• Members of the previous forum can retrieve their temporary password here, (login and check your PM).

Extracting 5-MeO-DMT

Migrated topic.
S

SpasticSpaz

Rising Star
Has anyone successfully extracted 5-MeO-DMT from plant sources? Perhaps V. Theiodora resin?

The 69Ron's sublingual method with resin was never successful for SWIM, but he happened on some synthetic 5-MeO-DMT and the smoked experience was an utter revelation (that might just be the understatement of this millennium).

However, he's uncomfortable with the shadiness associated with synthetic drugs, not to mention the fact that the DEA's plans to make it illegal would make that route untenable even if he was comfortable with it, so he'd like to be able to extract it in the comfort of his own home.
 
SpasticSpaz said:
Has anyone successfully extracted 5-MeO-DMT from plant sources? Perhaps V. Theiodora resin?
The 69Ron's sublingual method with resin was never successful for SWIM, but he happened on some synthetic 5-MeO-DMT and the smoked experience was an utter revelation (that might just be the understatement of this millennium).

However, he's uncomfortable with the shadiness associated with synthetic drugs, not to mention the fact that the DEA's plans to make it illegal would make that route untenable even if he was comfortable with it, so he'd like to be able to extract it in the comfort of his own home.
Click to expand...

How about getting a pet Sonoran Desert Toad? Its venom is ~15% 5-Meo-DMT by weight, apparently you can smoke it as is. I haven't heard of possible extractions from that though.
 
I would try a simple A/B on virola resin.

according to this: The pKa and XlogP values of DMT, 5-MeO-DMT, 5-HO-DMT, and related compounds - DMT Discussion - Welcome to the DMT-Nexus

xlogp of 5-meo is nearly the same as dmt, so its possible it is also soluble in naphtha.. Otherwise one can go with a more polar solvent like limonene/xylene.

I would go low on the base, though, im not sure of 5-meo-dmt's stability under highly basic conditions. Maybe sodium carbonate as a base or not going too much over ph 11 if using lye, just to be sure

maybe someone else has more info on this all?

also another option would be simple alcohol extraction on virola resin, but im not sure what form 5-meo-dmt is naturally and whether that is soluble in alcohol or not

just remember to start with very low doses, 5-meo-dmt can be quite disphoric and its potent at much lower doses than dmt
 
Well, it's the xlogp that influences solubility, not pH. Though that's also really similar. Might even freeze-precip from naptha, which'd be nice.

I think SWIM's going to be in the fuzzy dictatorship they call Singapore for a little while, so this is sort of idle speculation for at least the next few months.
 
lysergify said:
How about getting a pet Sonoran Desert Toad? Its venom is ~15% 5-Meo-DMT by weight, apparently you can smoke it as is. I haven't heard of possible extractions from that though.
Click to expand...

How about keeping a water-loving, stinking-of-toad-shit animal in your bedroom? not me. also, Its totally cruel. These toads are quite large (about the length of the forearm) they fight, they stink and they need a lot of room.
 
shoe said:
How about keeping a water-loving, stinking-of-toad-shit animal in your bedroom? not me. also, Its totally cruel. These toads are quite large (about the length of the forearm) they fight, they stink and they need a lot of room.
Click to expand...

Good point, I've never seen how they're kept in person but I agree that keeping animals of this sort (that are used to being wild) in captivity must be quite cruel.
 
endlessness said:
I would try a simple A/B on virola resin.

according to this: The pKa and XlogP values of DMT, 5-MeO-DMT, 5-HO-DMT, and related compounds - DMT Discussion - Welcome to the DMT-Nexus

xlogp of 5-meo is nearly the same as dmt, so its possible it is also soluble in naphtha.. Otherwise one can go with a more polar solvent like limonene/xylene.

I would go low on the base, though, im not sure of 5-meo-dmt's stability under highly basic conditions. Maybe sodium carbonate as a base or not going too much over ph 11 if using lye, just to be sure

maybe someone else has more info on this all?

also another option would be simple alcohol extraction on virola resin, but im not sure what form 5-meo-dmt is naturally and whether that is soluble in alcohol or not

just remember to start with very low doses, 5-meo-dmt can be quite disphoric and its potent at much lower doses than dmt
Click to expand...

Has anyone tried any of this?

Id really like to try 5-MeO-DMT from what i've heard about it - less visual/more feeling based, plus more related to enlightenment experiences rather than entity contact.
 
Virola peruviana did not work for SWIM. SWIM tried acid base, with low pH 4 and high pH of 12. Hexane, toluene, and xylene were all tried as non polar solvent. Long story short it didn't work although this plant is supposed to have alkaloids. Other virola species might be better.

Its most likely the high pH. Could be solvent but less likely SWIM thinks. Rumor is that 5meo is sensitive to high pH so watch out for that.
 
Although just to play devil's adovcate for a bit: SWIM found a source for these toads where you could buy them online.
I'd like to point out that they're ILLEGAL in the UK though and importing them and breeding them within the national boundary would, DUE ONLY TO THIS, be extremely profitable. *COUGH* WHAT!?!
 
SWIM has done a lot of 5-MeO and would definitely suggest trying it out, especially using the meditation tek you've spoken of before.
 
SpasticSpaz said:
Well, it's the xlogp that influences solubility, not pH. Though that's also really similar. Might even freeze-precip from naptha, which'd be nice.

I think SWIM's going to be in the fuzzy dictatorship they call Singapore for a little while, so this is sort of idle speculation for at least the next few months.
Click to expand...


Actually it's not really that simple. xlogp is a calculated logP. LogP actually isn't that great for charged molecules...logD would be better.

Even still there is more to it than that. There is thermodynamic solubility and kinetic solubility. Crystal packing can also play a huge role. Sometimes once you form crystals you form very stable dimers/trimers or higher order aggregates that are very hard to get back into solvent. Any chemist can tell you about compounds that have been recrystallized from water and were not soluble in water again with out extreme heat and agitation.

5-Meo-DMT should be very stable and will be slightly more water soluble than DMT because the oMe from the 5 position can form hydrogen bonds with water...also the 5 position is to far for the Basic nitrogen to bite back on itself... Psilocin however has huge problems because it forms an interna hydrogen bond between the free OH at the 4 position and the basic nitogren....which greatly facilitates oxidation.

The methoxy also protect it from oxidation much more so than a free OH like psilocin.

Just random food for thought.

Cheer
 
Hi guys , just wondering if anyone has looked into using Desmodium pulchellum as a source of extracting 5meo ? You can check out trouts notes on the desmodium genus . Whole plant contains dmt, 5meo, maoi inhibitors and other alkaloids, I have been preparing different parts of this shrub to test ... Really want to try an A/B extracting on mature stem and leaf for 5meo ... Was thinking about using sodium carbonate instead of hydroxide , and using exylene instead of napthpa .. Any thoughts on this ? What would be the recommended ph levels for base ? Trout states the following ...

“The alkaloids are readily extractable with alcohol containing acetic acid "


Mature stem and leaf (1.4% Total alkaloid) 5-Methoxy-DMT 34% 0.476%


Any feedback would be great ..thanks :)
 

Attachments

  • image.jpg
    image.jpg
    33.5 KB · Views: 0
  • image.jpg
    image.jpg
    46.4 KB · Views: 0
Go for it and let us know!

I´d have to look into it again, but make sure there aren´t poisonous alkaloids in this species!

Before bioassaying, post here :) Also I suggest getting some ehrlich and/or marquis reagents to try helping out identifying the alkaloids in it. Or if you´re waiting a couple more months talk to me again regarding TLC kits for more proper identification method.

Be well!
 
Back
Top Bottom