I just posted this in another thread where people were discussing citrate salts/DMT. I t doesn’t give clarity to the OP, but I hope he finds solace in the fact that I don’t have the problem outdoors, only in my own house.
Hi, newbie on here, long-time psychonaut (I’ll be claiming a pension some time soon) recent convert to vaping spice.
I’m looking for someone who has a grasp of H1 and H2 receptors involved in histamine responses, and whether these could somehow be triggered or sensitised by DMT.
I have used DMT (vaped) for a while as an ‘instant anxiolytic’ at low doses, and a super-relaxing, mild trip at slightly higher doses. I don’t use it for breakthrough, although I would like to try. (I’m an experienced tripper, favouring tryptamines over phenethylamines and feel that I am missing out on the full experience).
I had no problems with plain, nicotine-free, unflavoured vape juice, and always found that a bath in warm water solved any problems of dissolution (bath for the juice, not me). However, I once ran out of plain juice (I was away for a weekend) and used some flavoured nicotine for sub-ohm vapes. My first draw was fine initially, I felt the spice begin… then I was overcome by itching so intense and all-encompassing, I almost panicked. I recognised a histamine reaction, although I’d never had one before. My assumption (once I could think straight) was that DMT had dislodged any H1 antagonists (antihistamines), and the free receptors had then responded to the synthetic components of the vape juice, or the nicotine. This, I guessed, was what had caused the immediate urticaria. It was truly horrible, the only positive aspect being that it lasted only as long as the DMT. I got in the shower to remove any external histamine triggers like pollen or dust, although I guess that any positive effect gained was purely placebo due to the soothing and distracting effect of water pummelling my skin, and as a result of time passing.
My knowledge of pharmacology is limited; although I spent ten years as a qualified psych nurse, this was not something we encountered in our day-to-day work.
Can anyone explain (or make an educated guess) as to what mechanism might have produced this very strong effect, please? I have since found it difficult to use DMT indoors, even though I always use good quality spice (my own extract) and plain 70/30 e-juice. Once outdoors, it is a different matter. I have never experienced this in fresh air. I have even found that hotel rooms pose no problem (likely because they are cleaned so regularly).
This leads me to consider that the levels of dust and cat dander in our house were somehow involved. I simply cannot work out how it might have happened. Unfortunately, I have very messy housemates and cannot depend on them to keep the place clean. I am unable to do it all myself as I have a chronic pain condition.
Irrespective of your (and my) opinions of those I live with, I am really just super-curious as to how this thing happened. It has happened again since, indoors, but as a result of an unexpectedly strong dose of spice that hadn’t been thoroughly dissolved by the person who made up the juice.
Any ideas, however outlandish, are appreciated. If this should be posted in a different forum, please let me know and I will change it.
Thanks very much in advance.
Lily
Hi, newbie on here, long-time psychonaut (I’ll be claiming a pension some time soon) recent convert to vaping spice.
I’m looking for someone who has a grasp of H1 and H2 receptors involved in histamine responses, and whether these could somehow be triggered or sensitised by DMT.
I have used DMT (vaped) for a while as an ‘instant anxiolytic’ at low doses, and a super-relaxing, mild trip at slightly higher doses. I don’t use it for breakthrough, although I would like to try. (I’m an experienced tripper, favouring tryptamines over phenethylamines and feel that I am missing out on the full experience).
I had no problems with plain, nicotine-free, unflavoured vape juice, and always found that a bath in warm water solved any problems of dissolution (bath for the juice, not me). However, I once ran out of plain juice (I was away for a weekend) and used some flavoured nicotine for sub-ohm vapes. My first draw was fine initially, I felt the spice begin… then I was overcome by itching so intense and all-encompassing, I almost panicked. I recognised a histamine reaction, although I’d never had one before. My assumption (once I could think straight) was that DMT had dislodged any H1 antagonists (antihistamines), and the free receptors had then responded to the synthetic components of the vape juice, or the nicotine. This, I guessed, was what had caused the immediate urticaria. It was truly horrible, the only positive aspect being that it lasted only as long as the DMT. I got in the shower to remove any external histamine triggers like pollen or dust, although I guess that any positive effect gained was purely placebo due to the soothing and distracting effect of water pummelling my skin, and as a result of time passing.
My knowledge of pharmacology is limited; although I spent ten years as a qualified psych nurse, this was not something we encountered in our day-to-day work.
Can anyone explain (or make an educated guess) as to what mechanism might have produced this very strong effect, please? I have since found it difficult to use DMT indoors, even though I always use good quality spice (my own extract) and plain 70/30 e-juice. Once outdoors, it is a different matter. I have never experienced this in fresh air. I have even found that hotel rooms pose no problem (likely because they are cleaned so regularly).
This leads me to consider that the levels of dust and cat dander in our house were somehow involved. I simply cannot work out how it might have happened. Unfortunately, I have very messy housemates and cannot depend on them to keep the place clean. I am unable to do it all myself as I have a chronic pain condition.
Irrespective of your (and my) opinions of those I live with, I am really just super-curious as to how this thing happened. It has happened again since, indoors, but as a result of an unexpectedly strong dose of spice that hadn’t been thoroughly dissolved by the person who made up the juice.
Any ideas, however outlandish, are appreciated. If this should be posted in a different forum, please let me know and I will change it.
Thanks very much in advance.
Lily
