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History of DMT Extraction?

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Enigmatic Visons

Rising Star
Greetings,

I've had this question bouncing around in my head for quite some time and can't seem to find the answer I am looking. That question is:

When did DMT freebase first begin being extracted from natural sources to be smoked?

I understand that Nick Sand is widely considered the first person to smoke DMT back in the 60's. But I was under the impression that he was synthesizing DMT and not extracting. So if anyone could be so kind as to point me in the direction of some reading material or have some knowledge about the history of DMT extraction that they would like to share that would be great!

Much Luv!

- Enigmatic Visions
 
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Piece of history of DMT

I had somone message me about some things back in the day when the community was just getting big on the net. I came to realize that many people didnt know much about the old DMT culture which was DMT World. So I wrote this as a history of the community when I was a part of it back then. I...
forum.dmt-nexus.me forum.dmt-nexus.me

This will answer all your questions, for me personally it’s a place called DMTworld where I found the earliest versions of dmt extractions, I think it’s just before the millennium that I was getting into this hobby, it feels a lifetime ago, plus I was very young, a tantalizing time where lots of exciting experiments where done to make the things that are now called TEKS. Read up on the notes of Vovin and if you have any questions, let me know.
 
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Thanks a lot @Varallo and @brokedownpalace10 💛 I took a quick look and so many gems in there. I will definitely take the time to read it all.

I was looking at the first pages of the official extraction help thread and I was fascinated by how much things have changed and improved since then, so many mysteries solved, I'm so grateful for all the beautiful people on the nexus. and I got really curious to know how things were before and how it all started.

@Varallo, indeed Vovin's posts do have all the answers but then I got drawn into his other writings and remembered that I've been in that rabbit hole before :ROFLMAO: fascinating stuff!

@brokedownpalace10 super interesting link! can't wait to read more.
Extraction of Harmala Alkaloids
...For the Syrian Rue,
we first ground the seeds very fine [in a spice
mill]. The second extract was a bright cloudy
yellow which may indicate harmine in
solution.

The plant material was strained and
compressed after each extraction.
Click to expand...
funny that pressing the plant material to get the alkaloids out was mentioned so long ago and I then rediscovered how it makes rue extraction much easier with whole seeds many many years later.

@quantumtantra the question with ayahuasca is much harder to answer, for the indigenous cultures of the amazon it's probably been there for as long as they can trace their own history and origins, and probably contributed greatly in shaping their culture and traditions, so it's kind of been there even before them as a culture. Indeed, I am grateful to be living in a time where I can reliably and safely access the DMT experience in my home and on my own (thanks to the nexus of course).
 
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When first isolated from a plant source back in 1946, the compound was named "nigerìna", or nigerine, and was only subsequently discovered to be identical with N,N-DMT, which had first been synthesised in 1931.

J. Ott laid this out in his book, "Ayahuasca Analogues" (1994), albeit without any explicit directions for DMT extraction.
 
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Transform said:
When first isolated from a plant source back in 1946, the compound was named "nigerìna", or nigerine, and was only subsequently discovered to be identical with N,N-DMT, which had first been synthesised in 1931.

J. Ott laid this out in his book, "Ayahuasca Analogues" (1994), albeit without any explicit directions for DMT extraction.
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Do they mention why it was synthesised initially?
 
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Sakkadelic said:
Do they mention why it was synthesised initially?
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Nothing is explicitly mentioned about motivations in the book. The reference is:
Manske, R.H.F. 1931. "A synthesis of the methyl-tryptamines and some derivatives" Canadian Journal of Research 5: 592-600
which may or may not reveal more about the motivations, and yes - that's the same Manske as in Manske precipitation. He and his team had already reported synthesising harmaline in 1927. [J. Chem. Soc. (Org) 1927: 1-15.]

I've not yet had the chance to read these papers.
 
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Transform said:
Nothing is explicitly mentioned about motivations in the book. The reference is:
Manske, R.H.F. 1931. "A synthesis of the methyl-tryptamines and some derivatives" Canadian Journal of Research 5: 592-600
which may or may not reveal more about the motivations, and yes - that's the same Manske as in Manske precipitation. He and his team had already reported synthesising harmaline in 1927. [J. Chem. Soc. (Org) 1927: 1-15.]

I've not yet had the chance to read these papers.
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It does not seem to mention anything more then an interest, also I think that Stephen Szarza should be mentioned as he was the one who first published about the effects of dmt in man.
 

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Varallo said:
It does not seem to mention anything more then an interest, also I think that Stephen Szarza should be mentioned as he was the one who first published about the effects of dmt in man.
Click to expand...
It appears, from the preamble in the 1931 paper, that Manske's interest lay in the direction of more complex polycyclic alkaloids (viz, calycanthine) and that methylated tryptamines were intermediates in that synthetic pathway.

Phytochemical trivia tangent: calycanthine occurs in Calycanthus occidentalis alongside harmine, which highlights Manske's interests in this direction. (And iirc, chemically unrelated yet similarly convulsant poisons occur in Illicium anisatum, which is also a source of safrole.) The question arises - did Manske ever comment on the pharmacology of harmine? He was a hair's breadth from discovering pharmausca back then!

And yes, it definitely crossed my mind to mention Szara's experiments too. That laid some important foundations for subsequent psychedelic science.
 
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