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Research Haphazard Intranasal Administration

Research done by (or for) the DMT-Nexus community

stuartroelke

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As the resident salvia explorer, my civic duty was to finally attempt intranasal administration of S. divinorum leaf powder. What a delight.

Snorting was not the least bit uncomfortable—no stinging, burning, or foul post-nasal drip. I was honestly shocked by how pleasant it was, and immediately became tempted to replicate in the other nostril. For the sake of the test I decided not to.

From what I had read, the expected onset would be ~5 minutes. My personal experience was that it didn't peak until ~15 minutes, the strongest effects were felt for ~20 minutes, and it gradually tapered off during an additional ~20 minutes. It's a rough estimate because I chose not to monitor time during this first go. Not as long as Salvine Tek, but a decent increase in duration compared to smoking.

The intensity was perfect for meditation, and was comparable to inhaling a bowl of plain leaf or quidding 5-6 leaves. Bumping in both nostrils might have sent me further than I initially wanted to go. Attached is an image of my attempted recreation, though it's not possible to know what the weight was. Next time I will try to measure.

It was a mistake not to rinse my sinuses before bed. There must have been just enough salvinorin A in my nasal cavity (5-6 hours later) to impact resting brain chemistry. Reactivations kept me awake throughout the night. For me, this has been common when experimenting with Salvine Tek too close to bedtime. All dreams become like a salvia trip, and the intensity is enough to trigger immediate jolts out of slumber.

My biggest fear with rawdogging salvia powder is cleanliness. I grow my own plants outdoors during the summer, so I've got some control over harvesting and drying. I typically collect stalks after rainfall and never wash them. Therefore, I would prefer to eventually follow in the footsteps of folks who have attempted to make a clean nasal spray. It may even suffice to apply some sort of semi-sterilized extract to inert powder. Anything to reduce the possibility of a sinus infection without destroying valuable compounds.

Let's the games begin (yet again).
 

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Very interesting. Could a purified extract be adsorbed onto mannitol, by dissolving the extract in an organic solvent, mixing with the mannitol, and evaporating? That's the usual diluent for commercial mesembrine extracts, converting that sticky oil to a free-flowing powder that's commonly insufflated. Extreme care would of course be required to confirm uniform distribution, since a hot spot could result in a huge overdose.
 
Very interesting. Could a purified extract be adsorbed onto mannitol, by dissolving the extract in an organic solvent, mixing with the mannitol, and evaporating? That's the usual diluent for commercial mesembrine extracts, converting that sticky oil to a free-flowing powder that's commonly insufflated. Extreme care would of course be required to confirm uniform distribution, since a hot spot could result in a huge overdose.
I’m unfamiliar with intranasal in general, so thank you for the astute suggestion! Soaking in ethanol, distributing on mannitol, and re-blending in a clean coffee grinder might be the way to go. This process could potentially reduce risk of infection while providing more control over potency.

Spent salvia powder tends to be 1/2 to 2/3 of the total weight depending on technique, so 1/2 the weight in mannitol would be a good place to start.

I don't suppose a salt solution extract tincture would work? Stick it in a nasal spray bottle?
Would probably have to be filtered but maybe the salt would sanitise anything you are worried about snorting from your garden.
Salvinorin A is lipophilic, so it couldn’t be suspended in ordinary saline. Though, an atomized solution might reduce the need for a nasal rinse? If true, this would be a nice end goal. I still have to research common base ingredients for nasal sprays.
 
Soaking in ethanol, distributing on mannitol, and re-blending in a clean coffee grinder might be the way to go.
If the active ingredient adsorbs properly then you should get a visually uniform, free-flowing powder, so the coffee grinder shouldn't be necessary. If you don't, then I wouldn't trust the product even with subsequent mixing. The process should look similar to adsorption onto silica or Celite for dry loading onto a chromatography column, and you can find videos demonstrating that (though obviously don't insufflate those!).

I might try acetone before ethanol since it evaporates faster, though I have no experience with salvinorins. I would start with the purest extract possible, to minimize the amount of extra gunk that needs to adsorb. It would be nice to test uniformity before consuming, even if only by TLC. If not then I would start with an extremely low dose and work up.

I'm not aware of any non-irritating solvent for salvinorins. Here's a study where researchers administered Salvinorin A dissolved in a mixture of 25:75 DMSO : PEG-400 sublingually to human subjects, apparently without harm though also without any other effect. A different study administered intranasal Salvinorin A to mice, also using DMSO. I think I'd try the mannitol before messing with that though.

The human study used plant material purchased from Bouncing Bear Botanicals. It's too bad they moved into the K2/Spice--they went to prison, an unfortunate precedent was set for MHRB (which was mentioned initially though I think not in the final charges), and Harvard lost its supplier.
 
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