benzyme said:I think it was Adam Gottlieb who proposed the dopamine supplementation; the
issue may be a couple things ..getting the right concentration that would not overload the enzymes,
and delivering the substrate into the intracellular membranes. it's also been speculated that a polar aprotic solvent
could do just that
I think this is right, particularly regarding the concentration of the dopamine solution, as dopamine is rather irritant/caustic.Its used in humans to support blood pressure and renal perfusion in patients whose BP is less than 80mmHg for whatever reason (cardiac failiure, septic shock etc) and must be administered via a central line ie a venous catheter inserted into the internal jugular vein.Infusing it via a smaller peripheral vein runs the risk of marked tissue necrosis should it extravaste into the peripheral tissues.
Icon, that IO device looks great- a definite improvement on the traditional intra-osseous needle. :twisted: