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Cannabis as an anti-psychotic?

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AwesomeUsername

AwesomeUsername

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I've heard some constituents of cannabis have anti-psychotic effects but I haven't tasted it in how efficient it actually is. I'm afraid I might be showing some psychotic symptoms already and I don't want it manifesting further into an illness.

Having tried actual anti-psychotics, benzos, anti-depressants etc in the past I have no desire to seek those "medication" again, as it only makes me an non-functional zombie which I can't afford and needless to say don't want to afford. I want a normal life.

My case isn't really that bad, but I can get a little lost at work, a bit carried away in my free time and occasionally keep me from sleep. It becomes apparent at night time mostly, I get delusional and get closed-eye visuals which sometimes make me scared. I also used to have very frequent night mares, and that would result in me having a break in the middle of the night, not being able to control a single thought that came in my head. A truly scary place to be considering it wasn't drug induced.

Back to my original question, would smoking cannabis or hashish during nighttime help with my issues and keep me more centered through out the day or is it not that potent of a anti-psychotic? Also I can't be bothered to pay loads of cash for cbd oil or extract it myself, since I have no time and no money to source it because of my job.
 
AwesomeUsername said:
It becomes apparent at night time mostly, I get delusional and get closed-eye visuals which sometimes make me scared.
Click to expand...

Can you describe them, perhaps? I'm curious as to how they manifest.

When I'm in a bad mindspace, usually when I'm tired, fatigued or have eaten something my body doesn't agree with, my mind will go into a storm of delusional thoughts, which are very difficult to control... my mind feels quite lopsided during those times, if that makes sense.

I used to smoke Cannabis, but it just makes me feel like a zombie now... meditation helps... but not if I'm already lost in the storm.
 
Cannabis is great for bipolar, ADD, and some types of depression, but can be terrible for schizophrenia, delusional disorders, and certain types of psychosis...

This is what I have observed any way...

-eg
 
I would echo the suggestion to look into CBD. I would strongly suggest avoiding THC (even the small amounts in a strain like Charlotte's Web). THC can absolutely exacerbate psychotic symptoms. CBD is readily available, and as long as it's sourced from hemp (and not from that devil marijuana) it's completely legal in all 50 states (for now, the DEA and FDA are trying hard to stamp it out as we speak) and in many (most?) countries around the world.
 
I would strongly suggest avoiding THC [...]
Click to expand...
With this I would certainly concur - I have known several people developing psychotic symptoms after smoking strong herbal cannabis habitually for a time. What usually happens is that it's all fun and games to start with but, life being life and all, when adverse circumstances inevitably arise there is a subset of those among us who respond negatively to the thought-amplifying effects of THC. Then the best option is laying off the green for a good while and learning the tricks of positive thinking and probably NLP.

NLP and CBD, not THC!
 
Valmar said:
AwesomeUsername said:
It becomes apparent at night time mostly, I get delusional and get closed-eye visuals which sometimes make me scared.
Click to expand...

Can you describe them, perhaps? I'm curious as to how they manifest.

When I'm in a bad mindspace, usually when I'm tired, fatigued or have eaten something my body doesn't agree with, my mind will go into a storm of delusional thoughts, which are very difficult to control... my mind feels quite lopsided during those times, if that makes sense.

I used to smoke Cannabis, but it just makes me feel like a zombie now... meditation helps... but not if I'm already lost in the storm.
Click to expand...

Yes I can, the visuals are very ayahuasca-like. I see patterns of colors that are not very detailed but definitely there. Occasionally I see people too, sometimes it looks tribal, sometimes I'll see an angry guy yelling but I can't understand a word and other times there will be some creepy doll like creatures that you probably have seen in a bad cartoon or so.

The mindspace is like talking to yourself and getting yelled at. For example a thought comes by, and the "other you" yells and you freeze out of fear, and forget what you were going to say or in this case think. Combine all that I told you and this is how I feel almost every night.

Before I actually used psychedelics to escape this "normal but not normal state", I would attribute me feeling crazy to being on drugs and that was actually at that time relieving. I haven't used psychedelics or any drugs since new years.
 
I would like to echo recommendations about avoiding THC, but looking into CBD. THC is fully capable of inducing psychotic states in those predisposed to it, so I would highly recommend giving it a wide berth. Cannabis contains many different cannabinoids with their own effects, but it's really important we distinguish CBD from THC from the outset...it is more useful in this case I think to consider individual compounds rather than the plant as a whole. It is pretty easy to source CBD in pure form with no THC, and one can use it in the form of a vape-pen, I have one of these which I enjoy using.

