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I want to up my pharmahuasca dosage

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Tubuloid

Rising Star
Last time I did pharma, I took 150mg of harmala alkaloids and 150mg of DMT and had the best psychedelic experience of my entire life. I want to go higher but I'm not sure how much higher I should go. The trip was incredible but throughout it I felt like I was just on the edge of something even more beautiful and blissful than the state I was in. Does anyone have experience with pharmahuasca doses above the 100-200mg DMT range? I was thinking maybe going up to 300mg of DMT with 200mg of harmalas. I'm an experienced psychedelic user and would have a tripsitter with me, plus I have a lot of experience with vaped freebase so I'm not super worried about things going sour, I'm just not really sure what to expect. There aren't a lot of high dose pharmahuasca trip reports around.
 
I predose by 30-40 minutes usually. Is that enough or should I wait longer? The harmala alkaloids I'm using are extracted from Rue if that makes any difference.
 
Tubuloid said:
I predose by 30-40 minutes usually. Is that enough or should I wait longer? The harmala alkaloids I'm using are extracted from Rue if that makes any difference.
So you're taking 2 doses harmalas and how much is each?
With predosing for example you take 100mg harmalas followed after an hour by a second dose of 200mg harmalas and your dose of dmt...
 
Tubuloid said:
I predose by 30-40 minutes usually. Is that enough or should I wait longer? The harmala alkaloids I'm using are extracted from Rue if that makes any difference.
If you mean that you ingest the harmalas and then after 30-40 minutes the dmt without accompanying harmalas, then likely a lot of the dmt is broken down by mao enzymes in the gut.

It is best to always take some harmalas together with the dmt. Preloading harmalas anywhere between 15-45 minutes may help, but I have personally not found it necessary at all.

Beware that a lot of the rumors about taking harmalas 30 minutes or more before ingesting dmt seems to stem from people ingesting capsules of (ground) rue seeds. In that case, the digestive system needs time to extract the alkaloids from the seeds. When using extracted and purified alkaloids, or even a plain tea, there should not be such a long delay.

Also consider that in the amazon jungle, the caapi and chacruna tea is ingested at once. No delay is employed between the two in the original ayahuasca tradition.
 
Tubuloid said:
Last time I did pharma, I took 150mg of harmala alkaloids and 150mg of DMT and had the best psychedelic experience of my entire life. I want to go higher but I'm not sure how much higher I should go. The trip was incredible but throughout it I felt like I was just on the edge of something even more beautiful and blissful than the state I was in. Does anyone have experience with pharmahuasca doses above the 100-200mg DMT range? I was thinking maybe going up to 300mg of DMT with 200mg of harmalas. I'm an experienced psychedelic user and would have a tripsitter with me, plus I have a lot of experience with vaped freebase so I'm not super worried about things going sour, I'm just not really sure what to expect. There aren't a lot of high dose pharmahuasca trip reports around.


Hey Tubuloid!

The dmt dosages you mention are very high and your harmalas kind of low ime. Ofcourse there is nothing wrong with this if it works for you and you prefer it. The trick with pharma is to get as close as you can get to full MAO inhibition. After that point, 150mg will become very powerful, the chance being very high that you could be overwhelmed by 200mg dmt. Try to up your RIMA dose and see how that goes.

My opinion is that when the action of monoamine enzymes is only partially paused, some of them still being active, a lot of the ingested dmt dose still gets broken down by these.. so more or less some of it goes to waste. This on the other hand should only happen to a minimum when inhibited corectly.
 
Go for at least 180mgs to 200mgs, preferably 200mgs of Harmalas in a capsule, and then anywhere from 30 minutes to an hour later take your DMT. I've never needed two separate doses of Harmalas, i take my Rue seed powder capsules, or my freebased Rue extract capsule, or my freebased purified Harmala (Harmine/Harmaline) extract capsule, and then 30 to 45 minutes to an hour later i take my Mimosa or Acacia residue capsules or tea, works like a charm.

Ime it is definitely better to separate the DMT and the Harmalas, take the Rue/Harmalas (or Moclobemide) first, wait for MAO-A to become fully inhibited in the gut, and then take the DMT/DMT-containing plant. Always works, no duds, as full on as it can be, you just have to try a few different time windows to see when gut MAO-A inhibition is at it's peak. If you take the DMT too soon or too late, MAO-A might not be inhibited fully enough and some or all DMT will be inactivated, so it's best to wait until gut MAO-A is fully inhibited and then take the DMT. Encapsulated Harmalas, i think, tend to inhibit gut MAO-A a bit longer than Harmalas in tea form, though i still need to experiment around more with Harmala-containing teas.

Remember, the more Harmalas/Rue/Caapi/Moclobemide you use, the less DMT you will need for full effects, a full on dose of Harmalas would make 150mgs of DMT really potent so adjust your Harmala dosage first, then when it's good, experiment around with the timing of when to take the DMT, and then experiment around with the DMT dosages. Also if you consume Harmalas regularly, the Harmala dosage can get stronger due to the reverse tolerance so as you go along you can reduce the Harmala dosage bit by bit for a relatively consistent Harmala dosage, but if you take it like once a week or less it shouldn't be an issue.
 
pitubo said:
Beware that a lot of the rumors about taking harmalas 30 minutes or more before ingesting dmt seems to stem from people ingesting capsules of (ground) rue seeds. In that case, the digestive system needs time to extract the alkaloids from the seeds. When using extracted and purified alkaloids, or even a plain tea, there should not be such a long delay.

Also consider that in the amazon jungle, the caapi and chacruna tea is ingested at once. No delay is employed between the two in the original ayahuasca tradition.

I understand about the Rue seed powder, but even the encapsulated extracts seem to hit about the same as the Rue seed powder, the Rue seed powder may be a bit delayed on occasion but the extracts are consistent. For me personally waiting 30 minutes to an hour to take the DMT has done me good. Also both Rue seed powder and extracts seem consistent in that when 2 full hours have passed, usually between an hour and a half to two hours, i consistently purge, so the alkaloids seem to be hitting me at the same timescale regardless if i'm using Rue seed powder capsules or encapsulated freebased Rue or Harmala extracts.

As for traditional Aya all in one teas, it is very common, apparently, for all in one teas to not work until after consuming it a few times, many people have wasted so much money on Aya that never worked for them, all they felt was the vine, it could simply be a Caapi dosage related thing (as in they personally needed more vine) but i'm pretty sure it has more to do with the DMT being metabolized out before MAO-A is able to be fully inhibited, hence why it's better to separate the two.
 
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