Perhaps with changa but it wouldn't be very effective with enhanced leaf alone. Also, DMT joints are not the wisest way to smoke DMT because you could drop it when it starts hitting hard and burn yourself or set something on fire. So, technically yes, it would work but...
There is a small window in which one needs to get the effective DMT dose into their system. Having an MAOI present increases this window hence why a changa joint would be more appropriate. However, I wouldn't recommend doing it this way. Smoke the enhanced leaf or changa out of a bong. It is easy and very effective.