I remember reading a study, which I can't seem to track down, which claimed that CBD is as effective as any available anti-psychotic medications, but without the side effects or toxicity of these.

Some studies here looking at CBD's anti-psychotic potential.




link.springer.com

Effects of cannabidiol in animal models predictive of antipsychotic activity - Psychopharmacology

The effects of cannabidiol (CBD) were compared to those produced by haloperidol in rats submitted to experimental models predictive of antipsychotic activity. Several doses of CBD (15–480 mg/kg) and haloperidol (0.062–1.0 mg/kg) were tested in each model. First, CBD increased the effective doses...
link.springer.com link.springer.com

www.scielo.br

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug

A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component,...
www.scielo.br www.scielo.br
 
entheogenic-gnosis said:
In this PDF an individual with bi-polar disorder explains how cannabis and psilocybin helped heal him.

-eg
Click to expand...

Again, cannabis, including the THC, can be great for mania, bipolar, PTSD, ADD, and certain types of depression, but when it comes to schizophrenia, certain types of psychosis, delusional disorders, and so on, it can actually make things much worse.

-eg
 
Again, is it not more useful to consider individual cannabinoids separately? Cannabis...when considered in whole plant form...may indeed exacerbate or induce psychotic or schizophrenic episodes in those predisposed to it, due in large part to the presence of THC. This does NOT apply to CBD in isolation, which has well documented anti-psychotic effects (see previously linked studies). So better I think to be more specific when discussing cannabis as it contains varying proportions of hundreds of different cannabinoids.
 
My girlfriend has BPD and we smoke hash daily. She says it calms her and helps her concentrate. She also takes 60mg duloxetine 2x daily which causes her to have occasional tremors and I've noticed when we've had hash and we're falling asleep her tremors are a lot calmer.

Straight cannabis makes her hallucinate some and say strange stuff. Most strains anyway. Some have the same effect as the hash we smoke.
 
I used to grow a high CBD cannabis called Pearl for my wife’s neuropathy and also for several other people. One of these said to me, “When I have Pearl, I am not bipolar!” Many others confirmed this.
 
Bancopuma said:
Again, is it not more useful to consider individual cannabinoids separately? Cannabis...when considered in whole plant form...may indeed exacerbate or induce psychotic or schizophrenic episodes in those predisposed to it, due in large part to the presence of THC. This does NOT apply to CBD in isolation, which has well documented anti-psychotic effects (see previously linked studies). So better I think to be more specific when discussing cannabis as it contains varying proportions of hundreds of different cannabinoids.
Click to expand...

I suppose it would be useful to consider these cannabinoids individually, however, the majority of the time it is cannabis flowers or extracts, (all of which contain primarily THC as well as the other cannabinoid components of the plant) which are most often being consumed, even in cases in which people are seeking to treat mental disorders.

It's been shown that the natural combination of these substances contained in the raw plant matter has been very benneficial for certain disorders, particularly bipolar, mania, hyperactivity, PTSD, and so on, and in these cases I feel the plant matter, with all of its combined substances, is the actual medicine that should be investigated.

If you can separate all these cannabinoids and terpenoids/terpenes, and can study them individually, this is great, and I'm sure that much will be yielded from such endeavors, however, examining the plant as a whole, in the manner which it is most commonly consumed, is equally as valuable and should not be discounted.

-eg
 
rild said:
I used to grow a high CBD cannabis called Pearl for my wife’s neuropathy and also for several other people. One of these said to me, “When I have Pearl, I am not bipolar!” Many others confirmed this.
Click to expand...

I think the THC may be just as benneficial as the CBD regarding bipolar individuals... you will constantly hear from bipolar individuals that cannabis is the most effective medication for their disorder, and I personally feel that the THC is key to this.

If you have ever known a bipolar person, and you have seen them start to go into a mania, then you have seen them counter it (almost instantly) by smoking cannabis, I'm sure you would be leaning more towards the THC as the benneficial compound...but again, I'm sure all of these cannabinoids are helping in some way.

-eg
 
Just lumping everything into the umbrella term "cannabis" is also a bit of a misnomer here. In particular hemp varieties and landrace varities of the species Cannabis ruderalis, which are both very low in THC, yet still contain a nice spectrum of other cannabinoids, would be interesting to look at as whole plant alternatives to purified CBD.
 
entheogenic-gnosis said:
I think the THC may be just as benneficial as the CBD regarding bipolar individuals... you will constantly hear from bipolar individuals that cannabis is the most effective medication for their disorder, and I personally feel that the THC is key to this.
Click to expand...
Is this (the part in bold) statement based on personal experience, based on experiences communicated to you personally, or third order hearsay?

