Yes this matches my experience also, about an hour in for harmala brews before taking the DMT. And there's nothing stopping you from topping up by drinking a bit more harmalas after another hour and a half to two hours either.In total the effects of Harmalas last about 6 to 8 hours, up to about 10 hours with heavier dosages. The MAO-A inhibition in the gut however, is transient and only lasts up to about an hour and a half to two hours into the Harmalas, after that if you try taking DMT it won't be orally active. Ime the best time to take DMT (and some other things) is an hour into the Harmalas, however if you're ingesting some sort of material like Mimosa root powder capsules or mushroom powder capsules, 30 minutes into the Harmalas is ideal, ime, but if you're using DMT in pure form or in tea form or in encapsulated residue form, an hour into the Harmalas is best, an hour apart is also best ime for orally activating Tryptamine from Tryptophan, and for potentiating 4-ACO-DMT. So overall you have about 30 minutes to an hour to get the DMT in ya, any sooner or later than that and the DMT won't be active to full/maximum effect but can still work (though might be shorter in duration of less than 3 hours whereas DMT's full duration should be 4 to 5 hours when taken properly). So take the DMT an hour into the Harmalas/Rue/Caapi, give things another hour to fully kick in and hold on to your butt.
Maybe try using less rue, it could be blocking the DMT effects, assuming that your AC actually works.is there a reason why dmt is not getting active if someone is having 4g of syrian rue in capsules, and 30 min later 4g of AC in capsules? He gets the maoi effects, he says he feels very dizzy….
Any thoughts?
Maybe try using less rue, it could be blocking the DMT effects, assuming that your AC actually works.
Something about 5HT receptor site occupancy - the harmala alkaloids can "get in the way" of the DMT. This is something that Jonathon Ott mentioned in his book "Ayahuasca Analogues" back in about 1995. I'd have to dig around a bit for more details. Something tells me harmol might act in this way, based on my experiences with sea buckthorn bark extract.A bit on the side, but what about this that rue (harmalas) can block DMT effects? I've read this or something similar a very few times, but in my experience I'm suspicious of just this. Most times I just read that the more rue you take the more apparent is the rues own effects, but not that it diminish the DMT. Could you elaborate a bit more?
is there a reason why dmt is not getting active if someone is having 4g of syrian rue in capsules, and 30 min later 4g of AC in capsules? He gets the maoi effects, he says he feels very dizzy….
Any thoughts?
Something about 5HT receptor site occupancy - the harmala alkalids can "get in the way" of the DMT. This is something that Jonathon Ott mentioned in his book "Ayahuasca Analogues" back in about 1995. I'd have to dig around a bit for more details. Something tells me harmol might act in this way, based on my experiences with sea buckthorn bark extract.
Don't get me wrong, I prefer more harmalas too. It seemed worthy of mention that this viewpoint exists, but also that we should discuss its validity - it could be completely outdated, or it could be a matter of natural variation between different people. @Gussss still ought to establish whether the acacia material is even active, though!Ime, it's actually better to use heavier Harmala dosages, the stronger the Harmala dosage the more MAO-A is inhibited and the more bioavailable/fully orally active the DMT is, and the more the higher dosage Harmala effects come out, but the DMT as far as i could tell was never blocked, altered sure but not blocked, still worked like a charm, just the higher Harmala dosages made things more Aya-like whereas when using lighter/more moderate Harmala dosages the effect is more DMT-like. I do however think/feel like there's a particular dosage range of Harmalas that allows things to be a bit more visual but beyond that it's like the visual aspect goes away (for me anyways) and things become more physical. Other than that though i definitely prefer and recommend heavy Harmala territory, haven't found it to block the effects of DMT at all. Now perhaps if you have a lot of THH in the mix or something that increases Serotonin a good bit (aside from the MAO-A inhibition) maybe then the DMT's effects at Serotonin receptors could be reduced, but i haven't found mere MAO-A inhibition to get in the way at all. With that said though, there's a wide variety of ways that one can alter DMT (as well as Harmalas) by the addition of some admixture plant or something, and that i feel is worth investigating.
Ime waiting 30 mins is enough. Is waiting 60 mins leading to a deeper experience? I doubt about that. A shorter one I think.
For an all night long (dusk to dawn) maoi I start with 200 mg harmalaHCL then each 2 hours topping up with 100 mg. Take any tryptamines at will after 30mins of the 200 starter.
I keeps one below nausea level and not getting too harmala-tired/lazy so you can be active all the time.
Thanks for that Sabnock1990,Ime DMT can be orally active at different timings, however the maximum bioavailability/oral activation of DMT occurs an hour into the Harmalas when gut MAO-A inhibition reaches it's max. Whereas if i take DMT say 30 minutes after Harmalas, sure it's active, but it's not as strong and doesn't seem to last as long as when dosed an hour after the Harmalas, due to gut MAO-A not being fully inhibited around 30 minutes in. Same thing i've noticed with Tryptophan for Tryptamine activation, and for Psilocin potentiated for Psilohuasca, it seems an hour into the Harmalas is best since gut MAO-A is inhibited to the max. 30 minutes apart can still work though i reserve 30 minutes apart for if i'm taking like Mimosa or Acacia root powder encapsulated or mushroom powder encapsulated or eating mushrooms, but for Mimosa/Acacia teas, for mushroom tea, for 4-ACO-DMT, for Tryptophan/Tryptamine, an hour into the Harmalas is ime best.
Also no need to take more than one Harmala dose ime, just need like 180 to 200mgs of Harmalas, and an hour later take a good dose of the DMT or Psilocin and you're good to for a full nights journey. The DMT will last 4 to 5 hours in total duration, the Harmalas will last 6 to 8 to 10 hours in total duration depending on dosage, and potentiated Psilocin will last 9 to 12 hours in total.