Mayahuasca
For several years there has been considerable speculation that the pre-Columbian Maya may have used a psychoactive ritual drink that was an ayahuasca analog. It has been conjectured that the Mayans used a Banisteriopsis species that grows in the Mesoamerican lowlands in combination with a source of DMT to make "mayahuasca" (Hyman 1994). It is entirely possible that Banisteriopsis miricata was used for this purpose, as its stems contain harmine and its leaves DMT. In other words, it is possible that an ayahuasca analog was made from just one plant.