Certain Exotic Transmitters as SMART PILLS or Compounds that Increase the Capacity for Mental Work i

[entheogenic-gnosis]

Researching many of these ethoxy and diethoxy homologues of known phenethylamines and amphetamines, was particularly curious about

74 EEM

2,4-DIETHOXY-5-METHOXYAMPHETAMINE
DOSAGE: unknown.

DURATION: unknown.

EXTENSIONS AND COMMENTARY: This particular identity and arrangement of the alkoxy groups on the amphetamine molecule, EEM, is a totally unexplored molecule. It is reasonable to assume that it would be way down in potency, but there is no way of guessing what the nature of its activity might be at the dosage that would be active.
-shulgin;PIHKAL

-eg

 

[downwardsfromzero]

From what I've read in Lazar's SP about SAR's it would be a complete waste of time, as Shulgin suggests. MEE would surely be better.

 

[entheogenic-gnosis]

From what I've read in Lazar's SP about SAR's it would be a complete waste of time, as Shulgin suggests. MEE would surely be better.

...bummer, nothing is more tantalizing than an unknown activity entry for a potentially psychedelic molecule. I guess EEM has no potential as a nootropic? Does it have any activity at all? And if it is completely inactive, that in itself should be interesting...


Any way, here is what lemaire had to say in "smart pills" regarding ethoxy substitutions to known active phenethylamines:

Several subjects, in addition to Meg, found that 2CD was a little too strong for them; they mostly felt that it "wired them up" excessively. The compound was tamed by replacing the two methoxy groups on the ring with two ethoxy groups and resulted in 2CD-DiEt (4-Methyl-2,5 diethoxyphenethyl- amine) which retained the smart pill activity and eliminated the tendency towards states of intoxication. Along this same line of reasoning, two other compounds were made where only one of the methoxy groups was replaced with an ethoxy group. Since there are two methoxy groups to replace, this resulted in two more compounds 2CD-2EtO (4-Methyl-2- ethoxy-5-methoxy-phenethyl-amine) and 2CD-5EtO (4- Methyl-2-methoxy-5-ethoxy-phenethyl-amine). The first compound, 2CD-2EtO, did not show any smart pill activity in initial trials and was not pursued further. The second compound, 2CD-SEtO, did show some very interesting properties in this area which will be covered under it's own heading later

Erowid 2C-D Vault : Smart Pills, by Hosten & Lazar

Certain Exotic Neurotransmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans, by Hosten & Lazar

erowid.org

2CD-DiEt
4-Methyl-2,5-Diethoxyphenethylamine 5

As mentioned earlier, this compound was synthesized to eliminate some unwanted side effects in some individuals and yet retain the smart pill activity. In this respect the effort was very successful and this compound was used more than 2CD for general learning tasks. The dosage used with this material was a little wider than for 2CD and was generally in the range of 5 to 15 milligrams orally. Again each individual selected their own dosage based on usage, optimum results and intuition.

In general the results obtained with 2CD-DiEt were not quite as dramatic as those with 2CD, indicating a reduction of smart pill activity, but still made it a good general purpose aid for learning. Several people have used this material daily for periods of two or three weeks, without noticing any adverse effects from a physiological standpoint. LAZAR feels that this is a very worthwhile compound and for future investigations the diethoxy substitutions should not be overlooked.


2CD-5EtO
4-Metyl-5-Ethoxy-2-Methoxyphenethylamine (5)

This was synthesized as part of the exploration of position analogs of 2CD and was found to have some different properties than 2CD or 2CD-DiEt. At doses of from 5 to 10 milligrams (in a few individuals up to 12.5 mg) it was found to produce a state very well suited for reading with incredibly good understanding and retention. Some persons reported that they could "grok" or understand very deeply the intent of the author when she/he wrote the material being read. Others reported basically the same thing, but expressed it in a different way: "I could tell where the author was coming from when the material was being written." This compound had a longer time span of activity than the two mentioned previously, with some people reporting the material active for up to ten hours. This fits in with tests done with the compound at levels as high as 40-50 mg which produced a psychedelic experience lasting approximately 12 hours. There was no visual distortion, and color enhancement was noted by most. All agreed that it could best be described as an "art gallery tour", as paintings, drawings, sculptures, and just ordinary "knick knacks" took on a life of their own and one could spend many minutes gazing at an object with intense fascination. No negative feelings were experienced by any of the testers and everyone agreed that it was a very smooth and positive experience. Most felt that they had gained important insights into their lives. The 2CT2 series of compounds were investigated for smart pill activity. The parent compound 2,5-Dimethoxy-4- Ethylthio-phenethylamine was tested for smart pill activity and the results were not very interesting, so various methyl/ethyl positional isomers were made to check out this area. The three compounds that resulted and were evaluated to some extent were: 2CT2-2EtO, 2CT2-SEtO, and 2CT2-DiEt.


2CT2-2EtO
2-Ethoxy-5-Methoxy-4-Ethylthiophenethylamine (6)

This was tested at levels of from 10 to 20 mg. Test subjects reported a general heightening of sensorial awareness and some, but not all, felt it could be most useful for creative enterprises. Exploring dosage levels of less than 10 mg may prove to be interesting, but at levels of more than 20 mg hallucinogenisis was noted and this condition was not appropriate for studying. In all cases the duration of action was shorter that other compounds tested; about four hours duration was noted in most cases.


2CT2-5EtO
2-Methoxy-5-Ethoxy-4-Ethylthiophenethylamine (6)

This was tested at levels of from 5 to 10 mg and a very interesting property of this material was noted: The effects lasted for 22 to 23 hours and with most subjects no sleep was possible during that time unless some Halcion or Valium was taken to allow a few hours sleep. This compound was classed as very insightful and useful for forming new concepts and writing them down. One disadvantage was that it was so long acting.


2CT2-DiEt
2,5-Diethoxy-4-Ethylthiophenethylamine (6)

This was tested at levels of from 5 to 15 mg. The effects lasted for only three hours and users reported that reading was very easy with good concentration and assimilation. The three thio compounds listed above were the only ones checked for smart pill activity. LAZAR feels that the manipulations with ring substituents on a dozen or more other thio compounds could be most interesting and rewarding. The reason more work was not done in this area was the passage of the "Controlled Substances Analog Bill".


2CE-5EtO
4-Ethyl-5-Ethoxy-2-Methoxyphenethylamine

This was the only compound of the 2CE series evaluated for smart pill activity. It was found to be like its 5-Ethoxy counterpart of the 2CT2 series to be very long acting, about 24 hours with little or no sleep possible without Halcion. Dosages ranged from 5 to 16 mg and it generally took about two hours for the material to become effective after ingestion. In one test three subjects took the material together and read an entire book of over 300 pages, taking turns reading aloud. The following day after a little sleep, they discussed the content of the book and found that they could quote entire paragraphs and their understanding and retention was excellent. All three were quite impressed with the entire test. The feeling was that this would be good for brain-storming or other similar small group activities. They also felt that the material could manifest philosophical overtones during the time the material was active.

-eg

 

[JAi]

I can see it now "I'm on the 2CD Diet pill" .

Anyway as cognitive science shows, the accuracy of our decision making mode decreases after a certain point when enough is enough. We could easily do trials that use exhaustive tests to get a base normal for each person and compare it to the specific noo-chem to see if the amount of time we can stay in decision making mode changes. I would expect it to extend the length of decision making sessions, but if it shortened it it might be that we're exuding more energy in a smaller period of time.

I've read somewhere there are healthy 90 minute cycles but that we can only do so much in a day before decisions are less accurate than while we have all the mental energy earlier in the day, presuming there was adequate sleep (another variable).

The 4 main cognitive states are the focused flow state and the relaxed daydreaming state, as well as the attention all filter and the switching mechanism between the focused and relaxed states.

I we can't measure what these do, how do we know the benefit is worth the risk?

 

[entheogenic-gnosis]

I can see it now "I'm on the 2CD Diet pill" .

Anyway as cognitive science shows, the accuracy of our decision making mode decreases after a certain point when enough is enough. We could easily do trials that use exhaustive tests to get a base normal for each person and compare it to the specific noo-chem to see if the amount of time we can stay in decision making mode changes. I would expect it to extend the length of decision making sessions, but if it shortened it it might be that we're exuding more energy in a smaller period of time.

I've read somewhere there are healthy 90 minute cycles but that we can only do so much in a day before decisions are less accurate than while we have all the mental energy earlier in the day, presuming there was adequate sleep (another variable).

The 4 main cognitive states are the focused flow state and the relaxed daydreaming state, as well as the attention all filter and the switching mechanism between the focused and relaxed states.

I we can't measure what these do, how do we know the benefit is worth the risk?

I'm not sure exactly what it is that you are trying to say, if you would care to clarify it would be much appreciated.

-eg