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Certain Exotic Transmitters as SMART PILLS or Compounds that Increase the Capacity for Mental Work i

Migrated topic.
Certain Exotic Transmitters as
SMART PILLS
or Compounds that Increase the Capacity for Mental Work in Humans
A story about LAZAR as told by Hosteen Nez

Actual author was Darrell Lemaire*

Rather than copy and paste excerpts from this work I felt it should be viewed in its entirety as in the above link.

As erowid noted:
[Erowid note: The following booklet is a little overly positive because it fails to detail any negative reactions, negative health effects, or any other negative elements of any of the compounds discussed.]

However, I still find this work a valuable insight into bioassays regarding these amazing molecules.

---------

Darrell Lemaire
*1968 he sold his company for a good price; he was able to retire at the age of 42, and his underground machine shop became a wine cellar. That same year, he and his wife got divorced.

With ample free time on his hands, Lemaire began to look more closely at psychoactive drugs, beginning with Cannabis. Inspired by his later experiences with mescaline and methylenedioxyamphetamine (MDA), and disheartened by the spotty black market for psychedelics, Lemaire decided to manufacture his own medicine. In 1969 he began to research and synthesize psychoactive compounds that were or might be useful as adjuncts for psychotherapy.

In 1976, Lemaire married Betty Lamb, who often accompanied him on his psychonautical sojurns. During that same year, Lemaire was one of three chemists (the other two being David Nichols and Sasha Shulgin) who were inspired, independently, to synthesize and bioassay what they suspected might be a psychoactive drug with interesting effects: 3,4-methylenedioxymethamphetamine (MDMA), an analog of the "love drug" methylenedioxyamphetamine (MDA), which had been put into Schedule I six years earlier. Having previously found MDA of great psychotherapeutic value, it occurred to Lemaire to synthesize the methamphetamine analog, MDMA, and see whether or not it might be a useful substitute for the scheduled amphetamine compound. After making some and trying it, he felt that MDMA was even better in many respects than MDA.

Lemaire's research led him to Shulgin's publications in the field, inspiring him to synthesize a novel ring-substituted beta-methoxyphenethylamine. As a structural analog of the neurotransmitter noradrenaline, Lemaire's compound represented an entirely new class of psychedelic drug. After Lemaire and Shulgin became friends in the early 1980s, Shulgin encouraged Lemaire to help medical doctors who wished to manufacture MDMA for use in their psychotherapeutic practices. Lending his assistance in this endeavor, at least 19.5 kilos of MDMA were produced in Lemaire's underground "wine cellar repurposed as an ecstasy production lab" before the medication was placed into Schedule I and he could no longer provide this service. He continued to make nonscheduled psychoactive compounds until the government instituted the Controlled Substance Analogue Enforcement Act of 1986, at which point he shut down his lab.

In 1990, using the pseudonyms "Lazar" and "Hosteen Nez", Lemaire summed up some of his earlier findings. Within a small, self-published, underground pamphlet titled Certain Exotic Neurotransmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans, Lemaire described the effects of 2C-D and its assorted ethoxy analogs, and presented several useful applications for these compounds. After over a decade with his lab equipment seeing no use, in the Spring of 2001 Lemaire gave the gear to Casey Hardison, a talented young chemist who had recently written an article on 2C-T-7 in the MAPS Bulletin that Lemaire had noticed.

In 2005, Joe Brown and Forrest Niccum hired Lemaire to help them with investigating the potential medicinal applications for some phytochemicals. Together they discovered that salicinium—a glucoside of 4-hydroxy-benzaldehyde, extracted from the plant Helicia nilagirica—shows great promise as a cancer treatment, with a survival rate in Stage 4 cancer patients of nearly 85%.

------

-eg
 
downwardsfromzero said:
2C-D and its homologs do indeed sound decidedly interesting. Thanks for posting.

For many reasons there are intrinsic prejudices regarding many of these novel and rare phenethylamines...however I feel most of these fears and prejudices are fully unjustified...

It bothers me that an individual can obtain a rare compound that they know little to nothing about, consume 100 times the accepted dose, become injured in some way or even possibly die, and then it is the compound that takes the blame and the compound that gains a bad reputation, when in reality it was lack of education and irresponsible chemical consumption that should be blamed, the errors were human.

the 2Cx, 2C-T-x and DOx series compounds are amazing, beautiful, and valuable tools.

