Stability study of the designer drugs "MDA, MDMA and MDEA" in water, serum, whole blood, and urine under various storage temperatures.
Clauwaert KM1, Van Bocxlaer JF, De Leenheer AP.
Abstract
A controlled study was undertaken to determine the stability of the designer drugs MDA, MDMA and MDEA in pooled serum, whole blood, water and urine samples over a period of 21 weeks. The concentrations of the individual designer drugs in the various matrices were monitored over time, in the dark at various temperatures (-20, 4 or 20 degrees C), for a low (+/- 6 ng/ml for water, serum and whole blood and +/- 150 ng/ml for urine) and a high concentration level (+/- 550 ng/ml for water, serum and whole blood and +/- 2500 ng/ml for urine). Compound concentrations were measured using a validated HPLC assay with fluorescence detection. Our study demonstrated no significant loss of the designer drugs in water and urine at any of the investigated temperatures for 21 weeks. The same results were observed in serum for up to 17 weeks, and up to 5 weeks in whole blood. After that time, the compounds could no longer be analyzed due to matrix degradation, especially in the low concentration samples that were stored at room temperature. This study demonstrates that the designer drugs, MDA, MDMA and MDEA are stable when stored at -20 degrees C for 21 weeks, even in haemolysed whole blood.
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Stability study of the designer drugs "MDA, MDMA and MDEA" in water, serum, whole blood, and urine under various storage temperatures - PubMed
A controlled study was undertaken to determine the stability of the designer drugs MDA, MDMA and MDEA in pooled serum, whole blood, water and urine samples over a period of 21 weeks. The concentrations of the individual designer drugs in the various matrices were monitored over time, in the dark...www.ncbi.nlm.nih.gov
Peyote alkaloids: identification in a prehistoric specimen of lophophora from coahuila, Mexico
Abstract
Mescaline, anhalonine, lophophorine, pellotine, and anhalonidine have been identified in alkaloid extracts of a prehistoric specimen of Lophophora from a burial cave in west central Coahuila, Mexico. The specimen is associated with radiocarbon dates of A.D. 810 to 1070 and is one of the oldest materials ever submitted to alkaloid analysis.
Peyote alkaloids: identification in a prehistoric specimen of lophophora from coahuila, Mexico - PubMed
Nathanial.Dread said:I'd worry about that methylene dioxy ring falling apart though. It's stabilized by the adjacent aromatic structure, but looking at it, I'd expect that it would probably fall apart into ortho hydroxyl and methoxy groups, esp. if exposed to heat or ambient moisture.
Whether the resulting compound is active or toxic, I have no idea. That hydroxyl group would probably inhibit crossing of the BBB though.
Blessings
~ND
4-methoxy-N-methyl-amphetamine (with 110 mg) One hour into it, my pulse was up over 100, and I was compulsively yawning. There was some eye muscle disturbance, a little like the physical side of MDMA, but there was none of its central effects. But all the hints of the cardiovascular are there. By the fourth hour, I am pretty much back to baseline, but the yawning is still very much part of it. I might repeat this, at the same level, but with continuous close monitoring of the body. PIHKAL ; shulgin
MDMA metabolism is rather complex and includes 2 main metabolic pathways: (1) O-demethylenation followed by catechol-O-methyltransferase (COMT)-catalyzed methylation and/or glucuronide/sulfate conjugation; and (2) N-dealkylation, deamination, and oxidation to the corresponding benzoic acid derivatives conjugated with glycine.
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Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition - PubMed
MDMA (3,4-methylenedioxymethamphetamine, ecstasy) is a widely misused psychostimulant drug abused among large segments of the young population. Pharmacologically it displays effects related to amphetamine-type drugs and a set of distinctive effects (closeness to others, facilitation to...www.ncbi.nlm.nih.gov
That would require strongly acidic or strongly alkaline conditions, not those encountered in the neutral crystalline material.I'd worry about that methylene dioxy ring falling apart
Especially when the stuff has been stored in the freezer for three years. Yes, it's safe.endlessness said:A lot of theory here and you guys are the real chemists not me...
But in practice, MDMA is very stable, ive tested samples that were years old stored just in a drawer and there was not a hint of degradation.
Orbitals are for mathematicians – Organic chemistry is for people who like to cook ! -Alexander shulgin
endlessness said:extremely stable... it could have been two decades and it would be fine to consume![]()
dragonrider said:Especially when the stuff has been stored in the freezer for three years. Yes, it's safe.endlessness said:A lot of theory here and you guys are the real chemists not me...
But in practice, MDMA is very stable, ive tested samples that were years old stored just in a drawer and there was not a hint of degradation.