digitalvygr
Rising Star
60 years of scientific papers on endogenous DMT make it a virtual certainty that it is produced in the human body... Pinoline has also been found, though the exact endogenous chemistry is less well understood.
The main questions now are:
1. Where is it produced?
2. When/under what (special) circumstances is it produced?
3. How much is produced?
and
4. Based on the above and noted subjective effects, what actions, supplements, etc. can be taken to promote higher levels of endogenous DMT, either for a "microdosed" level, or possibly even for large release and natural trips.
1. A lot of spirited discussion goes on about number 1 here. For my research, and based on recent commentary from Rick Strassman, the most likely answer is that it is *primarily* produced in the lungs (which is also where INMT seems to be most expressed), but that the pineal gland might also be an area of secondary production given the unique substrates and enzymes found there. It seems like 5MeODMT is most likely made there, and it has also been found in the human body. CSF seems to be the highest concentrations found for all these substances.
The discovery of DMT in the rat pineal is promising, but does not prove it was made there. The CSF (Cerebro Spinal Fluid) contains INMT and DMT, and the pineal is bathed in the CSF. This means that DMT could simply accumulate in the pineal because of the CSF, or that INMT could reach there and help it be produced there, etc.
2. Studies on the When are lacking... we can speak of this in many ways...
For example, what time of day is it more likely to find these substances in the human body? An educated guess would be towards the end of the night given breathing patterns of sleep and related compound production of things like melatonin, but again, studies are lacking.
Also, extreme stress is theorized to produce DMT, and indeed the pineal is signaled by Norepinephrine... however stress hormones produced in the adrenals basically never get to the pineal, so here we are talking about a unique kind of stress signal, possibly from the same nerve cells that usually only signal the pineal to produce melatonin using norepinephrine, or possibly some other signal. Or possibly just from the lungs under stress, etc. Here again studies are obviously lacking for ethical reasons, so we have mostly speculation.
DMT has been found to be extremely potent for protecting nerve cells against lack of oxygen, so the stress signals due to lack of oxygen in cardiac arrest and drowning, etc. might be an evolutionary adaptive signal that would cause the release of DMT somehow in order to protect the brain. Anecdotally, this would also correlate with the relatively high rate of DMT-like near death experiences, especially in cardiac arrest cases.
In Pranayama and the Wim Hof methods of breathing, practitioners regularly report DMT like experiences. The Dreamer himself has had profound visionary experiences from Pranayama, and from Wim Hof the Dreamer has also experienced a sharpness of daily vision, especially with regard to plants and an emphasis of their underlying fractal nature that is suggestive of something like an endogenous micro-dose.
Meditative states are also reported to bring about strong visual states. Searches for the videos by Jurgen Ziewe of his 4D fractal experiences from mediation/OBEs are one such anecdotal example that indicates the possibility of endogenous DMT release in relatively large quantities.
The Dreamer himself has also had multiple OBEs that lead to 4D realms filled with fractals and mandalas, and on some occasions, other autonomous entites. The Dreamer has also correlated multiple somatic and visual experiences of his OBEs with Strassman's recordings from the experiments and UNM, and has the agreement of Strassman himself that there is a possibility that endogenous DMT is mediating them. The Dreamer compares direct experience of smoalked DMT and notes somewhat less intensity but also amazing similarities to his deepest, most powerful OBEs.
3. How Much - the gut reaction is to say that is can be nowhere near as much as a smoalked session... however, given the half life of DMT in the blood, and how it is so quickly and ravenously scavenged by MAO and other metabolic processes, it is rather amazing to think that it is found at all in bodily fluids of average people. It is suggestive of either large amounts being produced in sleep states, or constant small amounts being produces on a more regular basis (perhaps DMT is part of waking consciousness).
And as various chemistries are examined, there could be "runaway endogenous production" scenarios.
For example, the pineal has all the chemistry necessary to produce at least both pinoline and 5MeODMT, and adding in INMT if from nowhere else but the CSF, also DMT.
Now pinoline is BOTH an MAO AND a serotonin re-uptake inhibitor. So it could keep normal DMT around much longer. And it would cascade the production of serotonin, which in the pienal is already the highest density anywhere in the body. Again, the chemistry is all there to make 5MeO from the serotonin, so in this scenario you could have a possible bonfire production going on.
The point is that if we intelligently discuss the chemistry and known facts, maybe we can stumble on some ways to potentiate the WHEN-WHERE-HOW MUCH aspects of this proven endogenous production.
It would seem that yogis have done this to some extent... Pranayama and things like Kechari Mudra are examples. And the Tibetans with their Dream Yoga have reported things like "DMT is as far as you can go in the Bardo without actually dying..."