Darrell Lemaire is an amazing individual, a person who truly deserves his place in psychedelia and psychedelic history, he was a pseudonymous and unknown figure by most up until 2015, and only recently has he decided to take his story public, at 90 years old it seems the time was right, this is history that needed to be saved.

I only hope that Mr. Lemaire and his story will act as a means of inspiring young chemists and researchers.

And I hope that the value of these amazing phenethylamines will not be lost...

--------

Other great, independent, phenethylamine research:

Sulfurous Samadhi
An Investigation of 2C-T-2 & 2C-T-7
by Murple


An Amateur Qualitative Study of 48 2C-T-7 Subjective Bioassays
BY CASEY HARDISON
Feb-June 2000



--------

-eg
 
downwardsfromzero said:
One day I hope to experience 2C-D. Apparently it has a very forgiving dose-response curve (a bit like mescaline).

You are in a position where you have the chemical knowledge to explore any molecule which you put the effort into, I only have 3 years organic chemistry, and yet I'm confident that I could easily conquer any synthesis work-up outlined in PIHKAL/TIHKAL...

Darrell is retired, shulgin has passed, D. E. Nichols decided to work in the system, Casey hardison retired, Nick sand retired, Owsley Stanley has passed, and so on...
In the Middle Ages, the church forbade dissection of human bodies, and medical students would visit battlefields and the gallows at night, and steal the bodies of victims of war and executed prisoners, in order to learn human physiology. Where that spirit of scientific courage has gone, I don't know; but there is very little of it left. Now, people feed at the trough of government grants and enormous corporate research budgets, and the idea of actually pursuing truth, or attempting to understand the phenomenon in an unbiased fashion, divorced from its commercial, social and political dimensions, is unheard of.
-terence McKenna

Any way...


2,5-dimethoxy4-methyl-phenethylamine is an amazing compound...I've been doing extensive research regarding its synthesis (as well as ganesha and DMMDA) and have made a great deal of progress...

I'm also interested in related molecules described by Darrell:

Meg, found that 2CD was a little too strong for them; they mostly felt that it "wired them up" excessively. The compound was tamed by replacing the two methoxy groups on the ring with two ethoxy groups and resulted in 2CD-DiEt (4-Methyl-2,5-diethoxy-phenethylamine) which retained the smart pill activity and eliminated the tendency towards states of intoxication. Erowid 2C-D Vault : Smart Pills, by Hosten & Lazar

In the excerpt below, it's obvious that shulgin was referring to Darrell's work:

I have learned of an extensive study of ethoxy homologues of a number of the phenethylamines in the 2C-X series; they have been collectively called the "Tweetios." This Sylvester and Tweety-bird allusion came directly from the compulsive habit of trying to alleviate the boredom of driving long distances (not under the influence of anything) by the attempt to pronounce the license plates of cars as they passed. The first of this series of compounds had a name that indicated that there was an ethoxy group at the 2-position, or 2-EtO, or Tweetio, and the rest is history. In every compound to be found in the 2C-X family, there are two methoxy groups, one at the 2-position and one at the 5-position. There are thus three possible tweetio compounds, a 2-EtO-, a 5-EtO- and a 2,5-di-EtO-. Those that have been evaluated in man are included after each of the 2C-X's that has served as the prototype. In general, the 2-EtO- compounds have a shorter duration and a lower potency, the 5-EtO- compounds have a relatively unchanged potency and a longer time duration; the 2,5-di-EtO- homologues are very weak, if active at all.

The 2-EtO-homologue of 2C-D is 2-ethoxy-5-methoxy-4-methylphenethylamine, or 2CD-2ETO. The benzaldehyde (2-ethoxy-5-methoxy-4-tolualdehyde) had a melting point of 60.5-61 °C, the nitrostyrene intermediate a melting point of 110.5-111.5 °C, and the final hydrochloride a melting point of 207-208 °C. The hydrobromide salt had a melting point of 171-173 °C. At levels of 60 milli-grams, there was the feeling of closeness between couples, without an appreciable state of intoxication. The duration was about 4 hours.