I strongly doubt your statements. My personal impression, based on first, second and third order experience is that thc tends to exacerbate bipolar disturbances and tendencies, while cbd ameliorates these. Scientific research also appears to back this up. In "Current Pharmaceutical Design, Vol 18, Number 32, November 2012" (Current Pharmaceutical Design: Ingenta Connect Table Of Contents) you'll find dozens of such articles.

A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation - PubMed
A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.
Zuardi AW, Crippa JA, Hallak JE, Bhattacharyya S, Atakan Z, Martin-Santos R, McGuire PK, Guimarães FS.
Curr Pharm Des. 2012;18(32):5131-40.
DOI: 10.2174/138161212802884681

Abstract:
Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is the main compound of the Cannabis Sativa responsible for most of the effects of the plant. Another major constituent is cannabidiol (CBD), formerly regarded to be devoid of pharmacological activity. However, laboratory rodents and human studies have shown that this cannabinoid is able to prevent psychotic-like symptoms induced by high doses of Δ(9)- THC. Subsequent studies have demonstrated that CBD has antipsychotic effects as observed using animal models and in healthy volunteers. Thus, this article provides a critical review of the research evaluating antipsychotic potential of this cannabinoid. CBD appears to have pharmacological profile similar to that of atypical antipsychotic drugs as seem using behavioral and neurochemical techniques in animal models. Additionally, CBD prevented human experimental psychosis and was effective in open case reports and clinical trials in patients with schizophrenia with a remarkable safety profile. Moreover, fMRI results strongly suggest that the antipsychotic effects of CBD in relation to the psychotomimetic effects of Δ(9)-THC involve the striatum and temporal cortex that have been traditionally associated with psychosis. Although the mechanisms of the antipsychotic properties are still not fully understood, we propose a hypothesis that could have a heuristic value to inspire new studies. These results support the idea that CBD may be a future therapeutic option in psychosis, in general and in schizophrenia, in particular.
 

Attachments

I do some cannabis extraction including lots of CBD extraction. The BPD people that I see tend to like THC but clearly respond extremely well to CBD. I have produced three extracts with lots of THC and another cannabinoid in the five to fifteen percent range. The other cannabinoids in the three extracts were each different and not CBC, CBG, CBL, THCV, CBDV, or d8THC. Two of these extracts were extremely well liked by some with emotional issues. I would have sent a sample to a test lab but no lab could legally take the sample. Nor could I mail it. When pot is a little more legal, some good will come it.
 
pitubo said:
entheogenic-gnosis said:
I think the THC may be just as benneficial as the CBD regarding bipolar individuals... you will constantly hear from bipolar individuals that cannabis is the most effective medication for their disorder, and I personally feel that the THC is key to this.
Click to expand...
Is this (the part in bold) statement based on personal experience, based on experiences communicated to you personally, or third order hearsay?

I strongly doubt your statements. My personal impression, based on first, second and third order experience is that thc tends to exacerbate bipolar disturbances and tendencies, while cbd ameliorates these. Scientific research also appears to back this up. In "Current Pharmaceutical Design, Vol 18, Number 32, November 2012" (Current Pharmaceutical Design: Ingenta Connect Table Of Contents) you'll find dozens of such articles.

A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation - PubMed
A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.
Zuardi AW, Crippa JA, Hallak JE, Bhattacharyya S, Atakan Z, Martin-Santos R, McGuire PK, Guimarães FS.
Curr Pharm Des. 2012;18(32):5131-40.
DOI: 10.2174/138161212802884681

Abstract:
Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is the main compound of the Cannabis Sativa responsible for most of the effects of the plant. Another major constituent is cannabidiol (CBD), formerly regarded to be devoid of pharmacological activity. However, laboratory rodents and human studies have shown that this cannabinoid is able to prevent psychotic-like symptoms induced by high doses of Δ(9)- THC. Subsequent studies have demonstrated that CBD has antipsychotic effects as observed using animal models and in healthy volunteers. Thus, this article provides a critical review of the research evaluating antipsychotic potential of this cannabinoid. CBD appears to have pharmacological profile similar to that of atypical antipsychotic drugs as seem using behavioral and neurochemical techniques in animal models. Additionally, CBD prevented human experimental psychosis and was effective in open case reports and clinical trials in patients with schizophrenia with a remarkable safety profile. Moreover, fMRI results strongly suggest that the antipsychotic effects of CBD in relation to the psychotomimetic effects of Δ(9)-THC involve the striatum and temporal cortex that have been traditionally associated with psychosis. Although the mechanisms of the antipsychotic properties are still not fully understood, we propose a hypothesis that could have a heuristic value to inspire new studies. These results support the idea that CBD may be a future therapeutic option in psychosis, in general and in schizophrenia, in particular.
Click to expand...

