Ha, I mistakenly assumed this would be a thread about actual space travel and psychedelics...
There was an online rumour (which turned out to be false) that NASA was researching cannabis for extended space travel.
I thought it was a good idea, I mean if your going to be stuck in a small space for an extended period of time, which also involves long periods of being unable to move, I could see cannabis consumption as being an aide to sanity...
It's sad that it was false, I think nasa could benefit from psychoactives in many ways, it's definantly a piece of the tool kit of humanity which NASA has, as far as I know, ignored.
As far as drug combinations, I feel they can be amazing (if done safely and responsibly), I also feel there should be some intention behind the combination, for example: 2-methyl-N,N-Dimethyletryptamine appears to be a tactile enhancing agent, but also appears to be fairly inactive otherwise*, so, perhaps this compound could be combined with something like 5,6-methylenedioxy-2-aminoindane or 3,4-methylenedioxy-pyrovalerone, in an attempt to enhance the tactile stimulation of these compounds (which have entactogenic properties, but still seem to fall short from the archetypal entactogens such as 3,4-methylenedioxy-N-methyl-amphetamine)
*
(with 90 mg, orally) "The entire body was becoming activated (in a good way) but not much going on in the head. I am mentally clear but with the entire touch system a bit more activated than I would choose. This peaked at 3 hours, and was gone in another 3 hours. Everything is tactile."
Again, education is key, it's important to understand pharmacology, drug interactions, and any potential risks involved. I think intention is important as well.
I think 2,5-dimethoxy-4-methyl-phenethylamine may serve well as a potentiating agent for various psychedelic compounds. shulgin called the compound a "pharmacological tofu" in that it enhances other psychedelic compounds, without adding much of its own "flavor" to the experience...
As far as dissociative anesthetics, such as 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone (ketamine) or 1-(1-phenylcyclohexyl)piperidine (PCP), it's harder for me to speak about these compounds as I have very little experience with them, and only have interest in them from a research standpoint (I have no interest in actually consuming these compounds).
-eg