The 5-EtO- homologue of 2C-D is 5-ethoxy-2-methoxy-4-methylphenethylamine, or 2CD-5ETO. The benzaldehyde (5-ethoxy-2-ethoxy-4-tolualdehyde) had a melting point of 81-82 °C, and the details of this synthesis are given in the recipe for IRIS. The nitrostyrene intermediate had a melting point of 112.5-113.5 °C and the final hydrochloride salt had a melting point of 197-198 °C. The hydro-bromide salt had a melting point of 158-159 °C. At dosage levels of 40 to 50 milli-grams, there was a slow, gradual climb to the full effects that were noted in about 2 hours. The experience was largely free from excitement, but with a friendly openness and outgoingness that allowed easy talk, interaction, humor, and a healthy appetite. The duration of effects was 12 hours.

The 2,5-di-EtO- homologue of 2C-D is 2,5-diethoxy-4-methylphenethylamine, or 2CD-2,5-DIETO. The benzaldehyde (2,5-diethoxy-4-tolualdehyde) had a melting point of 102-103 °C, the nitrostyrene intermediate a melting point of 108-109 °C, and the final hydrochloride salt a melting point of 251-252 °C. At a level of 55 milligrams, a plus one was reached, and what effects there were, were gone after four hours.

-Shulgin;PIHKAL;2CD entry

5-eto compound retain potency, but possess increased duration...

2,5-diethoxy-4-methyl-phenethylamine is said to have nootropic properties consistent with 2C-D, but is relatively free from intense psychoactive states otherwise...





-eg
 
downwardsfromzero said:
One day I hope to experience 2C-D. Apparently it has a very forgiving dose-response curve (a bit like mescaline).

Quite forgiving indeed, and in general a very friendly molecule.

At low dose it's a nootropic:
(with 10 mg) There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a `smart' pill! -PIHKAL

At medium dose levels:
(with 75 mg) This is a +++, but the emphasis is on talking, not on personal interacting. I am putting out, but my boundaries are intact. I was able to sleep at the sixth hour. Communication was excellent. This is fast on, but not too long lived. Maybe a therapy tool?-PIHKAL

And at high dose levels:
(with 150 mg) A truly remarkable psychedelic, one which could compare favorably with 2C-B. There are intense colors, and I feel that more would be too much.
-PIHKAL

Shulgin also stated that:
This particular compound is what I call a pharmacological tofu. -PIHKAL
which is a great metaphor, but was initially misleading, it gives the impression that 2C-D does not do much on its own, but does great at enhancing other compounds...which is true, it is an enhancing agent, but its also an amazing compound on it's own. It's subtle (until you venture up in to the higher doses) but it's doing a good deal...if that makes sense.

It can be a fairly mild compound until you reach the higher dose range, but when you do obtain Full psychedelia from 2C-D it's an indescribable magic:

In an interview, Casey hardison asked Darrell lemaire "if you could have one last major trip before you go, what compound would it be?" (Or something to that effect) and Lemaire sharply replied "2C-D, and lots of it!"

-eg
 
Ray Chamberlain is an organic chemist who worked with Darrell Lemaire.

Dr. Chamberlain did some great work with 4-methyl-2,5,beta-trimethoxy-phenethylamine and 2,5- dimethoxy-4-methyl-beta-hydroxy-phenethylamine.

I'm having trouble locating Dr. Chamberlain's past work involving these compounds...

-eg
 
Darrell specifically mentions Ray in regards to working with the BOx series and tweetios, yet I can't find of the actual research or chemistry. It could be that nothing was ever published, though you figure that there would have been some documented research from the time when Darrell and Ray were working together...

If anybody has any information in regards to this please let me know.

-----

Misc. BOx information:

Back to the commentary on BOD. The rationale for this inclusion of a beta-oxygen atom into the structure of a phenethylamine is based directly on the chemistry that occurs naturally in the brain. The phenethylamine neurotransmitter, dopamine, is converted both in the brain and in the body to the equally important transmitter norepinephrine by just this sort of transformation. There is the enzymatic addition of an oxygen atom to the "benzylic" position of dopamine. And identical chemistry goes on with tyramine in a number of plants and animals, with a similar addition of oxygen to form octopamine, so-named for its discovered presence in the salivary glands of Octopus vulgaris. In the first explorations in the "OX" series, this oxygen was intentionally blocked with a methyl group, to ease its entry into the brain, and increase the possibilities of its being active as a psychedelic. As mentioned above, the "D" in "OD" follows from its ring orientation pattern being the same as that of 2C-D (and this, originally from the mimicking of the pattern of DOM). All of these D- compounds have the 2,5-dimethoxy-4-methyl ring-substitution pattern.

