Making a harmala vape

[somanaut]

I'd like to make a vape with some harmala extract I have, but I could use some help deciding how to dose it.

Image attached is a batch of harmala extract I have, but I don't know the source or how it was extracted. From my sampling it seems like a full spectrum blend, ~35mg orally is a solid dose. I'm not sure if it's freebase or HCl.

I have PG carrier (DBmixPro), and my vape battery has a voltage range from 1.8 to 4.2v. Any idea what a smart ratio might be for my first cartridge?

 

[_Trip_]

Research Post in thread 'DMT salts for e-juice'

Feb 13, 2024

Just did some quick prompting :

Q: Can you first dissolve the DMT-freebase into PG and then add the appropriate amount of lactic acid?

A: Yes, you can first dissolve DMT freebase into propylene glycol (PG) and then add the appropriate amount of lactic acid to convert the DMT into its lactate form. This process involves several steps:

1. Dissolving DMT Freebase in PG: DMT freebase is not very soluble in water but is soluble in organic solvents, including propylene glycol. You would start by dissolving the DMT freebase in PG at a moderate temperature to help increase its...

• _Trip_

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There's some good info on harmala salts and solubility in this thread.
Iirc if your mixing dmt and harmala lactate salts where compatible. Otherwise there was trouble mixing both with differing slat forms. Lactate would make a decently safe salt. But a couple members who tested it weren't impressed with the taste so flavoured PG might be needed.

If harmala I'd all ypur after the thread might give you some ideas. Iirc from my tests Harmala lactate was the most stable and soluble form in Vape juice but more testing was needed and other salts can work.

 

[TransistorBass]

Someone can correct me if I'm wrong but I don't think anyone has yet successfully made Harmala Vape Juice.

My thoughts go to Ultrasonic Vapes but I have no experience or know anyone that uses one.

 

[Sakkadelic]

Image attached is a batch of harmala extract I have, but I don't know the source or how it was extracted. From my sampling it seems like a full spectrum blend, ~35mg orally is a solid dose. I'm not sure if it's freebase or HCl.

These harmala extracts often don't work or at best are weak. Unless you meant 350 mg, 35 mg of that extract being a solid dose would mean this extract is 5-6 times stronger than pure alkaloids, a solid dose is around 200 mg harmala alkaloids.

What about the taste of the powder, do you have experience with whole seeds to compare to? It's a good starting point to know if this is for real a peganum harmala extract.

Your best bet is to extract the extract and use purified alkaloids for your vape. The harmalas are likely in their salt form, and if the material is powdered and already processed, it should be easy to extract, and a a single pull of harmala CWE would suffice. For a 100g, soak in 2L of water with 50 ml distilled vinegar for a full day with occasional mixing. Then leave the powder to settle for a few hours and pour off the liquid slowly into another container, the liquid will have the majority of the alkaloids. Filter and base with a sodium carbonate or lye solution without overusing the base, let settle and decant, do a few water washes before collecting the freebase.

 

[The Sofa Traveler]

Someone can correct me if I'm wrong but I don't think anyone has yet successfully made Harmala Vape Juice.

My thoughts go to Ultrasonic Vapes but I have no experience or know anyone that uses one.

Yep, whether the salts used, harmalas solubility in e-cig bases/diols remains quite low. You can increase solubility by heating the e-cig base (pure PG for example) but harmalas crash out from solution once temperature drops back. You still could aerosolize low concentration harmalas juices but it loses its appeal when you have to aerosolize 1ml of e-cig base for a 30-50mg harmalas dose (which I think would be needed for a decent dose with this route). Better smoking or have sublingual route for one who wants a quick harmalas jump. Lately, for the fun, I tried to make 1,3-propanediol + harmalas cirtrate juice, I wasn't able to dissolve more than 50mg harmalas in 1ml base (which is more or less what I achieved with PG too). I think that to be comfortable and efficient, solubility should be at least 200mg/ml but I don't think someone achieved such concentration. Psychonauts still seeking efficient harmalas vape Holy Grail
I don't think ultrasonic vapes would help much either, it's just a coil-less way to heat the e-cig base for aerosolization but it will not help increase harmalas solubility in diols.

