by an almost non-consensual opening of the portal - if I wasn't in the zone I'd hurt. This is at least how I experienced them.
Some here claim that Harmalas are responsible for the nausea from Aya/pharmahuasca.
I think the truth is that many alks/psychedelics can cause nausea, and certainly eating harmalas does create stomach pains for me. I think that even if the MOAI didn't do it when consumed orally, the DMT might anyway -if taken orally. When I've plugged the MOAI (sometimes dissolved in juice, other times in water), I've never had any nausea. It's darn near perfect ... in its own way. But if you struggle with tummy pains, plug the MAOI. It's almost like a cheat code. But the trip is affected by the ROA - it pulses, goes in waves, not unlike oral MOAI, and for me the trip was much more intra-cosmic inside my body (maybe because the colon/prostate has sensory feeling of sorts, and bloodflow variations can be felt, unlike my stomach lining, which I tend not to feel at all) then externally multi-verse cosmos.
I've found that like sublingual, there is some immediate absorption, and it'll augment a DMT trip if you let it sit in the chamber for 5 minutes, but if you have a clean bowel, you'll get better absorption at 20 mins.
But even weirder, the "harmalization" affects may linger for a long time - like an hour or more. I've found that out the hard way - I did like 30mg plugged harmaline acetate then vaped 40ish mg DMT 30 mins later. (You can tell the harmalas are starting to work by a sort of flush throbbing pulse in the anus - a little like a "whhaaa whaaa wwwhaaa" speaker noise, but in your butt. It's mild-ish)
So anyway, the first trip way good, but I thought I kind of missed my mark, maybe didn't time it right, only had 10 mins of hyperspace, nothing deep. I play around on my PC for 20 mins, enjoying the moderate afterglow and thoughtspace.
Then I decide to clean off the screens, not wanting to waste the little that might still be there.
BOOOOOOOOOOOOOOM. The heavy darkness of being folded into a new cosmos held entirely inside my own butthole began. Reality's edges burned out like a short match and I fell deep into the abyss.
That harmala effect was still there, and the little bit of DMT - couldn't have been more than 15-20 mg's - hit with a hammers force upon my consciousness.
