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Harmalas and Beta Blockers?

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Tyler_Trismegistus

Tyler_Trismegistus

Rising Star
Hey guys (and girls of course)

I was just wondering about the safety of harmala alkaloids combined with beta blockers. In particular metaprolol, which I know is a lot different with its action than pindolol. On Erowid, it says that MAOI's may make the effects more potent which would result in lower blood pressure. If you have normally high blood pressure, and regularly take the beta blockers, wouldn't this not be that much of a problem? If anyone here has any insight or even experience about taking beta blockers and doing ayahuasca or even harmalas on their own, I'd be really interested to hear :) Thanks!
 
Betablockers block the beta adrenergic receptors that adrenaline normally binds to (to intitiate fight or flight response for example), harmalas inhibit the breakdown of adrenaline therefore you could get an imbalance in the body whereby too much adrenaline is flooding the available receptors.
Im no medical expert and cant say for sure one way or the other but from what I understand about the processes involved, and considering it is messing with systems that affect the circulatory system then it seems to me this combination is not a good idea.
 
You'd think that irreversible maois would be more dangerous with this combo, however it seems white a few doctors petscribr nardil along with propanolol and their patients don't have any negative results.... hmmmm.
 
Metoprolol is an interesting beta blocker which does require some caution with MAOIs (as all drugs of the class do) as an increased hypotensive effect can result from combining the two; it does not represent an absolute contraindication. Moclobemide, the RIMA, can cause this but clinically the effect is usually mild. Metoprolol is very dependant on CYP2D6 for its metabolism and there does exist a range of genotypic expression of this subtype between individuals. Harmine and harmaline are competitive inhibitors (and also substrates) for this enzyme subtype so conceivably this could amplify the exaggerated hypotensive effect if taken with metoprolol.
 
I was hoping you'd show up here! Thank you for that. I don't take them every day.... moreso on an as needed basis. I'd imagine the risk should be pretty minimal if I wait 48 hours since the last time I took the metoprolol to take some pharma.
 
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