An interesting complication is also part of this structure package. The added methoxy group (or hydroxy group, see recipe for BOHD) also adds a new asymmetric center, allowing for the eventual separation of the material into two optical isomers. And at such time as the corresponding amphetamine homologues might be made and studied, the presence of yet another chiral center (under the alpha-methyl group) will demand that there be actually two racemic compounds synthesized, and a total of four isomers to contend with, if really careful and thorough work is to be done.

A parallel chemistry to all of this follows the addition of sodium ethoxide (rather than sodium methoxide) to the nitrostyrene. The final product, then, is the ethoxy homologue 2,5-dimethoxy-beta-ethoxy-4-methylphenethylamine, or BOED. It is down in human potency by a factor of three, with a normal dosage being 70-75 milligrams. It has a ten hour duration, and is both anorexic and diuretic. There have been no visual effects or insights reported, but rather simply a highly intoxicated state.

Two synonyms, two definitions, and an expression of admiration. The word norepinephrine is synonymous with noradrenalin, and the word epinephrine is synonymous with adrenalin. The distinctions are that the first in each case is American and the second British. And the term "chiral" indicates a potential asymmetry in a molecule that would allow eventual separation into two optical isomers. The term "racemic" refers to a mixture of these two isomers which has not yet been separated into the individual components. A racemic mixture is called a racemate and, from the point of view of the human animal (which is completely asymmetric), must be considered as a mixture of two structurally identical but optically mirror-image isomers, which can be potentially separated and which will certainly have different pharmacologies. And the admiration? This is directed to the explorer who ventured close enough to an octopus to locate its salivary glands and to discover a phenethylamine there!


Shulgin outlines how much work there is to still be done:
EXTENSIONS AND COMMENTARY: This compound, BOB, is the most potent of the BOX series. And yet, as with all of the members of this family, there are overtones of physical concern, and of some worry as to the integrity of the body. There may well be a separation of activity with the two optical isomers, but there is not a tremendous push to explore this particular family much further. They can't all be winners, I guess. What would be the activities of compounds with a sulfur instead of an oxygen at the beta-oxygen position? What would be the nature of action if there were an alpha-methyl group, making all of these into amphetamine derivatives? Or what about both a sulfur and a methyl group? And what about the isomers that are intrinsic to all of this, the threo- and the erythro- and the "D's" and the "L's"? All this is terra incognita, and must someday be looked into. It is chemically simple, and pharmacologically provocative. Someone, somewhere, someday, answer these questions! -shulgin; PIHKAL

There's still a lot of research which needs to be conducted in this area...

-eg
 
downwardsfromzero said:
entheogenic-gnosis said:
Beta-methoxy-2C-D shows great promise...

-eg
How so? Did you find anything of Ray Chamberlain's work yet?

No, I can't find anything related to Ray and psychoactives...

Ray Chamberlain is a professor of chemistry at Merritt College in Oakland, CA. He is a legitimate chemistry professor, and stated in an interview with Hamilton Morris that he never speaks with his students or publicly speaks about his work with psychoactives. Ray Chamberlain was one of the only people allowed to work in Darrell lemaire's volcano laboratory, and I'm sure his ability to keep things quite was one of the reasons. The clandestine atmosphere surrounding this work makes it somewhat difficult to research, however it's clear that Ray Chamberlain did a good deal of work regarding the BOx series and tweetio compounds.

So, why did BOD seem promising?

it's hard to say, out of the BOx series it appeared be the best candidate with the most interesting spectrum of activity, then there's the structure of the molecule, and it's relation to endogenous phenethylamine structure...

However, as shulgin mentions:

Maybe there is something to the concept that when you imitate a neurotransmitter too closely, you get a hybrid gemisch of activity. -shulgin;TIHKAL

While researching the work that Darrell lemaire and Ray Chamberlain were conducting with the BOx series, BOD jumped as out being a promising starting point. It's relation to 2C-D also made the compound noteworthy, as it is 2C-D, only with a methoxy group on the beta carbon.

BOHD was also structurally interesting, as it is 2C-D with a hydroxy group on the beta-carbon, however BOHD does not appear to be overtly psychoactive...and this did not necessarily surprise me, as I am reminded of beta-hydroxy-N-methyl-amphetamine (Pseudoephedrine) and N-methyl-amphetamine, let's look at the pharmacological differences between these compounds, one compound, beta-hydroxy-N-methyl-amphetamine is an over the counter decongestant and mild stimulant, while the other, N-methyl-amphetamine is a powerful stimulant, euphorant, and scheduled compound of abuse...a simple hydroxy group to the beta carbon facilitates these pharmocological differences...

the beta hydroxy substitution to phenethylamine compounds is familiar to the world of neurotransmitters, as 3,4-dihydroxy-phenethylamine (dopamine) becomes Norepinephrine when a methyl group is added to the beta carbon (epinephrine is identical only with an additional methyl grouping on the amine nitrogen.

Shulgin comments on BOD:
Back to the commentary on BOD. The rationale for this inclusion of a beta-oxygen atom into the structure of a phenethylamine is based directly on the chemistry that occurs naturally in the brain. The phenethylamine neurotransmitter, dopamine, is converted both in the brain and in the body to the equally important transmitter norepinephrine by just this sort of transformation. There is the enzymatic addition of an oxygen atom to the "benzylic" position of dopamine. And identical chemistry goes on with tyramine in a number of plants and animals, with a similar addition of oxygen to form octopamine, so-named for its discovered presence in the salivary glands of Octopus vulgaris. In the first explorations in the "OX" series, this oxygen was intentionally blocked with a methyl group, to ease its entry into the brain, and increase the possibilities of its being active as a psychedelic. As mentioned above, the "D" in "OD" follows from its ring orientation pattern being the same as that of 2C-D (and this, originally from the mimicking of the pattern of DOM). All of these D- compounds have the 2,5-dimethoxy-4-methyl ring-substitution pattern. -shulgin ; TIHKAL

The research continues...

However, 2,5-dimethoxy-3,4-methylenedioxy-amphetamine (and it's N-methyl-homologue), 2,5-dimethoxy-4-methyl-phenethylamine, 2,5-dimethoxy-3,4-dimethyl-phenethylamine/amphetamine, and a few select tryptamine and lysergamide molecules have been the focus of my recent research.

I would have much more to say if I were allowed to discuss synthesis...

-eg
 
spacexplorer said:
Wait, so if you take Salicinium, you have an 85% chance of surviving any type of cancer?

I think it was saying 85% of those treated survived, not that it would give you an 85% chance of surviving...

In 2005, Joe Brown and Forrest Niccum hired Lemaire to help them with investigating the potential medicinal applications for some phytochemicals. Together they discovered that salicinium—a glucoside of 4-hydroxy-benzaldehyde, extracted from the plant Helicia nilagirica—shows great promise as a cancer treatment, with a survival rate in Stage 4 cancer patients of nearly 85%.

-eg
 
entheogenic-gnosis said:
spacexplorer said:
Wait, so if you take Salicinium, you have an 85% chance of surviving any type of cancer?

I think it was saying 85% of those treated survived, not that it would give you an 85% chance of surviving...

In 2005, Joe Brown and Forrest Niccum hired Lemaire to help them with investigating the potential medicinal applications for some phytochemicals. Together they discovered that salicinium—a glucoside of 4-hydroxy-benzaldehyde, extracted from the plant Helicia nilagirica—shows great promise as a cancer treatment, with a survival rate in Stage 4 cancer patients of nearly 85%.

-eg

So what was the survival rate before it became 85% I wonder...?
 
spacexplorer said:
entheogenic-gnosis said:
spacexplorer said:
Wait, so if you take Salicinium, you have an 85% chance of surviving any type of cancer?

I think it was saying 85% of those treated survived, not that it would give you an 85% chance of surviving...

In 2005, Joe Brown and Forrest Niccum hired Lemaire to help them with investigating the potential medicinal applications for some phytochemicals. Together they discovered that salicinium—a glucoside of 4-hydroxy-benzaldehyde, extracted from the plant Helicia nilagirica—shows great promise as a cancer treatment, with a survival rate in Stage 4 cancer patients of nearly 85%.

-eg

So what was the survival rate before it became 85% I wonder...?

I know that the 5 year survival rate for stage 4 lung cancer is somewhere around 4% with current treatments, though I'm not sure what cancer type was being investigated. The survival rate would be different depending on the type of cancer.

 
Infusion Treatment Methods And Compositions Using Salicinium For Treating Cellular Proliferative Disorders And Immune Deficiencies
US 20110311477 A1
ABSTRACT
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anaerobic and cellular proliferative disorders including cancer. The immunotherapeutics herein use benzaldehyde derivatives, precursors and intermediaries alone or in combination with additional therapeutic agents to stimulate the immune system and inhibit cellular proliferation. The immunotherapeutics of the present invention are particularly useful in the treatment of microbial infections and cellular proliferative disorders which are resistant to traditional methods of treatment such as antibiotics and chemotherapy

You can review all the research HERE this patent is held by Brown, who lemaire was hired to help.

In 2005, Joe Brown and Forrest Niccum hired Lemaire to help them with investigating the potential medicinal applications for some phytochemicals. Together they discovered that salicinium—a glucoside of 4-hydroxy-benzaldehyde, extracted from the plant Helicia nilagirica—shows great promise as a cancer treatment, with a survival rate in Stage 4 cancer patients of nearly 85%.

-eg
 
Going off the topic of Using Salicinium For Treating various conditions, but staying on the topic of Darrell lemaire and his publications:
(Though I'm still very interested in the discussion at hand, and am not trying to divert from it, I am simply interjecting related information into the thread)


Found an old paper published by shulgin and lemaire regarding BOx series compounds...still can't dig up anything regarding Ray Chamberlain and the chemistry of novel phenethylamines, though it's known that he worked on beta-methoxy and beta-hydroxy substituted phenethylamines with lemaire...

Lemaire D, Jacob P, Shulgin AT.
“Ring-substituted beta-methoxyphenethylamines: a new class of psychotomimetic agents active in man”.
J Pharm Pharmacol. 1985 Aug 25;37 (8 ):575-7.

Abstract
Four members of a new class of psychotomimetic agents have been synthesized and evaluated in man. These compounds, which incorporate a beta-methoxy group onto a beta-phenethylamine sidechain, are the first reported psychotomimetics which are structural analogues of the neurotransmitter noradrenaline. These substances are more potent than the corresponding phenethylamines (lacking a beta-methoxy group) but less potent than the correspondingly substituted amphetamine derivatives.

Here is a previously posted excerpt from PIHKAL which seemed to relate to the published paper above:

The rationale for this inclusion of a beta-oxygen atom into the structure of a phenethylamine is based directly on the chemistry that occurs naturally in the brain. The phenethylamine neurotransmitter, dopamine, is converted both in the brain and in the body to the equally important transmitter norepinephrine by just this sort of transformation. There is the enzymatic addition of an oxygen atom to the "benzylic" position of dopamine. And identical chemistry goes on with tyramine in a number of plants and animals, with a similar addition of oxygen to form octopamine, so-named for its discovered presence in the salivary glands of Octopus vulgaris. In the first explorations in the "OX" series, this oxygen was intentionally blocked with a methyl group, to ease its entry into the brain, and increase the possibilities of its being active as a psychedelic. As mentioned above, the "D" in "OD" follows from its ring orientation pattern being the same as that of 2C-D (and this, originally from the mimicking of the pattern of DOM). All of these D- compounds have the 2,5-dimethoxy-4-methyl ring-substitution pattern. -shulgin ; TIHKAL

------

Misc. Lemaire publication

PDF
"Notes About Psychoactive Compounds" [darrell lemaire as Hosteen Nez]. In J. Millay (Ed.) Radiant Minds: Scientists Explore the Dimensions of Consciousness(2010)

The above was pretty interesting stuff, a good read, in general it's a story, though there is plant psychoactive and chemical information sprinkled throughout the text, many of the compounds discussed briefly in "smart pills" are also mentioned here. It's short, but valuable, a welcome addition to my collection.