Well, I say here at the Nexus are assembled some of the best minds on the planet, and with the most experience of the direct substance, and if we can all just put aside some differences and speak open mindedly about the "what ifs", then we here can also advance this knowledge :thumb_up:
The main questions now are:
1. Where is it produced?
2. When/under what (special) circumstances is it produced?
3. How much is produced?
and
4. Based on the above and noted subjective effects, what actions, supplements, etc. can be taken to promote higher levels of endogenous DMT, either for a "microdosed" level, or possibly even for large release and natural trips.
1. A lot of spirited discussion goes on about number 1 here. For my research, and based on recent commentary from Rick Strassman, the most likely answer is that it is *primarily* produced in the lungs (which is also where INMT seems to be most expressed), but that the pineal gland might also be an area of secondary production given the unique substrates and enzymes found there. It seems like 5MeODMT is most likely made there, and it has also been found in the human body. CSF seems to be the highest concentrations found for all these substances.
The discovery of DMT in the rat pineal is promising, but does not prove it was made there. The CSF (Cerebro Spinal Fluid) contains INMT and DMT, and the pineal is bathed in the CSF. This means that DMT could simply accumulate in the pineal because of the CSF, or that INMT could reach there and help it be produced there, etc.
2. Studies on the When are lacking... we can speak of this in many ways...
For example, what time of day is it more likely to find these substances in the human body? An educated guess would be towards the end of the night given breathing patterns of sleep and related compound production of things like melatonin, but again, studies are lacking.
Also, extreme stress is theorized to produce DMT, and indeed the pineal is signaled by Norepinephrine... however stress hormones produced in the adrenals basically never get to the pineal, so here we are talking about a unique kind of stress signal, possibly from the same nerve cells that usually only signal the pineal to produce melatonin using norepinephrine, or possibly some other signal. Or possibly just from the lungs under stress, etc. Here again studies are obviously lacking for ethical reasons, so we have mostly speculation.
DMT has been found to be extremely potent for protecting nerve cells against lack of oxygen, so the stress signals due to lack of oxygen in cardiac arrest and drowning, etc. might be an evolutionary adaptive signal that would cause the release of DMT somehow in order to protect the brain. Anecdotally, this would also correlate with the relatively high rate of DMT-like near death experiences, especially in cardiac arrest cases.
In Pranayama and the Wim Hof methods of breathing, practitioners regularly report DMT like experiences. The Dreamer himself has had profound visionary experiences from Pranayama, and from Wim Hof the Dreamer has also experienced a sharpness of daily vision, especially with regard to plants and an emphasis of their underlying fractal nature that is suggestive of something like an endogenous micro-dose.
Meditative states are also reported to bring about strong visual states. Searches for the videos by Jurgen Ziewe of his 4D fractal experiences from mediation/OBEs are one such anecdotal example that indicates the possibility of endogenous DMT release in relatively large quantities.
The Dreamer himself has also had multiple OBEs that lead to 4D realms filled with fractals and mandalas, and on some occasions, other autonomous entites. The Dreamer has also correlated multiple somatic and visual experiences of his OBEs with Strassman's recordings from the experiments and UNM, and has the agreement of Strassman himself that there is a possibility that endogenous DMT is mediating them. The Dreamer compares direct experience of smoalked DMT and notes somewhat less intensity but also amazing similarities to his deepest, most powerful OBEs.
3. How Much - the gut reaction is to say that is can be nowhere near as much as a smoalked session... however, given the half life of DMT in the blood, and how it is so quickly and ravenously scavenged by MAO and other metabolic processes, it is rather amazing to think that it is found at all in bodily fluids of average people. It is suggestive of either large amounts being produced in sleep states, or constant small amounts being produces on a more regular basis (perhaps DMT is part of waking consciousness).
And as various chemistries are examined, there could be "runaway endogenous production" scenarios.
For example, the pineal has all the chemistry necessary to produce at least both pinoline and 5MeODMT, and adding in INMT if from nowhere else but the CSF, also DMT.
Now pinoline is BOTH an MAO AND a serotonin re-uptake inhibitor. So it could keep normal DMT around much longer. And it would cascade the production of serotonin, which in the pienal is already the highest density anywhere in the body. Again, the chemistry is all there to make 5MeO from the serotonin, so in this scenario you could have a possible bonfire production going on.
The point is that if we intelligently discuss the chemistry and known facts, maybe we can stumble on some ways to potentiate the WHEN-WHERE-HOW MUCH aspects of this proven endogenous production.
It would seem that yogis have done this to some extent... Pranayama and things like Kechari Mudra are examples. And the Tibetans with their Dream Yoga have reported things like "DMT is as far as you can go in the Bardo without actually dying..."
Well, I say here at the Nexus are assembled some of the best minds on the planet, and with the most experience of the direct substance, and if we can all just put aside some differences and speak open mindedly about the "what ifs", then we here can also advance this knowledge :thumb_up:
