• Members of the previous forum can retrieve their temporary password here, (login and check your PM).

April 22 SHE for mescaline

Dual purpose post

Shameless Bump

+

Addressing an actual ?

NotTwo said:
Anyone fill me in on how one of these SHE events works?
Click to expand...
Quite so, you may find this somewhat informative re: how all this came to be and wut it's all about.

Some notes concerning that: It was collectively determined by those participating in that original SHE that sending a glyph into hyperspace or meeting at a designated location isn't really feasible. Hyperspace just doesn't work that way, and that certainly was not for lack of trying to make spurious connections, bless their little hyperhearts.

The first official SHE was officially a failure, but the idea of mass group psychedelic experiences creating powerful ripple effects across the collective consciousness still holds merit and the research is ongoing. :thumb_up:
 
dreamer042 said:
@ EG I'm not sure that harmalas actively potentiate mescaline the way they do with tryptamines, it seems just like moar of a nice synergy ime. In any case, it's lovely and I say go for it. :thumb_up:

To all those who don't have cacti's ready for processing, you can still join the SHE with another medicine. We'll be going for a long, long time, so hop on in with some blotters or mushies or even that old changer pipe. Don't be scurred. 😁
Click to expand...

As 3,4,5-dimethoxy-phenethylamine (mescaline) is a mono amine, mono amine oxidase inhibitors would be effective in preventing MAO from destroying the compound...

Shulgin/TIHKAL states:

WITH MESCALINE

(with 100 mg harmaline, 60 mg mescaline (3,4,5-trimethoxyphenethylamine) [20 min]) "At two hours I was in a pleasant state of physical relaxation, a fine sense of well being, and I found music most enjoyable. From then to the fourth hour, thoughts flowed freely, and it became obvious that insight was a major part of this experience. Normally unconscious thoughts were easily available. It was as if I could observe my mind in operation, as facts were weighed to form conclusions. By the sixth hour music was a thing of beauty, with the higher notes crisp and clear. The harmaline has probably worn off. Sleep at eight hours, and the next day was without any adverse effects. This was a remarkable experience, the insight of TMA, and the relaxation of MDMA."

(with 150 mg harmaline, 100 mg mescaline [15 min]) "A stomach ache developed at about 45 minutes, followed by a mild nausea which occurred intermittently throughout the next six hours. I felt comfortable, although there was a slight discoordination at about two hours. Walking was never a problem but did require more concentration than normal. Colors on the television were obviously more intense, and highly saturated at this point and moderate photophobia developed. Even a fire in the fireplace was distracting, and stereo was best enjoyed in the dark. Attempts at sleep did not work until the ninth hour. Upon awakening there was a feeling of dehydration but otherwise no ill effects. Mild looseness of stools was present later that morning. Since experiments using only mescaline at doses between 80 and 120 mg resulted in no CNS effects at all, it seems clear that the MAO blocking effects of the harmaline were crucial to this experience.

Erowid Online Books : "TIHKAL" - #13 HARMALINE

Entry #13 HARMALINE from TiHKAL by Alexander & Ann Shulgin.
www.erowid.org
Scroll to the "with mescaline section"
Click to expand...

If you combine MAOI compounds with other phenethylamine compounds, the results could be disastrous, so I was entering into this combination with extreme caution, though with mescaline the mono amine oxidase combination appears to be relatively safe...

-eg
 
From purely pharmacological perspective that would be correct.

In my personal experience, over many attempts at various doses with this combo, I didn't really find harmalas made the mescaline/cactus more intense than I would have expected for the same dose sans harmalas. Certainly nothing like the many fold increase of intensity with something like psilocybin. It does add a nice harmala vibe to the cactus experience and it really is lovely, def one of my favorite combinations.

