Food safe non polar liquid with high bioavailability?

[steppa]

Dear Nexus,

what would be be your choice for a food safe, non polar liquid with high bioavailability for use a base liquid for a sublingual tincture?

Backround is, that I'd like to make a fast acting, super strong canabis tincture by dissolving as much Honey Oil as possible in the yet to be found liquid.

I know that canabis tinctures are usually based on alcohol. But I don't really like the burn under the tounge. Any thoughts on this would be appreciated!

 

[hummus]

I don't know of anybody trying DMSO but it could be something to look into.
Or it depends how fussy you are, you can use just about any flavourless cooking oil like almond oil. I use coconut oil for all my edibles purposes and it makes very nice chocolates, but can also be mixed with some milk or another emulsifier and used in tea. It works as a massage oil too ..

 

[Parshvik Chintan]

why not just take honey oil sublingually?
why the need to make it into a tincture?

 

[endlessness]

I`ve tried a few times dissolved in olive oil and it worked great. My friend dissolved it so that 3 drops was mild, 6 drops was a strong experience. I heard coconut oil works good too.

 

[Entheogenerator]

Coconut oil is easily absorbed by the skin, I imagine the same would be true of the skin under the tongue. I know it is sometimes used to aid with the absorption of vitamins, so it might have the same effect with THC.

EDIT: Your best bet would probably be to use fractionated coconut oil, as it does not solidify at room temp like regular coconut oil does.

 

[steppa]

EDIT: Your best bet would probably be to use fractionated coconut oil, as it does not solidify at room temp like regular coconut oil does.

I`ll give that a try. Just ordered 100ml. Thanks!

My wife works at a pharmacie and she told me, that some commercial liquid drugs, which are applied sublingually are made with propylene glycol. But I`m not sure if this will dissolve the bho. I tried glycerin which didn`t work very well.

why not just take honey oil sublingually?

From my experience pure bho or weed doesn`t have much of an effect.

 

[Entheogenerator]

EDIT: Your best bet would probably be to use fractionated coconut oil, as it does not solidify at room temp like regular coconut oil does.

I`ll give that a try. Just ordered 100ml. Thanks!

My wife works at a pharmacie and she told me, that some commercial liquid drugs, which are applied sublingually are made with propylene glycol. But I`m not sure if this will dissolve the bho. I tried glycerin which didn`t work very well.

why not just take honey oil sublingually?

From my experience pure bho or weed doesn`t have much of an effect.

I have heard of people using PG to use BHO in an e-cig, but I'm not sure how effective it was. That might be a good way to go if the coconut oil doesn't work.

 

[benzyme]

I don't know of anybody trying DMSO but it could be something to look into.

dmso is actually somewhat common (and more effective than anything mentioned, due to its ability to permeate phospholipid bilayers), but it is quite polar and it stings.

 

[hummus]

Would you think it's able to dissolve cannabis terpenes?
And I can certainly confirm as a massage oil that coconut oil does transport the actives across the skin

 

[benzyme]

dmso dissolves most compounds and transports them, including toxins.
I use dmso as a transdermal application or tincture, I use palmitic, lauric, and linoleic/linolenic acids for other things.

 

[endlessness]

If you`re not getting effects, it`s not due to what its dissolved in, but rather the fact that your cannabinoids havent been decarboxylated. You need to heat it up...

 

[steppa]

the fact that your cannabinoids havent been decarboxylated

Yeah, the decarboxylation issue came to my mind a few minutes after posting my last post.

Well, the BHO I have right know should be fully decarboxylated. I guess I could test this, when I heat it to about 120°C and no small bubbles arise, right?

But then on the on the other hand one reads things like

Much of the THC in raw consumption is likely passed through the digestive system without ever being properly absorbed, because it lacks the lipids it needs to cross through otherwise impermeable membranes.

And I'm pretty sure that this is true, at least for consuming THC oraly. What I'm not sure about is if this is also true for sublingual application. Could someone elaborate on this please?

 

[endlessness]

But then on the on the other hand one reads things like

Much of the THC in raw consumption is likely passed through the digestive system without ever being properly absorbed, because it lacks the lipids it needs to cross through otherwise impermeable membranes.

And I'm pretty sure that this is true, at least for consuming THC oraly. What I'm not sure about is if this is also true for sublingual application. Could someone elaborate on this please?

That is only true for decarboxylated THC, thats why they said `raw form`. Once its decarboxylated, it will be absorbed and by itself will be lipid soluble, you dont necessarily need another oil/fat. It could be dissolved in just alcohol for example and still make you equally high.

 

[steppa]

thats why they said `raw form`.

They say THC-A when they talk about not decarboxilated THC. Here is another one

Raw cannabis if cured properly, will have most of the THCA converted to THC but lacks the lipids necessary to increase the amount of THC absorption during digestion.

In the first part they state that full dacarbocilation takes place even at room temp if the product has enogh time to decarboxilate. Regardless of this is true or not, the second part collides with what you are saying:

Once its decarboxylated, it will be absorbed and by itself will be lipid soluble, you dont necessarily need another oil/fat.

But again, I don't know if there is a diffence in biovailability if ∆-9-THC is applicated through the digestive system or via sublingual application. And I don't even know if this "lipids necessary" thing is true, as I have two contradicting statements right know.

Right know I'm reading a bit about DMSO, which sounds at least interesting. Thanks for pointing me in that direction.

 

[Dr_Sister]

If you want fast, Sister would recommend using DMSO. Dimethylsulfoxide. Sounds nasty but isn't and is available in food grade. It is a non polar aprotic solvent, whose speciality is transdermal absorption.

It used a lot by vets, but you can find it easily on amazon or ebay, not watched

 

[Parshvik Chintan]

yea, i have taken decarboxylated hash sublingually, and i assure you it is active undissolved

 

[steppa]

Sounds nasty

Indeed. I`ve read a few older threads here regarding sublingual DMSO and yeah...what I read sounded nasty. But anyways, I have 50ml DMSO right here now. I guess I`ll give it a try. But first...

yea, i have taken decarboxylated hash sublingually, and i assure you it is active undissolved

I`ll try this. Now. How much should I take for moderat effects? I guess my tolerance isn`t the lowest.

 

[Parshvik Chintan]

How much should I take for moderat effects? I guess my tolerance isn`t the lowest.

no clue, i never bother with measurements.
you won't overdose, i promise :lol:

 

[steppa]

Hihi. So...I just went with 0.1g. Recently I made capsules with bho and walnut oil. 0.08 in a capsule made me pretty red eyed. A friend testet two of those capsules with 0.1 each. She was floored for 36 hours and had to puke once. I'd call that an overdose.

Anyways...0.1 beeing held in the mouth for about 7 minutes or so give me effects. Considering that I would have been ridiculously stoned if I had vaped this on the Ti pad I think it's not worth it.
But on the other hand that was only 45 minutes ago. I'll wait to see if more happens.

 

[steppa]

Still getting stronger.