------

-eg
 
2CE-5EtO
4-Ethyl-5-Ethoxy-2-Methoxyphenethylamine

This was the only compound of the 2CE series evaluated for smart pill activity. It was found to be like its 5-Ethoxy counterpart of the 2CT2 series to be very long acting, about 24 hours with little or no sleep possible without Halcion. Dosages ranged from 5 to 16 mg and it generally took about two hours for the material to become effective after ingestion. In one test three subjects took the material together and read an entire book of over 300 pages, taking turns reading aloud. The following day after a little sleep, they discussed the content of the book and found that they could quote entire paragraphs and their understanding and retention was excellent. All three were quite impressed with the entire test. The feeling was that this would be good for brain-storming or other similar small group activities. They also felt that the material could manifest philosophical overtones during the time the material was active

These diethoxy homologues of known novel phenethylamines fascinate me...

2CT2-DiEt
2,5-Diethoxy-4-Ethylthiophenethylamine (6)

This was tested at levels of from 5 to 15 mg. The effects lasted for only three hours and users reported that reading was very easy with good concentration and assimilation. The three thio compounds listed above were the only ones checked for smart pill activity. LAZAR feels that the manipulations with ring substituents on a dozen or more other thio compounds could be most interesting and rewarding. The reason more work was not done in this area was the passage of the "Controlled Substances Analog Bill".

The reason more work was not done in this area was the passage of the "Controlled Substances Analog Bill".

This must be why lemaire chose Casey hardison...

Lemaire stated in "smart pills"
It was difficult to get the people involved with these tests to make written reports of what they experienced with the compound. -lazar lemaire

Casey did a large survey involving 2c-t-7 (referenced below)

Sulfurous Samadhi
Casey Hardison's Survey
by Murple, Feb 6, 2001

As mentioned previously, Casey Hardison, a graduate student at the University of Idaho, conducted an informal survey of 2C-T-7 users at the Entheobotany conference in Palenque, Mexico in February 2000. Noticing that quite a few people were conducting bioassays of the material, Hardison seized the opportunity to perform some informal impromptu research. He designed a survey which was handed out to conference attendees, and received 48 responses. The results of this survey were published in the Summer 2000 issue of the MAPS Bulletin under the title "An Amateur Qualitative Study of 48 2C-T-7 Subjective Bioassays."

After the survey was published by MAPS, it caught the attention of lemaire, who in turn reached out to Casey, donating lab equipment and support...

I can't help but think that lemaire saw a person with the knowledge and skill to produce these novel compounds, who also had the drive and abilities to conduct "shulgin" style research with these compounds...

I can't say lemaire failed, as Casey is a vocal figure for psychoactive rights, who has earned his place in psychedelic history, however, part of me thinks lemaire wanted this research to be carried on, particularly in the fashion in which lemaire and shulgin would have been familiar with, I feel he would have wanted to see more books like PIHKAL and "smart pills" being released regarding all the compounds he was never able to research in this manner...

...I think there will always be a trained chemist with the love of these compounds who will conduct professional grade research within unsanctioned settings, using willing research groups, synthesizing their own molecules and publishing the information...

When I first got into chemistry, I simply wanted to synthesize psychedelic drugs, to be handed out (for free) to any adult who wanted to explore them, now I have reached more informed conclusions...
In the 1960s, we thought that all that had to happen was - everybody would take LSD and the obvious right things to do would be done. We expected no opposition to this because it’s rightness was so obvious. We didn’t realize that every righteous crusade in history has marched into the waiting jaws of its oppressors. -terence McKenna

-eg
 
2-methoxy-5-ethoxy-4-ethyl-phenethylamine has been of particular interest recently, below is an excerpt from Darrell lemaire's "smart pills" pamphlet:

2CE-5EtO
4-Ethyl-5-Ethoxy-2-Methoxyphenethylamine

This was the only compound of the 2CE series evaluated for smart pill activity. It was found to be like its 5-Ethoxy counterpart of the 2CT2 series to be very long acting, about 24 hours with little or no sleep possible without Halcion. Dosages ranged from 5 to 16 mg and it generally took about two hours for the material to become effective after ingestion. In one test three subjects took the material together and read an entire book of over 300 pages, taking turns reading aloud. The following day after a little sleep, they discussed the content of the book and found that they could quote entire paragraphs and their understanding and retention was excellent. All three were quite impressed with the entire test. The feeling was that this would be good for brain-storming or other similar small group activities. They also felt that the material could manifest philosophical overtones during the time the material was active.

-eg
 
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