I never tried it with loph's which have a moar complex alkaloid content than trich's, so I can't speak to how harmalas may interact with the various other alks in there. A bit of caution would probably be advised but I don't expect you'll run into any problems.
 
oh gee man I would love that... but unless I can make it out to the boonies early that day I may have to just changa my face at home.

and as an edit... I don't know that I've ever eaten mescaline without harmalas. Always turns out A-OK
 
dreamer042 said:
From purely pharmacological perspective that would be correct.

In my personal experience, over many attempts at various doses with this combo, I didn't really find harmalas made the mescaline/cactus more intense than I would have expected for the same dose sans harmalas. Certainly nothing like the many fold increase of intensity with something like psilocybin. It does add a nice harmala vibe to the cactus experience and it really is lovely, def one of my favorite combinations.

I never tried it with loph's which have a moar complex alkaloid content than trich's, so I can't speak to how harmalas may interact with the various other alks in there. A bit of caution would probably be advised but I don't expect you'll run into any problems.
Click to expand...

Hmmm...

The goal is not to "intensify" anything, it's to prevent the destruction of a mono amine (mescaline) from your endogenous defense system against such compounds (mono amine oxidase enzymes). Thus increasing dose efficiency.

I've always assumed that you must dose high with mescaline, as a good deal of it is subject to destruction via mono amine oxidase enzymes, it can take near a gram (800mgs) to produce a peak experiance...

...now, if you took the mono amine oxidase enzymes out of the equation, what would an effective to peak dose look like? 80mgs-100mgs? Compared to 800mgs (or 200-400mgs ; PIHKAL) I would say that's quite an improvement.

Other phenethylamines and alpha-methyl-phenethylamines can have some very serious side effects when combined with an MAOI...Hypertension, heart problems, psychological distress, etc...Though in the case of mescaline, these risks are non-existent to minimal.

The shulgin anecdotes seem to confirm that if your MAO is inhibited, low doses of mescaline become effective.

experiments using only mescaline at doses between 80 and 120 mg resulted in no CNS effects at all, it seems clear that the MAO blocking effects of the harmaline were crucial to this experience.
https://www.erowid.org/l...e/tihkal/tihkal13.shtml
Scroll to the "with mescaline section"
Click to expand...

if you want as much of a mono amine to reach your system as possible, you would inhibit your enzymes which breakdown these compounds, your mono amine oxidase enzymes.

At the levels of harmala alkaloids used, there should be very little to no psychological action, you are simply inhibiting mono amine oxidase, without increasing the dose to the point of intoxication.

I'm confident it will work, producing psychedelia at least to some degree, at a much much lower dose.



-eg
 
I might be bailing come 4/20...

mescal and mary sitting in a tree...
T-R-Y-P-I-N-G
First Cums Love
Then Comes the cops
Then Comes the adrenaline rush...
 
Hoping to join in this SHE. I did a 69ron tek on some decent san pedro powder and now have just over a gram of tan waxy acetate crystals. Tried a minuscule amount to test, maybe 50mg and there were noticeable effects so that bodes well. Is there some kind of plan? Maybe focussing on something at a certain time of the day.
 
Bumping this one again to inspire a the slackers and procrastinators to get to work. You kids don't have too much bicycle day fun now, we still got 420 day and a SHE day on the horizon.
 
Surprisingly i NO BUYING/SELLNG, and surprisingly in my work schedule on 22 and 23 im free.
So i guess 22 is a nice date to experiment with the cacti. Im not sure about the chat, i'll be somewhere in the nature, but you never know right ..:)

Have a good time everybody, see you around:love:
 
My new little cactus babies are too scared to be eaten! NO BUYING/SELLNG There might be one in there that I can eat, since I doubt that I'll have time to process it, but I think that still counts.

So, here's to hoping that SS delivers in time and get to join you guys! I'll be in chat that night either way cheering everybody on.

MoonMoon




edit: null, 40 pounds! :shock: oh boy, nice
 
uhm.. im so sorry about not choosing my words more wisely.

this was a gift from the mother nature:d

Hope you all having a great time !!:love:
 
Back
Top Bottom