Changa and amitriptyline ?

[omega-scar]

Hello. I've got my hands on some Changa from a friend. I have previously smoked freebase DMT but never done Changa and I'm on a fairly high dose of amitriptiline (150 mg) which I must say is working great. I've been taking it for a few years now. So the problem is I feel very tempted to try Changa but stopping my antidepressant is a pretty lengthy process since it clears away very slowly so I would need first to tapper it for a few weeks and then stop it for another 2 weeks in order to clear it from my system. I am very tempted tp try to do Changa on top of it. What do you guys (and gals ) think ?

 

[Pumpy]

I've heard that you can't trip on ssri s, so i think you might regret wasting the changa.

 

[Varallo]

Combining amitriptyline with harmala alkaloids (such as those from Peganum harmala or Banisteriopsis caapi) is potentially dangerous, do not use your Changa unless absolutely certain that what you actually have is exchanged leave (without harmalas) and not Changa (with harmalas).

 

[omega-scar]

Combining amitriptyline with harmala alkaloids (such as those from Peganum harmala or Banisteriopsis caapi) is potentially dangerous, do not use your Changa unless absolutely certain that what you actually have is exchanged leave (without harmalas) and not Changa (with harmalas).

Hi. Thanks for taking your time to answer. Is there a practical way to find out if what I actually have is exchanged leave ? Can you clarify a bit what you mean by 'exchanged leave' ?

 

[redbird]

Hi. Thanks for taking your time to answer. Is there a practical way to find out if what I actually have is exchanged leave ? Can you clarify a bit what you mean by 'exchanged leave' ?

He meant enhanced leaf, aka herbs with only dmt added.
Point being consuming any harmalas/maois with amiltriptyline still in your system could have severely negative consequences, potentially including death.
Don't risk it.
To Varallo's point, only proceed if you made the changa and know that it's just dmt on herbs with no harmalas added or maoi containing herbs (for example but not exhaustive: caapi leaves) in the blend.

 

[redbird]

Also, I would not quit your seemingly effective medication just to smoke changa. Instead, work with your provider to develop an end game strategy.
Having been on all types of antidepressants in my life, I understand how helpful they can be. I also know that they aren't a true solution. They tend to just make you feel okay about your problems instead of making you feel confident enough to solve them. If you want to get off antidepressants, that's not a bad idea.
My strongly held but personal opinion about those drugs is that they should not be used longer than necessary to stabilize a crisis and allow for more sustainable, non-pharmaceutical interventions to take effect.
If your provider intends to keep you on medication for the entirety of the time you are under their care, my opinion is that you should stay on your medication while you look for other providers willing to explore other long term options.

 

[2^DqoeHy*97u]

Surely combining DMT with Amitriptyline is dangerous anyway, so the enhanced leaf isn't a safe bet either?
After a decades long gap I got round to DMT again recently, started with just a few grains and working up a tiny bit at a time, but experienced no visual effects at all. Got up as far as 60mg and tripping hard but no shiny colours or shapes. Only then did I start reading properly and realise that the Amitriptyline I take doesn't make a good combination.
I take it for pain relief so no issues with cutting back, I started tapering down just out of curiosity to see what difference it would make to a DMT trip. Cut from 100mg to 50mg over the period of a month then decided to try again with a very small amount of DMT, I reckon less than 20mg. This time the whole DMT madness at full scale, so I can certainly say that in my case the Amitriptyline above a certain dose appears to kill the trip as well as making an unhealthy combination.
Looking forward to completely clearing my system and enjoying the DMT at full strength.

 

[Varallo]

Surely combining DMT with Amitriptyline is dangerous anyway

Do you have a source for this claim or is this based off your personal experience?

far as 60mg and tripping hard but no shiny colours or shapes.

Be careful 25 mg is usually enough for an breakthrough.

Amitriptyline above a certain dose appears to kill the trip as well as making an unhealthy combination.