While CBD May be great for treating other psychotic disorders, particularly ones which THC would exacerbate like schizophrenia, and while it may also help bipolar, I see the THC as being very beneficial for those with bipolar.

From first hand experience, I have seen a many bipolar people effectively pull themselves out of manic episodes with cannabis, ans while CBD May have helped, it was the THC that had the immediate effect, and which prevented the manic episode from occurring.

The studies claiming cannabis is detrimental for those with bipolar have been disputed in their methods and results, and further studies only show cannabis having a benneficial effect for individuals with bipolar.


Extract

INFO

News
Marijuana may help bipolar patients manage moods, study finds

WRITTEN BY EMILY GRAY BROSIOUS POSTED: 07/11/2016, 04:11PM

Marijuana may help bipolar patients manage moods, study finds(Image credit: deux/Corbis)

New research challenges assumptions about marijuana use among bipolar patients.

Marijuana is the most widely used illicit drug among the general public and among people diagnosed with bipolar disorder, also known as manic depression.

While prevailing wisdom has long assumed marijuana exacerbates mood problems in bipolar patients, there’s actually very little conclusive evidence about what effects the drug has on clinical symptoms of this debilitating mood disorder.

Researchers from Harvard Medical School, Tufts University and McLean Hospital in Massachusetts recently set out to clear the fog on this issue in a study published online June 8, 2016 in the journal PLOS One.

As outlined in the study, entitled “Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood”:

Although many studies have reported that marijuana use precedes the onset of bipolar disorder, it remains unclear whether marijuana use contributes to the pathogenesis of the disorder, or if it is used to address symptomatology, perhaps as a form of premorbid self-medication, especially if traditional pharmacotherapeutic regimens are ineffective at symptom alleviation.

Further research is needed to clarify the relationship between marijuana use and the manifestation of bipolar disorder symptoms. Despite claims of negative outcomes associated with marijuana use, whether patients’ view marijuana use as successful in symptom improvement is rarely assessed.

Researchers’ latest findings shed new light on the topic and suggest marijuana use may actually improve mood stabilization in patients diagnosed with bipolar disorder.

The study followed 12 bipolar patients who smoke marijuana, 18 bipolar patients who do not smoke marijuana, 23 marijuana smokers without bipolar disorder and 21 healthy controls who don’t smoke marijuana.

Participants rated their moods three times daily as well as after each time they used marijuana over the course of four weeks.

No significant differences were noted between cognitive function in bipolar patients that smoked marijuana and those who didn’t.

Furthermore, bipolar participants who regularly smoked marijuana reported notable reductions in mood symptoms each time they used the drug.

The findings suggest marijuana use may partially alleviate the clinical symptoms of bipolar disorder for some patients.

This study is limited by its small participant size and preliminary nature, which did not investigate the relationships between specific patterns or levels of marijuana use and symptom improvement.
Click to expand...

In a literature review, researchers from the University of Newcastle upon Tyne in the United Kingdom examined the relationship between cannabinoids and bipolar affective disorder. They concluded that both tetrahydrocannabinol (THC) and cannabidiol (CBD) from medical marijuana are similar to standard medications being used to treat bipolar affective disorder. Based on this finding and the mounting evidence that THC and CBD can affect synaptic action, the researchers feel that patients with bipolar affective disorder could benefit from medical marijuana.
Click to expand...

Do you personally know any bipolar individuals who medicate with cannabis? I can tell you from first hand experience that cannabis can be amazing for certain bipolar individuals, it's effective, and it often works better than any of the pharmaceutical mood stabilizers given to these individuals. I have watched an individual counter manic states with cannabis, this individual can tell when mental shifting into a manic state is about to occur, this individual will get all the early symptoms of this manic state, all the physical and mental ques, then will smoke cannabis, and like magic this individual will be back to a more or less baseline functioning mental state. I have a bipolar ex-girlfriend, and it's the same case, she is a nightmare without cannabis. This is a case where it's not just "review some studies and take a side" I have actually seen this work.

This PDF published by MAPS offers further anecdotal evidence of an individual who treated his bipolar with cannabis.


-eg
 

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