I see where youre coming from with that global. Im not saying the color actually changes the structure of the crystal, but rather adds to the "fine tuning" of a particular kind. Agate is agate whether it is blue, red, etc... Quartz is quartz whether its clear, rose, smoky.... The extra compounds/elements within that stone ever so slightly adjusts its "frequency". As for giving the "scientific evidence" I can offer very little. I do crystal work with less "knowledge" than I do "understanding". Take that statement as you will. I am self taught from personal research. And I should note that I use them almost strictly in a metaphysical way, I do not collect gems as decoration.
The most effective way to use a crystal/stone is to keep near a "pulsepoint" on ones body or the chest for hours at a time. Specifically the wrists(namely inside), ankles, neck, and ears. This is WAY more effective than carrying them around in ones pocket.
If you have a particularly large clear quartz crystal, I have a meditation technique to share should any be interested in trying it. It blew my mind when I did it...
Is your crystal cleared, purposed, and charged? One can find many methods to these on the net but here is a very basic rundown on how I do it.
CLEAR- find a safe place to leave it in the sun from rise to set, one day will do well to clear any previous charges/purposed depending on size and that particular ones "strength"
PURPOSE- hold your crystal in your dominant hand. Focus on the crystal and what you are purposing it for. I set mine to attract love and understanding. WILL the crystal to hold that purpose. Focus but do not concentrate, many of are very familiar with what that means. Shouldnt take but 60 seconds or so.
CHARGE- there are also many ways to do this... The most effective for me has been to hold it to my chest with both hands, right hand on the crystal, left on right, and to focus on giving/sharing my energy to/with it. I accompany this with om chanting. I feel it helps, just preference. About 5 minutes.
The Meditation- Audio stimulation helps alot for me, soothing music, maybe just running water in my environment, whatever works for calm, obviously. Lay down and get comfortable. Place the crystal directly on your chest "centered" over your green chakra. Here is the fun part:
1-Feel out your chakra. You should be able find a "flowing" of energy a few inches below the surface. Get aquainted with that energy. To me it feels like a odd "heaviness" within.
2-Slowly move your focus from this energy to where you can feel the crystal sitting on your chest, pull that "energy" with your focus. At this point the crystal begins to feel like it is becoming lighter, almost as if I am melding with it, becoming the same as.
3-Once you do not "feel" the weight of the crystal any more, slowly move your focus inside the crystal. Once there, ENJOY!
The first time I had a "breakthrough" it was during this meditation. I used it to find my way to the "door to hyperspace". I havent been very far inside but holy smokes was I surprised to see what I did when I "opened" it.
to continue my answer to global:
I am heavily into the metaphysical, my reason for coming to the nexus was partly to find the scientific echos of what I feel/believe.