I've done the mushrooms with rue or vine combo a lot of times. I've got dozens of good experiences and only one bad experience.
To begin with the bad experience: i felt very sweaty and cold then, and it felt like i had ingested some kind of poison. There was also some nausea and an aching stomach and liver then.
It is possible that these mushrooms contained some kind of toxin that would normally be neutralised by MAO, but given the fact that, of a few dozen times doing the combo, this happened only once, i think that the presence of such a toxin is rather rare.
The many good experiences i've had then: It's not that much different from 'normal ayahuasca', with psychotria viridis, acacia or mimosa hostilis. But, it's definately more euphoric. It feels very energetic. Where shrooms alone, without MAOI's, normally give me a sort of dispassionate kind of feeling, the presence of MAOI's totally change that. With MAOI's i feel a lot of passion. The beauty of the Visuals, the beauty of the whole experience realy, it realy touches me then. It's more alive, more vibrant....When it works well, it just tends to work very well.
For me, it's like the difference between TV and IMAX. I find shrooms by themselves to be somewhat cold. Interesting from an intellectual point of view, but not realy doing much personally or spiritually. Caapi or rue change all of that. I think it's the dopamine.