I do 5:1:1 herb, DMT, harmine. It depends a lot of what kind of leaf you are smoking, but using lavender or tobacco, 250mg is not a lot of leaf and delivers a 50mg DMT experience in a few hits if you so like. Making it stronger than that makes dosing tricky, especially if you're smoking it out of a regular tobacco wooden pipe. Even with this conservative ratio, I managed to put myself into white noise land with one hit by putting too much tobacco in the pipe.