Where do I see this reply you made. Im interested in the subQ option and timing - could be a great base to vape off of as I can vape inside the space on my pen also and having a subQ base would possibly really make it that much faster to vape up past my liminal state which is no fun and get towards breakout and then re-break over and over with vape if the subQ is helping hold it all up
I’m afraid my original reply is forever lost in the cosmos of automatically banned replies


♂
I'm somewhat fatigued, so forgive my rambles, but I do have some time and will try to do my best to summarize the parts I remember… You probably know most of what I will say if you are a surgeon (or even halfway interested in surgery, like your name suggests), but I'll try to include these extra bits to help all who read this safely understand what I'm saying.
I think my reply started with mentioning that I wanted to double check if your IMs were actually IMs or if you, like myself, would sometimes use the terms interchangeably to avoid having to dive into the finer details.
So my first DMT injection was with an insulin syringe (i think 26g and 10mm long) in the vastus lateralis. I thought this was IM, but later learned that it was most likely subQ depending on the actual length of the insulin needle and the thickness of my subQ (fat/adipose) layer. A typical IM there would need a 1” needle for someone with my weight and BMI.
Then I purchased the autoject II pen when I learned that a slight twist of the syringe could increase the sting due to tearing of the inner skin/muscle. Here I had to buy certain brand needles to fit the pen and the longest ones I could find were BDs (30g, so minimal sting, and 1/2” long)
From here, I could easily do deltoid which is very likely to just barely be IM with my body. Left deltoid with 0.88-1.1mg/kg is great for 3-5 minute onset, 40m duration, and a gentle breakthrough.
If I go glutes, I can manage 1.0-1.3mg/kg for a 5-7m onset and 40-45m duration.
Most IM needles are going to be a lower gauge, so they sting more. The subQ, I think, is a great way to have a similar (if not better) experience and the sting is usually minimal. The worst stinging that can happen randomly (I assume from hitting small nerve endings) is always over before the DMT effects happen. This was not the case before the autoject II when accidental twisting would occur. It was this longer 10m sting (still a mild sting, but lingering) that could distract me from the experience.
When I was younger and dumber, I tried testosterone IM injections (gluteus, Maximus , with a much larger needle) and this is not something I would want to have to do to experience DMT.
I have never thought about vaping DMT on top of subQ, but it’s an interesting idea. I’m sure if it’s done right it could prolong the experience in more gentle waves, but the subQ would be 0.53mg/kg or so, as a 0.88-1.1mg/kg would nullify any ability to manage a vape pen after the 5-6m mark.
I don’t think DMT gets degraded significantly by fatty subQ layers. There is MAO there, but it should be overwhelmed and then the DMT will diffuse into the blood. The DMT should be in all pharmacokinetic compartments within these first five or so minutes, and from my experience, it doesn’t seem like there’s much degradation. I suspect even an IV bolus or infusion will transport the DMT to the fat within 5-10 minutes. Plus, I’m unsure if there’s more MAO in the adipose tissue of the subQ or in the brain…
You bring up good points. We need more research. Or maybe I/we need to start searching for the right papers!
0.3mg/kg of vaped harmalas can make me feel elevated. Maybe a little drowsy but not much. It is nothing like the body load from eating it, though I am currently experimenting with doses in the 0.08-0.23mg/kg range with the goal to find the dose that results in no noticable changes (until the DMT is administered).
I will soon try 0.152mg/kg vaped and then 0.46mg/kg subQ.
Glad you are alive and looking forward towards recovery! I too have lost interest with those oral forms of less efficacious entheogens and blends. 4-aco-DMT or purified psilocybin are still on the table for me. The oral ROA does have benefits related to social events, etc. Low dose pharmayahuasca might be something I'd do at a psychedelic wedding or other social gathering, but nothing large enough to be anywhere near nausea and purging.
Lastly, with your self proclaimed interest in surgery (by means of a username) I might have also mentioned my intentions to recieve a Port-a-Cath surgery one day. I feel called upon (by what I call, The Universal Creator) to get this surgery and to do DMTx breakthroughs every 1-3 months (many of them while alone, as this is where I have the best conversations with The Creator). I also feel called to microdose the DMT once a week or so while I sleep. Something so small that it doesnt wake me up. I suspect that I will live a better and longer life this way and am currently navigating the complex legal aspects of getting a surgery for religious purposes. I have a lawyer and a local PCP on board but she isnt quite sure who or how to refer me to the interventional radiologists (who are typically the cheapest route for the surgery), nor is she sure who to refer me to for regular heparin presecriptions etc, because all of this is out of her standard "wheelhouse".
Cheers,
Tripp