I have done everything with the stuff I could think of, including smoking large doses during ayahuasca peaks, snorting it with harmalas, combining with cacti etc..
In terms of healing and benefits from the trip I have found that bufotenine can actually take away from that because all you can focus on is the horrible constriction and toxic feeling nausea. If you can get past that, it produced some of the most stunning visionary experiences possible.
I will use it infrequently I am sure in my life for those really high def far out tryptamine visions. Once every few years and I am good.
I only had o3 bufotenine trips for me that really stand out as entheogenic experiences I grew as a person from on some level.
I would say for anyone really interested in it, try smoking and snuffing high dose bufotenine once just to see it. It is stunning. I really do feel like people should be careful with it though, esp anyone with heart conditions. I don't care so much that officially the LD50 for bufotenine is listed as higher than DMT. I do not feel that bufotenine is safer than DMT or 5-MeO-DMT physically. I think it is more dangerous. Alternatively, it is much safer psychologically. I would be quite hard to freak out on bufotenine(unless combined with other tryptamines/phnethylamines) from anything other than the alarming body effects. It really does lack the mental effects of other tryptamines for myself, leaving it feeling less magical and profound. DMT and 5-MeO-DMT can leave some people terrified and traumatized for a period.
I would never suggest a person actually ingest bufotenine orally. It will convert to an acid before first pass metabolism and you will feel absolutely horrible...think gangreen.
When using this molecule for a few nights in a row I once had a muscle ache in my leg for days after. The vasoconstriction is no joke. If you dont like LSA constriction, well bufo is multiples of that.
Please be careful with this tryptamine. I don't mean to frighten people, and I certainly took it enough while I was exploring it...