I’m not sure unhealthy is the right word, the warning in this thread is about the combination with harmalas.

then decided to try again with a very small amount of DMT, I reckon less than 20mg.

Be careful with estimates on dose, use a scale to prevent over doing it.

 

[2^DqoeHy*97u]

Do you have a source for this claim or is this based off your personal experience?

Be careful 25 mg is usually enough for an breakthrough.

I’m not sure unhealthy is the right word, the warning in this thread is about the combination with harmalas.

Be careful with estimates on dose, use a scale to prevent over doing it.

As for the first, I went by this, which is what google tells me:

Combining dimethyltryptamine (DMT) and amitriptyline is dangerous and should be strictly avoided due to a high risk of adverse events, including serotonin syndrome and severe central nervous system (CNS) depression.

• Amitriptyline is a prescription tricyclic antidepressant (TCA) used to treat depression, neuropathic pain, fibromyalgia, and migraine prevention. It works by increasing levels of serotonin and norepinephrine in the brain.
• DMT (N,N-dimethyltryptamine) is a potent, naturally occurring psychedelic compound and a Schedule I controlled substance in the United States. It acts primarily as a partial agonist of various serotonin receptors.

Risks of the Combination
Mixing these two substances can lead to life-threatening interactions:

• Serotonin Syndrome: Both amitriptyline and DMT increase serotonin activity. Combining them can cause a dangerous excess of serotonin in the brain, leading to symptoms like confusion, muscle twitching, rapid heartbeat, excessive sweating, shivering, and fever.
• Central Nervous System (CNS) Depression: Amitriptyline has sedative effects, and combining it with other CNS depressants can intensify this effect, leading to extreme drowsiness, lack of coordination, respiratory depression, and potentially coma.
• Cardiovascular Issues: Both drugs can affect heart rate and rhythm, increasing the risk of arrhythmias, dangerously low blood pressure (orthostatic hypotension), and even cardiac arrest.

As for the others I'd used a milligram scale all the way from almost nothing up to 60mg. I'd read already that 60 was a lot but since my path there was spread over I'd say probably 20 tries, each a small increase from the last, I figured that if I'd experienced nothing of concern from 40, 45, 50, then 60 wouldn't be that much more. I've taken similar amounts in the past. I made it myself using the most discussed A/B method so obviously can't guarantee strength. It looks just like the pictures though and did work at the later stage. By this point I've done sufficient trials that I can eyeball small amounts without worry 20mg near enough. Like I said I'm not new to this and know pretty much what to expect.

Yes I'm aware that this thread is about harmalas, but I was replying to the posts which suggested checking to see if it didn't contain any, which implies that way is ok.

 

[Varallo]

Thanks for the clarification, I’m guessing (let me know if I’m wrong) that this was generated by Google. For reference DMT is a 5-HT2A partial agonist, not a serotonin releaser or reuptake inhibitor, so while it’s not impossible it’s improbable that this is an issue, I mean we are combining DMT with harmalas very regularly without having much problems.

 

[2^DqoeHy*97u]

Thanks for the clarification, I’m guessing (let me know if I’m wrong) that this was generated by Google. For reference DMT is a 5-HT2A partial agonist, not a serotonin releaser or reuptake inhibitor, so while it’s not impossible it’s improbable that this is an issue, I mean we are combining DMT with harmalas very regularly without having much problems.

At which point the chemistry leaves me behind. In fact I think I'm going to potentially contradict my earlier google generated response by using a Wikipedia one, which says that amitriptyline is a 5-HT2A antagonist - that means blocker does it? Perhaps that's related to the perceived problem.
Either way since the chemistry is beyond me I'll stick to my approach. But. I'm sorry if there are untruths in my original post, they were made in good faith. I'd hate to think that an error of mine could potentially negatively impact on anyone else's experience though, hopefully they'll read this far.
If that's not good enough either let me know and I'll change it, or help yourself if that's easier.