 

[_Trip_]

I had harmala lactate remain stable in a syringe without crashing out for over 12 months before I tossed it.

 

[somanaut]

Great discussion, thank you all! I think the first problem is identifying this mystery powder. It tastes similar to the seeds, but surprisingly not as bitter. It dissolves just fine in water.

So if it's not pure alkaloids, what did they do to extract it? Any ideas why it'd be labeled 10x?

Unless you meant 350 mg, 35 mg of that extract being a solid dose would mean this extract is 5-6 times stronger than pure alkaloids, a solid dose is around 200 mg harmala alkaloids.

You make a great point that the 35mg dose doesn't make sense! My harmala experience has always been with powdered seeds, but at a certain dose (~4g+) I'll end up purging for hours at a time. I'd be nervous to try 100mg of this powder, but maybe it's less purgative? I'll continue to titrate higher until I find the upper limit

Second problem will be playing with the solubility. It sounds like doing another extract and converting it to a lactate may have some luck.

My goal with the vape isn't necessarily a full MAOI dose, I'd just like to use it during ayahuasca to expand the harmalas.

 

[Sakkadelic]

So if it's not pure alkaloids, what did they do to extract it? Any ideas why it'd be labeled 10x?

Likely by using water or alcohol and then evaporating the liquid onto a 10th of the original seed mass. That would be the most simple and cheap commercial process. You'd have to account for the mass of the evaporated liquid which includes but is not limited to the harmala alkaloids, and the efficiency of the extraction. You could easily endup having less than 5x if the mass of the evaporated liquid equals to a 10th of the total mass. This just makes dosing with this stuff so unreliable.

Second problem will be playing with the solubility. It sounds like doing another extract and converting it to a lactate may have some luck.

I have no experience with vapes but I think you'd need a more purified product to improve your chances of success, so yes, starting with extraction. You'd be better off starting with seeds if you got them, it's also interesting to see what comes out of the so called 10x.

 

[yatyas314]

I just vaped the THH or harmaline or harmine freebase in its own atomizer on my Yocan Cylo.

 

[Transform]

You make a great point that the 35mg dose doesn't make sense!

It makes sense as an inhaled or sublingual dose, where the bioavailability is higher than via the oral route. But again, only if it was pure alkaloids.

My thoughts go to Ultrasonic Vapes but I have no experience or know anyone that uses one.

Thread 'Ultrasonic nebulizer: a new, important idea--must read!'

Jun 6, 2009

I have a new idea for delivery by lung of DMT--that would ALSO work for psilocybin, mescaline, or practically ANYTHING else (hopefully, anyhow). I want to use this thread for brainstorming about the idea. I especially hope our local chemists will chime in.

Here's what got me interested in this: I'm older, out of shape, etc., and I worry that it might be difficult for me to get breakthrough doses of vaporized DMT freebase. This is mostly because REAL DMT vapor seems to take a good 10 seconds of holding it in the lungs before exhale, to get the vapor to adhere to lung tissue. What...

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Post in thread 'Ultrasonic nebulizer: a new, important idea--must read!'

Sep 16, 2025

So, I finally give nebulizing DMT a try..

All and all a cool experiment, having "vaped" DMT-Fumerate.
And it's an interesting method using room temp droplets instead of heat.

Dissolved 771mg DMT-Fumerate in 2ml water and loaded it into the Omron A3.

The Omron has 3 mist drop size settings:
1: large drops at 0.7ml/min
2: medium drops at 0.5ml/min
3: small drops at 0.3ml/min

I used settings 3 because the manual said that the smallest drops penetrate deepest into the lungs. Inhaled for 10 seconds 3 times (30 sec total). Holding breath for 10 seconds after each inhalation...

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