"It is the very essence of depression to make the sufferer's own, private world appear gloomy and uninhabitable. Sure, there are degrees of suffering, and it's better to be healthy, rich and depressed than sick, poor, and depressed. However, imagery of birds chirping joyfully and blue summer skies is not likely to dissipate a depressed person's inner turmoil.
I see psychedelics as a double-edge sword. At first, it's certainly nice to become aware of these other dimensions, whatever your own interpretation of the hyperspace may be. However, there's a possibility here that the explorer will become less invested in the more conventional reality, even more so if you're already not satisfied with the said reality (as your eggs aren't all in one basket anymore).
Now it's probably safe to assume that most of those who go chasing rabbits are a bit off-center to begin with. However, if you just use the drug to facilitate your escapist tendencies, then that's where the benefits end, and it's not all that different if you're taking psychedelics, doing other drugs, or watching reality shows all day.
The importance of integrating the psychedelic experience has been often emphasized on this forum, and I think that's a topic you may want to explore if you are interested in the therapeutic potential of psychedelics. When discussing his journey towards personal growth, someone on yogaforums said that, once he passed a certain milestone, the bills were still there, but the longing was gone. I think that if your psychedelic experiences help you come back to your everyday life and be there, be present (instead of getting stuck in the loop, building theories about the ultimate truth etc), the journey was well worth it. "
I believe that much of my depression comes from loosing my beliefs in anything but this physical world, which is pretty much messed up, so even experiencing another dimesnion would be of help to me, I think. I never tried to escape this world, in any way, I just want to get in contact with new insights, so that I could change some of the beliefs at the root of my depression.