syberdelic
Rising Star
Is there any source at all that concludes DMT to be a 5-HT3 agonist? I haven't ever come across one, and many members have stated it is not a 5-HT3 receptor agonist, DMT doesn't affect that receptor.
As far as the Harmalas go, i'm not sure if it interacts with 5-HT3 either, but something tells me it might, and could perhaps be blocked with the right dosage of a 5-HT3 antagonist, like Zofran for example, but remember, Zofran is metabolized by CYP2D6 and CYP1A2 which are inhibited by the Harmalas, so a lower dosage would be needed. As an example, i take a medication called Tizanidine for sleep, which is metabolized by CYP1A2, and when i take a good dose of Rue/Harmalas, i have about up to 10 hours after consuming the Rue/Harmalas, that CYP1A2 remains inhibited, and thus my regular dose of 2 to 2 and a half tablets of Tizanidine, needs to be cut down into a half of a tablet for the same effects as 2 to 2 and a half tablets. CYP2D6 inhibition by the Harmalas, i think, is of similar potency, so anything being metabolized by that enzyme would also require a much lower dosage. So that's just something to keep in mind, it also applies to Caffeine which i've experienced being potentiated a lot when consumed with Rue/Harmalas, because it's metabolized by CYP1A2. Other than 5-HT3 for the Harmalas, i do think a good part of the Harmalas is cholinergic, which would cause some the motion sickness, and possibly some nausea or vomiting, i've always wondered about that. I wonder if people report any less nausea or vomiting when mixing Aya with an anti-cholinergic like Brugmansia, but either way, the Harmala reverse tolerance imo is still the best way to go to get rid of the nausea/vomiting and some other side-effects.
I know people can respond differently to the same compounds, but i'm telling you, it's definitely the Harmalas that are the main source of nausea and the source of the vomiting. The food poisoning, vertigo and motion sickness effect can be attributed to the Harmalas. Harmalas by themselves you may not notice much sickness unless you take a good dosage, but when DMT is added to the mix, more of the Harmalas effects are amplified and further more come to the surface.
The only thing about DMT that i've noticed that would contribute to nausea or vomiting, is it's intensity, and possibly some sort of cholinergic effect like motion sickness, which i've experienced with DMT-containing plants mixed with Moclobemide, DMT seems somewhat cholinergic, ime, though that could perhaps be some sort of interaction between DMT and the MAO-A inhibition and possibly not attributed to either one by itself, or it could've been attributed to my use of Cannabis during Aya/Pharma which also seems somewhat cholinergic or that it potentiates cholinergic effects, but that's the only thing about DMT i notice in terms of sickness. And it's intensity is mental, which being overwhelmed can definitely make you want to vomit, though voluntarily and not forcefully (as there's no stomach issues, it's just the intensity makes you want to vomit so it's psychological).
Once you do some good experimentation, i think your perspective on this will shift based on the understanding you gain by trying to figure out the source of the majority of nausea/vomiting, as i have. After awhile, it becomes quite clear that it's the Harmalas that are the purgatives, DMT may rush the purge along, but if you allow the stomach to become desensitized from the Harmalas by building up the reverse tolerance, you will see those side-effects go away.
As far as the Harmalas go, i'm not sure if it interacts with 5-HT3 either, but something tells me it might, and could perhaps be blocked with the right dosage of a 5-HT3 antagonist, like Zofran for example, but remember, Zofran is metabolized by CYP2D6 and CYP1A2 which are inhibited by the Harmalas, so a lower dosage would be needed. As an example, i take a medication called Tizanidine for sleep, which is metabolized by CYP1A2, and when i take a good dose of Rue/Harmalas, i have about up to 10 hours after consuming the Rue/Harmalas, that CYP1A2 remains inhibited, and thus my regular dose of 2 to 2 and a half tablets of Tizanidine, needs to be cut down into a half of a tablet for the same effects as 2 to 2 and a half tablets. CYP2D6 inhibition by the Harmalas, i think, is of similar potency, so anything being metabolized by that enzyme would also require a much lower dosage. So that's just something to keep in mind, it also applies to Caffeine which i've experienced being potentiated a lot when consumed with Rue/Harmalas, because it's metabolized by CYP1A2. Other than 5-HT3 for the Harmalas, i do think a good part of the Harmalas is cholinergic, which would cause some the motion sickness, and possibly some nausea or vomiting, i've always wondered about that. I wonder if people report any less nausea or vomiting when mixing Aya with an anti-cholinergic like Brugmansia, but either way, the Harmala reverse tolerance imo is still the best way to go to get rid of the nausea/vomiting and some other side-effects.
I know people can respond differently to the same compounds, but i'm telling you, it's definitely the Harmalas that are the main source of nausea and the source of the vomiting. The food poisoning, vertigo and motion sickness effect can be attributed to the Harmalas. Harmalas by themselves you may not notice much sickness unless you take a good dosage, but when DMT is added to the mix, more of the Harmalas effects are amplified and further more come to the surface.
The only thing about DMT that i've noticed that would contribute to nausea or vomiting, is it's intensity, and possibly some sort of cholinergic effect like motion sickness, which i've experienced with DMT-containing plants mixed with Moclobemide, DMT seems somewhat cholinergic, ime, though that could perhaps be some sort of interaction between DMT and the MAO-A inhibition and possibly not attributed to either one by itself, or it could've been attributed to my use of Cannabis during Aya/Pharma which also seems somewhat cholinergic or that it potentiates cholinergic effects, but that's the only thing about DMT i notice in terms of sickness. And it's intensity is mental, which being overwhelmed can definitely make you want to vomit, though voluntarily and not forcefully (as there's no stomach issues, it's just the intensity makes you want to vomit so it's psychological).
Once you do some good experimentation, i think your perspective on this will shift based on the understanding you gain by trying to figure out the source of the majority of nausea/vomiting, as i have. After awhile, it becomes quite clear that it's the Harmalas that are the purgatives, DMT may rush the purge along, but if you allow the stomach to become desensitized from the Harmalas by building up the reverse tolerance, you will see those side-effects go away.