Ibogaine Analog Freebase to Fumarate Conversion

[Shizballs]

What's up guys? I've been a long term user of iboga alkaloids due to mental health issues and I gotta say, they really possess something unique despite their cardiovascular risks. Anyways, I've been following the development of a similar compound, tabernanthalog, which can induce the same neuroplasticity and benefits of ibogaine without the cardiovascular and perceptual complications (I understand this is a bit controversial, I definitely agree that the actual experiences possess a wealth of medical value).

Sorry if this got a bit long, but I managed to acquire a few grams of the stuff and as expected, I am seeing some benefit but I am depleting my stash quickly. I learned yesterday that I possess the freebase form of the substance. Due to scarce supply and understanding bioavailability and first-pass metabolism, I'd ideally like to convert this into either an HCl or Fumarate salt and possibly switch to IM administration. So I was wondering if I could simply use a modified FASA method to achieve this?

Here is a link to the structure of the molecule. It seems similar enough that fumarate can work, albeit probably less stable than DMT fumarate.

TL;DR can I use FASA on other tryptamines? What modifications might I need to make? Can I assume the same mol ratio? (I believe this is 2:1 for DMT?)

 

[RhythmSpring]

In the area of native usage the occasional death from iboga root powder doses is not unheard of. I'm pretty sure this is on the ethnopharmacological record. It would be nice to have a thread specifically discussing this aspect of the matter since this thread is targetted on the pure tabernanthalog compound.

I would personally get an EKG done before embarking on any deeper exploration of iboga in whatever form. Mind you, I am getting on a bit. Maybe a wrinkle and a grey hair or two.

I appreciate your kindness in asking me to start my own thread about this. I just felt the need to chime in since it seemed that the premise of the experiments was that of necessity--because there weren't any reasonably safe ways to get the benefits from iboga. I still believe the experiments are unnecessary, but I'll continue my perspective-sharing in another thread.

 

[downwardsfromzero]

You're very welcome - it raises an interesting point of discussion and between us all we should be able to find a lot of good data.

Maybe you know, I have a foot in both camps, having a firm grounding in chemistry alongside some powerful plant and nature spiritual/mystical experiences. Horses for courses, you might say. I tend not to say as much about the spiritual and mystical stuff because my trained vocabulary is on the other side of the fence.

 

[downwardsfromzero]

PS - considering this is technically a RC you ought to post some safety information to go with it. Them's the rules.

Of course. The pharmacological screening results are attached.

The effects of TBG (10 μM) on a wide range of targets was assessed by Eurofins Discovery. Assays were conducted in duplicate and the results were averaged. Targets with ≥50% inhibition are highlighted in blue. Exact n values for each experimental condition are reported in Supplementary Table 1. Specific statistical tests, information on reproducibility and exact P values are reported in Methods and in Supplementary Table 1.

Something that initially concerned me was inhibition of both the serotonin transporter and MAO-A. It is common knowledge on here that MAOI + SSRI is a potentially lethal combination, so I was extremely careful to start with very low doses below 5 mg and work my way up. I'm guessing that the actual MAO inhibition is much lower in vivo because I haven't experienced even minimal serotonin syndrome symptoms.

Thanks.

While you can't post in the actual RC or Nootropics sections yet, maybe (with a little luck) you'll be able to soon, so it seems pertinent to show you this message regarding such things: [NEW SUBFORA] 'Nootropics' and 'Novel Psychoactive Substances (RC)' - Announcements and Suggestions - Welcome to the DMT-Nexus

What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity )?

 

[Toshido]

This paper names 2 examples of rootbark-related deaths and 2 more of total alkaloids-related death and another that could be total alkaloid or rootbark (plus a bunch of pure ibogaine-related deaths). This is from 2012, there might be more cases since then if you search a bit.

Dang, reading through this scares me out of ever wanting to try Ibogaine as I'm a big drinker who is prehypertensive. A lot of deaths in that paper related to opiate use, cocaine use, methadone etc. But some we're just from myocarditis and myocardial infarction, proving that Ibogaine really raises your blood pressure. What a terrible way to go.

 

[Shizballs]

While you can't post in the actual RC or Nootropics sections yet, maybe (with a little luck) you'll be able to soon, so it seems pertinent to show you this message regarding such things: [NEW SUBFORA] 'Nootropics' and 'Novel Psychoactive Substances (RC)' - Announcements and Suggestions - Welcome to the DMT-Nexus

What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity )?

Thanks, I'll have a look.

What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity )?

I've used ibogaine VERY extensively through the years. It helps a lot with getting back to being productive when I am in a low point. It's hard to say atm but it does seem to have the same effect as ibogaine but it seems to be a little less potent. It's hard to give a definitive review right now due to other pharmacology interfering but I did seem to get a benefit.

Downsides are few aside from nonpsychoactivity. I did notice that any doses after the morning have interfered with sleep which was surprising. Other than that, very little to say. Gonna need to experiment more with a cleaner slate.