Shulgin found little to no visual effects from harmine .....I believe ....with tests up to 400mg ...
With a whole lot of quality reports of it being a belligerent effecting compound .I'll see if I can post the link
Plus those test in the thread were on those tested .....not countless others for other research groups .....the mckennas and others....of course ....the nexus has some damn good testing :thumb_up:
Ok here is his personal assay on harmine .....which he states visuals might have occurred at around 900mg!!!!!!!!!! WOW, that's pretty high bar to have MIGHT be visual .
He also states what a nasty compound it is subjectively .
Entry #14 HARMINE from TiHKAL by Alexander & Ann Shulgin.
www.erowid.org
Verses visuals at around 100mg here under harmaline
Erowid Online Books : "TIHKAL" - #13 HARMALINE
On his accounts harmaline is more visual at around 150mg verses harmine
If banisteriopsis caapi .....
didn't contain harmaline .......where are the visuals in VINE ONLY brews coming from ? I'm betting harmaline
But in the case of maoi s a harmine compound seems well indeed the inhibitor for nndmt breakdown , with his quote here on harmine
"As with harmaline, a number of drug combinations have been studied using harmine as the potential deaminase inhibitor. This is, after all, much closer to the basic structure of ayahuasca, where the plant Banisteriopsis caapi is the native inhibitory component, and it contains much more harmine than harmaline. In measured experiments, the use of harmine in the 140 to 190 milligram range, administered with 35 to 40 milligrams DMT, produced unmistakable effects lasting from one to three hours. Trials with smaller amounts, with 120 to 140 milligrams of harmine and 30 milligrams of DMT produced no signs of central activity at all. Harmine apparently is an effective, although modest, promoter of oral activity of DMT. At least this occurs at levels where it itself is substantially without action, so here it may truly be a facilitator rather than a participant."
In a minute I'll post a link done by the meckennas on the amounts of harmaline they found in various banisteriopsis caapis from different South American countries as far back as the 70s.
"When Holmstedt worked them up some 30 years ago, he reported that the alkaloid content was 0.4%. This was virtually identical to a newly collected, botanically verified specimen of Banisteriopsis caapi which he analyzed at the same time and found to contain 0.5% alkaloids. The latter material contained, as described by many authors, the main alkaloids harmine, harmaline and tetrahydroharmine. By contrast, the alkaloid content of the Spruce material consisted exclusively of harmine. It is open to question whether the samples collected by Spruce in 1853 originally contained only harmine or, perhaps more likely, that harmaline and tetrahydroharmine have with time been transformed into the chemically more stable aromatic b-carboline harmine."
shulgins quote on harmaline in banisteriopsis
I'm still looking for the erowid paper on harmaline in caapi and I'll post it shortly as I've seen it and know it's there
" harmaline at levels of 0.05 to 0.38% [averaging 0.19%] (but said to be absent from some other samples) "
That was from the meckennas.
Attached below is the link to the erowid page discussing harman , harmine , harmine and the in banisteriopisi caapi
Ok here it is by trout with harmaline levels existing.
Erowid Online Books : "Ayahuasca: alkaloids, plants, and analogs" by Keeper of the Trout.
The most interesting thing I find about the article is that percentage of alkaloids are higher in the leaves on average . Which is why I tend to harvest more leaf than vine and can vouch personally for the leaf brews being effective just more tannic
Seemingly
So meckenna 1984 states harmaline in caapi samples representing 9-20 percent of total alkaloids in samples